Depression of afferent arc of the in vivo cytotoxic T-Cell immunity by bacterial lipopolysaccharides

Kenji Mizoguchi, Izumi Nakashima, Yoshinori Hasegawa, Ken ichi Isobe, Nobuo Kato, Kaoru Shimokata, Kohei Kawashima, Fumihiko Nagase, Ko ichi Ando, Tomoaki Yoshida, Hwa Lai

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Abstract

The afferent arc of the in vivo cytotoxic T-cell immunity assessed by second set rejection of ascitic allogeneic tumors was shown to be depressed by bacterial lipopolysaccharide (LPS) that was administered simultaneously with or 1 day before injection of allogeneic spleen cells as stimulators. Two different LPSs from Escherichia coli O55 and Klebsiella O3 displayed similar activities whereas dextran sulfate, concanavalin A, or poly A:U was not effective. Stimulator activities of allogeneic cells was not directly modified by LPS. Any definite suppressor activity on afferent or efferent arc of the T-cell response was not demonstrable in mice receiving LPS and allogeneic cells. Further, the LPS effect for immune depression was not diminished by whole body X-ray irradiation to the recipient at 300 R, which ablated the B-cell reactivity to LPS for polyclonal activation, or by treatment of the recipient with carrageenan, a known toxic agent to macrophages. It was suggested from these results that LPS suppresses the cytotoxic T-cell immunity by modulating responder T cells to be temporarily refractory to the allogeneic stimulus rather than by activating suppressor cells such as radiation-sensitive lymphocytes and carrageenan-sensitive macrophages.

Original languageEnglish
Pages (from-to)330-339
Number of pages10
JournalCellular Immunology
Volume95
Issue number2
DOIs
Publication statusPublished - 15-10-1985

All Science Journal Classification (ASJC) codes

  • Immunology

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    Mizoguchi, K., Nakashima, I., Hasegawa, Y., Isobe, K. I., Kato, N., Shimokata, K., Kawashima, K., Nagase, F., Ando, K. I., Yoshida, T., & Lai, H. (1985). Depression of afferent arc of the in vivo cytotoxic T-Cell immunity by bacterial lipopolysaccharides. Cellular Immunology, 95(2), 330-339. https://doi.org/10.1016/0008-8749(85)90320-X