Detection of a metallo-β-lactamase (IMP-1) by fluorescent probes having dansyl and thiol groups

Hiromasa Kurosaki; Hisami Yasuzawa; Yoshihiro Yamaguchi; Wanchun Jin; Yoshichika Arakawa; Masafumi Goto

doi:10.1039/b209086d

Detection of a metallo-β-lactamase (IMP-1) by fluorescent probes having dansyl and thiol groups

Hiromasa Kurosaki, Hisami Yasuzawa, Yoshihiro Yamaguchi, Wanchun Jin, Yoshichika Arakawa, Masafumi Goto

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

A fluorescent probe for the detection of a metallo-β-lactamase (IMP-1), N-[2-(5-dimethylaminonaphthalen-1-ylsulfonylamino)ethyl]-3-mercaptopropionamide (Dansyl-C2SH), 1, was designed based on combining the inhibitory function of mercaptocarboxylate and a fluorophore. The binding of 1 to IMP-1 was investigated by fluorescence spectroscopy. Compound 1 can act as fluorescent probe for detecting IMP-1 selectively.

Original language	English
Pages (from-to)	17-20
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	1
Issue number	1
DOIs	https://doi.org/10.1039/b209086d
Publication status	Published - 07-01-2003
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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abstract = "A fluorescent probe for the detection of a metallo-β-lactamase (IMP-1), N-[2-(5-dimethylaminonaphthalen-1-ylsulfonylamino)ethyl]-3-mercaptopropionamide (Dansyl-C2SH), 1, was designed based on combining the inhibitory function of mercaptocarboxylate and a fluorophore. The binding of 1 to IMP-1 was investigated by fluorescence spectroscopy. Compound 1 can act as fluorescent probe for detecting IMP-1 selectively.",

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AU - Kurosaki, Hiromasa

AU - Yasuzawa, Hisami

AU - Yamaguchi, Yoshihiro

AU - Jin, Wanchun

AU - Arakawa, Yoshichika

AU - Goto, Masafumi

PY - 2003/1/7

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Detection of a metallo-β-lactamase (IMP-1) by fluorescent probes having dansyl and thiol groups

Abstract

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