Denervation of dopaminergic neurons with 6-hydroxydopamine increases nerve growth factor content in rat brain

Atsumi Nitta; Yoshiko Furukawa; Kyozo Hayashi; Masayuki Hiramatsu; Tsutomu Kameyama; Takaaki Hasegawa; Toshitaka Nabeshima

doi:10.1016/0304-3940(92)90738-S

Denervation of dopaminergic neurons with 6-hydroxydopamine increases nerve growth factor content in rat brain

Atsumi Nitta
, Yoshiko Furukawa
, Kyozo Hayashi
, Masayuki Hiramatsu
, Tsutomu Kameyama
, Takaaki Hasegawa
, Toshitaka Nabeshima

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

Denervation of dopaminergic neurons by intra nigral injection of 6-hydroxydopamine (6-OHDA) increased nerve growth factor (NGF) content in the cortex and hippocampus, both of which are innervated by cholinergic neurons. The increase continued during an observation period of 0.5-28 days after the lesion. The time course of changes in NGF content was quite different from that of cholinergic neuron denervation. The decreased dopamine content produced in the striatum by 6-OHDA injection was not recovered during the observation period. These results suggest that dopaminergic neuron damage may affect NGF synthesis.

Original language	English
Pages (from-to)	152-156
Number of pages	5
Journal	Neuroscience Letters
Volume	144
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(92)90738-S
Publication status	Published - 14-09-1992
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience

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10.1016/0304-3940(92)90738-S

Cite this

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title = "Denervation of dopaminergic neurons with 6-hydroxydopamine increases nerve growth factor content in rat brain",

abstract = "Denervation of dopaminergic neurons by intra nigral injection of 6-hydroxydopamine (6-OHDA) increased nerve growth factor (NGF) content in the cortex and hippocampus, both of which are innervated by cholinergic neurons. The increase continued during an observation period of 0.5-28 days after the lesion. The time course of changes in NGF content was quite different from that of cholinergic neuron denervation. The decreased dopamine content produced in the striatum by 6-OHDA injection was not recovered during the observation period. These results suggest that dopaminergic neuron damage may affect NGF synthesis.",

author = "Atsumi Nitta and Yoshiko Furukawa and Kyozo Hayashi and Masayuki Hiramatsu and Tsutomu Kameyama and Takaaki Hasegawa and Toshitaka Nabeshima",

note = "Funding Information: This study was supported, in part, by a grant from the Sandoz Foundation for Gerontological Research and by the Mrs. Kimi Tokuda Memorial Foundation.",

year = "1992",

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doi = "10.1016/0304-3940(92)90738-S",

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journal = "Neuroscience Letters",

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TY - JOUR

T1 - Denervation of dopaminergic neurons with 6-hydroxydopamine increases nerve growth factor content in rat brain

AU - Nitta, Atsumi

AU - Furukawa, Yoshiko

AU - Hayashi, Kyozo

AU - Hiramatsu, Masayuki

AU - Kameyama, Tsutomu

AU - Hasegawa, Takaaki

AU - Nabeshima, Toshitaka

N1 - Funding Information: This study was supported, in part, by a grant from the Sandoz Foundation for Gerontological Research and by the Mrs. Kimi Tokuda Memorial Foundation.

PY - 1992/9/14

Y1 - 1992/9/14

N2 - Denervation of dopaminergic neurons by intra nigral injection of 6-hydroxydopamine (6-OHDA) increased nerve growth factor (NGF) content in the cortex and hippocampus, both of which are innervated by cholinergic neurons. The increase continued during an observation period of 0.5-28 days after the lesion. The time course of changes in NGF content was quite different from that of cholinergic neuron denervation. The decreased dopamine content produced in the striatum by 6-OHDA injection was not recovered during the observation period. These results suggest that dopaminergic neuron damage may affect NGF synthesis.

AB - Denervation of dopaminergic neurons by intra nigral injection of 6-hydroxydopamine (6-OHDA) increased nerve growth factor (NGF) content in the cortex and hippocampus, both of which are innervated by cholinergic neurons. The increase continued during an observation period of 0.5-28 days after the lesion. The time course of changes in NGF content was quite different from that of cholinergic neuron denervation. The decreased dopamine content produced in the striatum by 6-OHDA injection was not recovered during the observation period. These results suggest that dopaminergic neuron damage may affect NGF synthesis.

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DO - 10.1016/0304-3940(92)90738-S

M3 - Article

C2 - 1436695

AN - SCOPUS:0026666242

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JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1-2

ER -

Denervation of dopaminergic neurons with 6-hydroxydopamine increases nerve growth factor content in rat brain

Abstract

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