TY - JOUR
T1 - Detection of doxorubicin cardiotoxicity by using iodine-123 BMIPP early dynamic SPECT
T2 - Quantitative evaluation of early abnormality of fatty acid metabolism with the Rutland method
AU - Saito, Kimimasa
AU - Takeda, Kan
AU - Okamoto, Shinya
AU - Okamoto, Ryuzi
AU - Makino, Katutoshi
AU - Tameda, Yukihito
AU - Nomura, Yoshiyuki
AU - Maeda, Hisato
AU - Ichihara, Takashi
AU - Nakano, Takeshi
PY - 2000/11
Y1 - 2000/11
N2 - Background. To evaluate the possibility of predicting the development of doxorubicin-induced cardiomyopathy, we performed quantitative assessment of the early kinetics of iodine-123 betamethyl-iodophenyl-pentadecanoic acid (I-123 BMIPP) by means of dynamic myocardial SPECT. Methods. Thirty-six patients with various malignancies were examined. I-123 BMIPP dynamic myocardial SPECT was performed before chemotherapy, after chemotherapy, or both. Immediately after the injection of I-123 BMIPP (111 MBq), 30-second dynamic SPECT data were acquired successively for 15 minutes. The left ventricular (LV) myocardium was divided into 8 segments in short-axial and vertical slices. By using the time-activity curve (TAC) of each myocardial segment [Mo(t)] as an output function and the TAC of the LV cavity [B(t)] as an input function, the Rutland equation, Mo(t)/B(t)= F + K ∫B(t)dt/B(t), was used as means of assessing all segments. Results. Mo(t)/B(t) showed a good linear correlation with ∫B(t)dt/B(t) from 30 seconds to 4 minutes in all 456 segments. The mean K value of 8 LV segments was significantly lower after chemotherapy than before chemotherapy (0.071 ± 0.019 [n = 21] vs 0.095 ± 0.025 [n = 36], P< .001). In 21 patients in whom dynamic SPECT was performed both before and after chemotherapy, the mean K values of left ventricle showed a significant decrease, from 0.101 ± 0.024 to 0.071 ± 0.019 (P <.0001). The fractional change in the value of K after chemotherapy showed a significant linear correlation with the administered dose of doxorubicin (r = 0.648, P <.002). Conclusion. I-123 BMIPP dynamic myocardial SPECT may be clinically useful, because it permits the early detection of doxorubicin-induced cardiomyopathy.
AB - Background. To evaluate the possibility of predicting the development of doxorubicin-induced cardiomyopathy, we performed quantitative assessment of the early kinetics of iodine-123 betamethyl-iodophenyl-pentadecanoic acid (I-123 BMIPP) by means of dynamic myocardial SPECT. Methods. Thirty-six patients with various malignancies were examined. I-123 BMIPP dynamic myocardial SPECT was performed before chemotherapy, after chemotherapy, or both. Immediately after the injection of I-123 BMIPP (111 MBq), 30-second dynamic SPECT data were acquired successively for 15 minutes. The left ventricular (LV) myocardium was divided into 8 segments in short-axial and vertical slices. By using the time-activity curve (TAC) of each myocardial segment [Mo(t)] as an output function and the TAC of the LV cavity [B(t)] as an input function, the Rutland equation, Mo(t)/B(t)= F + K ∫B(t)dt/B(t), was used as means of assessing all segments. Results. Mo(t)/B(t) showed a good linear correlation with ∫B(t)dt/B(t) from 30 seconds to 4 minutes in all 456 segments. The mean K value of 8 LV segments was significantly lower after chemotherapy than before chemotherapy (0.071 ± 0.019 [n = 21] vs 0.095 ± 0.025 [n = 36], P< .001). In 21 patients in whom dynamic SPECT was performed both before and after chemotherapy, the mean K values of left ventricle showed a significant decrease, from 0.101 ± 0.024 to 0.071 ± 0.019 (P <.0001). The fractional change in the value of K after chemotherapy showed a significant linear correlation with the administered dose of doxorubicin (r = 0.648, P <.002). Conclusion. I-123 BMIPP dynamic myocardial SPECT may be clinically useful, because it permits the early detection of doxorubicin-induced cardiomyopathy.
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U2 - 10.1067/mnc.2000.108351
DO - 10.1067/mnc.2000.108351
M3 - Article
C2 - 11144469
AN - SCOPUS:17744382573
SN - 1071-3581
VL - 7
SP - 553
EP - 561
JO - Journal of Nuclear Cardiology
JF - Journal of Nuclear Cardiology
IS - 6
ER -