Detection of an immature dentate gyrus feature in human schizophrenia/bipolar patients

N. M. Walton, Y. Zhou, J. H. Kogan, R. Shin, M. Webster, A. K. Gross, C. L. Heusner, Q. Chen, S. Miyake, K. Tajinda, K. Tamura, T. Miyakawa, M. Matsumoto

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Hippocampus-associated cognitive impairments are a common, highly conserved symptom of both schizophrenia (SCZ) and bipolar disorder (BPD). Although the hippocampus is likely an impacted region in SCZ/BPD patients, the molecular and cellular underpinnings of these impairments are difficult to identify. An emerging class of mouse models for these psychiatric diseases display similar cognitive impairments to those observed in human patients. The hippocampi of these mice possess a conserved pathophysiological alteration; we term the 'immature dentate gyrus' (iDG), characterized by increased numbers of calretinin-positive immature neuronal progenitors, a dearth of calbindin-positive mature neurons and (often) constitutively increased neurogenesis. Although these models provide a link between cellular dysfunction and behavioral alteration, limited translational validity exists linking the iDG to human pathophysiology. In this study, we report the initial identification of an iDG-like phenotype in the hippocampi of human SCZ/BPD patients. These findings suggest a new motif for the etiology of these diseases and link an emerging class of mouse models to the human disease condition.

Original languageEnglish
Pages (from-to)e135
JournalTranslational psychiatry
Volume2
DOIs
Publication statusPublished - 17-07-2012

Fingerprint

Dentate Gyrus
Hippocampus
Schizophrenia
Bipolar Disorder
Calbindin 2
Calbindins
Neurogenesis
Psychiatry
Phenotype
Neurons
Cognitive Dysfunction

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Biological Psychiatry

Cite this

Walton, N. M., Zhou, Y., Kogan, J. H., Shin, R., Webster, M., Gross, A. K., ... Matsumoto, M. (2012). Detection of an immature dentate gyrus feature in human schizophrenia/bipolar patients. Translational psychiatry, 2, e135. https://doi.org/10.1038/tp.2012.56
Walton, N. M. ; Zhou, Y. ; Kogan, J. H. ; Shin, R. ; Webster, M. ; Gross, A. K. ; Heusner, C. L. ; Chen, Q. ; Miyake, S. ; Tajinda, K. ; Tamura, K. ; Miyakawa, T. ; Matsumoto, M. / Detection of an immature dentate gyrus feature in human schizophrenia/bipolar patients. In: Translational psychiatry. 2012 ; Vol. 2. pp. e135.
@article{909e15ab8c6241e2ae1f53ebdd3698d9,
title = "Detection of an immature dentate gyrus feature in human schizophrenia/bipolar patients",
abstract = "Hippocampus-associated cognitive impairments are a common, highly conserved symptom of both schizophrenia (SCZ) and bipolar disorder (BPD). Although the hippocampus is likely an impacted region in SCZ/BPD patients, the molecular and cellular underpinnings of these impairments are difficult to identify. An emerging class of mouse models for these psychiatric diseases display similar cognitive impairments to those observed in human patients. The hippocampi of these mice possess a conserved pathophysiological alteration; we term the 'immature dentate gyrus' (iDG), characterized by increased numbers of calretinin-positive immature neuronal progenitors, a dearth of calbindin-positive mature neurons and (often) constitutively increased neurogenesis. Although these models provide a link between cellular dysfunction and behavioral alteration, limited translational validity exists linking the iDG to human pathophysiology. In this study, we report the initial identification of an iDG-like phenotype in the hippocampi of human SCZ/BPD patients. These findings suggest a new motif for the etiology of these diseases and link an emerging class of mouse models to the human disease condition.",
author = "Walton, {N. M.} and Y. Zhou and Kogan, {J. H.} and R. Shin and M. Webster and Gross, {A. K.} and Heusner, {C. L.} and Q. Chen and S. Miyake and K. Tajinda and K. Tamura and T. Miyakawa and M. Matsumoto",
year = "2012",
month = "7",
day = "17",
doi = "10.1038/tp.2012.56",
language = "English",
volume = "2",
pages = "e135",
journal = "Translational Psychiatry",
issn = "2158-3188",
publisher = "Nature Publishing Group",

}

Walton, NM, Zhou, Y, Kogan, JH, Shin, R, Webster, M, Gross, AK, Heusner, CL, Chen, Q, Miyake, S, Tajinda, K, Tamura, K, Miyakawa, T & Matsumoto, M 2012, 'Detection of an immature dentate gyrus feature in human schizophrenia/bipolar patients', Translational psychiatry, vol. 2, pp. e135. https://doi.org/10.1038/tp.2012.56

Detection of an immature dentate gyrus feature in human schizophrenia/bipolar patients. / Walton, N. M.; Zhou, Y.; Kogan, J. H.; Shin, R.; Webster, M.; Gross, A. K.; Heusner, C. L.; Chen, Q.; Miyake, S.; Tajinda, K.; Tamura, K.; Miyakawa, T.; Matsumoto, M.

In: Translational psychiatry, Vol. 2, 17.07.2012, p. e135.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Detection of an immature dentate gyrus feature in human schizophrenia/bipolar patients

AU - Walton, N. M.

AU - Zhou, Y.

AU - Kogan, J. H.

AU - Shin, R.

AU - Webster, M.

AU - Gross, A. K.

AU - Heusner, C. L.

AU - Chen, Q.

AU - Miyake, S.

AU - Tajinda, K.

AU - Tamura, K.

AU - Miyakawa, T.

AU - Matsumoto, M.

PY - 2012/7/17

Y1 - 2012/7/17

N2 - Hippocampus-associated cognitive impairments are a common, highly conserved symptom of both schizophrenia (SCZ) and bipolar disorder (BPD). Although the hippocampus is likely an impacted region in SCZ/BPD patients, the molecular and cellular underpinnings of these impairments are difficult to identify. An emerging class of mouse models for these psychiatric diseases display similar cognitive impairments to those observed in human patients. The hippocampi of these mice possess a conserved pathophysiological alteration; we term the 'immature dentate gyrus' (iDG), characterized by increased numbers of calretinin-positive immature neuronal progenitors, a dearth of calbindin-positive mature neurons and (often) constitutively increased neurogenesis. Although these models provide a link between cellular dysfunction and behavioral alteration, limited translational validity exists linking the iDG to human pathophysiology. In this study, we report the initial identification of an iDG-like phenotype in the hippocampi of human SCZ/BPD patients. These findings suggest a new motif for the etiology of these diseases and link an emerging class of mouse models to the human disease condition.

AB - Hippocampus-associated cognitive impairments are a common, highly conserved symptom of both schizophrenia (SCZ) and bipolar disorder (BPD). Although the hippocampus is likely an impacted region in SCZ/BPD patients, the molecular and cellular underpinnings of these impairments are difficult to identify. An emerging class of mouse models for these psychiatric diseases display similar cognitive impairments to those observed in human patients. The hippocampi of these mice possess a conserved pathophysiological alteration; we term the 'immature dentate gyrus' (iDG), characterized by increased numbers of calretinin-positive immature neuronal progenitors, a dearth of calbindin-positive mature neurons and (often) constitutively increased neurogenesis. Although these models provide a link between cellular dysfunction and behavioral alteration, limited translational validity exists linking the iDG to human pathophysiology. In this study, we report the initial identification of an iDG-like phenotype in the hippocampi of human SCZ/BPD patients. These findings suggest a new motif for the etiology of these diseases and link an emerging class of mouse models to the human disease condition.

UR - http://www.scopus.com/inward/record.url?scp=84863765596&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863765596&partnerID=8YFLogxK

U2 - 10.1038/tp.2012.56

DO - 10.1038/tp.2012.56

M3 - Article

C2 - 22781168

AN - SCOPUS:84863765596

VL - 2

SP - e135

JO - Translational Psychiatry

JF - Translational Psychiatry

SN - 2158-3188

ER -