Detection of new anti-neutral glycosphingolipids antibodies and their effects on Trk neurotrophin receptors

T. Mihara, Akihiro Ueda, M. Hirayama, T. Takeuchi, S. Yoshida, K. Naito, H. Yamamoto, T. Mutoh

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We screened sera from patients with various neurological disorders for the presence of anti-neutral glycosphingolipids antibodies and only found them in sera from relapsing polychondritis with limbic encephalitis patients. Neutral glycosphingolipids are resident in membrane lipid rafts where high affinity nerve growth factor (NGF) receptor, Trk is co-localized. Therefore, we examined whether these antibodies influence the action of NGF in NGF-responsive cells. The results strongly suggest that these antibodies enhance NGF-induced Trk autophosphorylation and neurite outgrowth as well as neurofilament M expression. These data strongly indicate that these anti-neutral glycosphingolipids antibodies have an functional impact on NGF-Trk-mediated intracellular signal transduction pathway.

Original languageEnglish
Pages (from-to)4991-4995
Number of pages5
JournalFEBS Letters
Volume580
Issue number21
DOIs
Publication statusPublished - 18-09-2006

Fingerprint

Neutral Glycosphingolipids
Nerve Growth Factor Receptors
Nerve Growth Factor
Antibodies
Limbic Encephalitis
Relapsing Polychondritis
Nerve Growth Factor Receptor
Signal transduction
Intermediate Filaments
Membrane Lipids
Nervous System Diseases
Serum
Signal Transduction

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Mihara, T. ; Ueda, Akihiro ; Hirayama, M. ; Takeuchi, T. ; Yoshida, S. ; Naito, K. ; Yamamoto, H. ; Mutoh, T. / Detection of new anti-neutral glycosphingolipids antibodies and their effects on Trk neurotrophin receptors. In: FEBS Letters. 2006 ; Vol. 580, No. 21. pp. 4991-4995.
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Mihara, T, Ueda, A, Hirayama, M, Takeuchi, T, Yoshida, S, Naito, K, Yamamoto, H & Mutoh, T 2006, 'Detection of new anti-neutral glycosphingolipids antibodies and their effects on Trk neurotrophin receptors', FEBS Letters, vol. 580, no. 21, pp. 4991-4995. https://doi.org/10.1016/j.febslet.2006.08.013

Detection of new anti-neutral glycosphingolipids antibodies and their effects on Trk neurotrophin receptors. / Mihara, T.; Ueda, Akihiro; Hirayama, M.; Takeuchi, T.; Yoshida, S.; Naito, K.; Yamamoto, H.; Mutoh, T.

In: FEBS Letters, Vol. 580, No. 21, 18.09.2006, p. 4991-4995.

Research output: Contribution to journalArticle

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AU - Mihara, T.

AU - Ueda, Akihiro

AU - Hirayama, M.

AU - Takeuchi, T.

AU - Yoshida, S.

AU - Naito, K.

AU - Yamamoto, H.

AU - Mutoh, T.

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