TY - JOUR
T1 - Detection of loci for allergic asthma using SMXA recombinant inbred strains of mice
AU - Ohno, Tamio
AU - Okamoto, Masakazu
AU - Hara, Toru
AU - Hashimoto, Naozumi
AU - Imaizumi, Kazuyoshi
AU - Matsushima, Miyoko
AU - Nishimura, Masahiko
AU - Shimokata, Kaoru
AU - Hasegawa, Yoshinori
AU - Kawabe, Tsutomu
N1 - Funding Information:
Acknowledgments The authors would like to thank Ms. Keiko Shimamoto and Ms. Ayako Asai for their technical assistance. Supported in part by a Grant-in-Aid for Scientific Research (Genome), Ministry of Education, Culture, Sports, Science and Technology, Japan.
PY - 2013/1
Y1 - 2013/1
N2 - Asthma is regarded as a multifactorial inflammatory disorder arising as a result of inappropriate immune responses in genetically susceptible individuals to common environmental antigens. However, the precise molecular basis is unknown. To identify genes for susceptibility to three asthma-related traits, airway hyperresponsiveness (AHR), eosinophil infiltration, and allergen-specific serum IgE levels, we conducted a genetic analysis using SMXA recombinant inbred (RI) strains of mice. Quantitative trait locus analysis detected a significant locus for AHR on chromosome 17. For eosinophil infiltration, significant loci were detected on chromosomes 9 and 16. Although we could not detect any significant loci for allergen-specific serum IgE, analysis of consomic strains showed that chromosomes 17 and 19 carried genes that affected this trait. We detected genetic susceptibility loci that separately regulated the three asthma-related phenotypes. Our results suggested that different genetic mechanisms regulate these asthma-related phenotypes. Genetic analyses using murine RI and consomic strains enhance understanding of the molecular mechanisms of asthma in human.
AB - Asthma is regarded as a multifactorial inflammatory disorder arising as a result of inappropriate immune responses in genetically susceptible individuals to common environmental antigens. However, the precise molecular basis is unknown. To identify genes for susceptibility to three asthma-related traits, airway hyperresponsiveness (AHR), eosinophil infiltration, and allergen-specific serum IgE levels, we conducted a genetic analysis using SMXA recombinant inbred (RI) strains of mice. Quantitative trait locus analysis detected a significant locus for AHR on chromosome 17. For eosinophil infiltration, significant loci were detected on chromosomes 9 and 16. Although we could not detect any significant loci for allergen-specific serum IgE, analysis of consomic strains showed that chromosomes 17 and 19 carried genes that affected this trait. We detected genetic susceptibility loci that separately regulated the three asthma-related phenotypes. Our results suggested that different genetic mechanisms regulate these asthma-related phenotypes. Genetic analyses using murine RI and consomic strains enhance understanding of the molecular mechanisms of asthma in human.
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U2 - 10.1007/s00251-012-0656-7
DO - 10.1007/s00251-012-0656-7
M3 - Article
C2 - 23081743
AN - SCOPUS:84872330600
SN - 0093-7711
VL - 65
SP - 17
EP - 24
JO - Immunogenetics
JF - Immunogenetics
IS - 1
ER -