Design optimization using GATE Monte Carlo simulations for a sub-0.5 mm resolution PET scanner with 3-layer DOI detectors

Objective.For rodent brain PET imaging, spatial resolution is the most important factor for identifying small brain structures. Previously, we developed a submillimeter resolution PET scanner with 1 mm crystal pitch using 3-layer depth-of-interaction (DOI) detectors. However, the spatial resolution was over 0.5 mm due to a relatively large crystal pitch and an unoptimized crystal layer design. Here we use Geant4 Application Tomographic Emission (GATE) Monte Carlo simulations to design and optimize a sub-0.5 mm resolution PET scanner with 3-layer DOI detectors.Methods.The proposed PET scanner has 2 rings, each of which has 16 DOI detectors, resulting in a 23.4 mm axial coverage. Each DOI detector has 3-layer lutetium yttrium orthosilicate crystal arrays with a 0.8 mm crystal pitch. We employed GATE Monte Carlo simulations to optimize three crystal layer designs, A (4 + 4 + 7 mm), B (3 + 4 + 4 mm), and C (3 + 3 + 5 mm). Spatial resolution and imaging performance were evaluated with a point source and resolution phantom using analytical and iterative algorithms.Main results.Among the three designs, design C provided the most uniform spatial resolution up to the radial offset of 15 mm. The 0.45 mm diameter rod structures were resolved clearly with design C using the iterative algorithm. The GATE simulation results agreed with the experimental data in terms of radial resolution except at the radial offset of 15 mm.Significance.We optimized the crystal layer design of the mouse brain PET scanner with GATE simulations, thereby achieving sub-0.5 mm resolution in the resolution phantom study.