TY - JOUR
T1 - Dengue fever during pregnancy
AU - Dat, Trinh Tien
AU - Kotani, Tomomi
AU - Yamamoto, Eiko
AU - Shibata, Kiyosumi
AU - Moriyama, Yoshinori
AU - Tsuda, Hiroyuki
AU - Yamashita, Mamoru
AU - Kajiyama, Hiroaki
AU - Minh, Dien Duc Thien
AU - Thanh, Le Quang
AU - Kikkawa, Fumitaka
N1 - Publisher Copyright:
© 2017, Nagoya University.
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Dengue fever during pregnancy is an expanding issue in Southeast Asia; however, the knowledge of adverse effects on mothers and neonates remains limited. Therefore, we aimed to determine the impact of dengue fever. The clinical information of 20 patients of dengue fever during pregnancy in Vietnam from January 1, 2015 to December 31, 2015 was collected and their outcomes were retrospectively investigated. A total of 18 patients (90%) presented with positivity of nonstructural protein 1, and a primary infection. Additionally, 4 patients (20%) had preterm deliveries and 1 (5%) had a stillborn child. All live-born neonates were discharged from the hospital uneventfully. Also, 6 patients (30%) required platelet transfusion and 3 of them received transfusion before delivery, but there were no maternal death. In addition, 3 cases of patients (15%) developed to postpartum hemorrhage (PPH), and their platelet concentrations were significantly lower than those of patients without PPH [90.0 (19.0 - 374.0) × 103 vs. 40.0 (12.0 - 57.0) × 103 cell/ml, p = 0.001]. In addition, patients with PPH also presented with elevated liver enzymes. Pregnant patients with low platelet counts should be recognized as being at high risk for PPH.
AB - Dengue fever during pregnancy is an expanding issue in Southeast Asia; however, the knowledge of adverse effects on mothers and neonates remains limited. Therefore, we aimed to determine the impact of dengue fever. The clinical information of 20 patients of dengue fever during pregnancy in Vietnam from January 1, 2015 to December 31, 2015 was collected and their outcomes were retrospectively investigated. A total of 18 patients (90%) presented with positivity of nonstructural protein 1, and a primary infection. Additionally, 4 patients (20%) had preterm deliveries and 1 (5%) had a stillborn child. All live-born neonates were discharged from the hospital uneventfully. Also, 6 patients (30%) required platelet transfusion and 3 of them received transfusion before delivery, but there were no maternal death. In addition, 3 cases of patients (15%) developed to postpartum hemorrhage (PPH), and their platelet concentrations were significantly lower than those of patients without PPH [90.0 (19.0 - 374.0) × 103 vs. 40.0 (12.0 - 57.0) × 103 cell/ml, p = 0.001]. In addition, patients with PPH also presented with elevated liver enzymes. Pregnant patients with low platelet counts should be recognized as being at high risk for PPH.
UR - http://www.scopus.com/inward/record.url?scp=85047493934&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85047493934&partnerID=8YFLogxK
U2 - 10.18999/nagjms.80.2.241
DO - 10.18999/nagjms.80.2.241
M3 - Article
C2 - 29915441
AN - SCOPUS:85047493934
SN - 0027-7622
VL - 80
SP - 241
EP - 247
JO - Nagoya journal of medical science
JF - Nagoya journal of medical science
IS - 2
ER -