TY - JOUR
T1 - Desmoplastic reactions and epithelial-mesenchymal transition proteins in stages II and III colorectal cancer
T2 - association with and prognostic value for disease-free survival
AU - Hashimoto, Mai
AU - Uesugi, Noriyuki
AU - Sugai, Mayu
AU - Ito, Kazuhiro
AU - Yanagawa, Naoki
AU - Otsuka, Koki
AU - Kajiwara, Yoshiki
AU - Ueno, Hideki
AU - Sasaki, Akira
AU - Sugai, Tamotsu
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2022/4
Y1 - 2022/4
N2 - Recent study has shown that there is a close association of desmoplastic reactions (DRs) with the survival of patient with colorectal cancer (CRC). Here, we examined the correlation of DR classification with disease-free survival and overall survival of CRC. Moreover, we also investigated the association of the histological transition of the DR with the expression of cancer-associated fibroblast (CAF)- and epithelial-mesenchymal transition (EMT)-related proteins in CRC in stages II and III. We examined 157 cases of stage II CRC and 163 cases in stage III. We classified DRs into mature, intermediate, and immature types and examined the correlation of the DR patterns with patient survival. Next, the expression of CAF- and EMT-related markers was examined in CRC samples using immunohistochemistry. In stage II CRC, we found a significant correlation of disease-free survival with DR subtype (immature vs mature) in univariate and multivariate analyses. In stage III CRC, however, such association was not identified. Finally, the DR was closely associated with two EMT-related markers in stages II and III CRC. Our findings suggest that classification of the DR may help to predict patient prognosis in CRC. Furthermore, classification of the DR is correlated with the expression of EMT-related proteins.
AB - Recent study has shown that there is a close association of desmoplastic reactions (DRs) with the survival of patient with colorectal cancer (CRC). Here, we examined the correlation of DR classification with disease-free survival and overall survival of CRC. Moreover, we also investigated the association of the histological transition of the DR with the expression of cancer-associated fibroblast (CAF)- and epithelial-mesenchymal transition (EMT)-related proteins in CRC in stages II and III. We examined 157 cases of stage II CRC and 163 cases in stage III. We classified DRs into mature, intermediate, and immature types and examined the correlation of the DR patterns with patient survival. Next, the expression of CAF- and EMT-related markers was examined in CRC samples using immunohistochemistry. In stage II CRC, we found a significant correlation of disease-free survival with DR subtype (immature vs mature) in univariate and multivariate analyses. In stage III CRC, however, such association was not identified. Finally, the DR was closely associated with two EMT-related markers in stages II and III CRC. Our findings suggest that classification of the DR may help to predict patient prognosis in CRC. Furthermore, classification of the DR is correlated with the expression of EMT-related proteins.
KW - Cancer-associated fibroblast
KW - Colorectal cancer
KW - Desmoplastic reaction
KW - Disease-free survival: Epithelial mesenchymal transition
UR - http://www.scopus.com/inward/record.url?scp=85124646242&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85124646242&partnerID=8YFLogxK
U2 - 10.1007/s00428-021-03266-4
DO - 10.1007/s00428-021-03266-4
M3 - Article
C2 - 35149891
AN - SCOPUS:85124646242
SN - 0945-6317
VL - 480
SP - 793
EP - 805
JO - Virchows Archiv
JF - Virchows Archiv
IS - 4
ER -
