Detection of plasmid-mediated class C β-lactamases

Yohei Doi, David L. Paterson

Research output: Contribution to journalReview article

67 Citations (Scopus)

Abstract

Plasmid-mediated class C β-lactamases are reported from Enterobacteriaceae with increasing frequency. They likely originate from chromosomal AmpC of certain Gram-negative bacterial species and subsequently are mobilized onto transmissible plasmids. There are reports of unfavorable clinical outcomes in patients infected with these organisms and treated with broad-spectrum cephalosporins. However, unlike class A extended-spectrum β-lactamases (ESBLs), no screening and confirmatory tests have been uniformly established for strains that produce class C β-lactamases. Reduced susceptibility to cefoxitin is a sensitive but not specific indicator of class C β-lactamase production. Simple confirmatory tests including tests using boronic acid compounds as specific class C β-lactamase inhibitors have recently been developed. Their utilization will enable clinical microbiology laboratories to report those strains producing plasmid-mediated class C β-lactamases as being resistant to all broad-spectrum cephalosporins, thus allowing physicians to prescribe appropriate antimicrobial therapy.

Original languageEnglish
Pages (from-to)191-197
Number of pages7
JournalInternational Journal of Infectious Diseases
Volume11
Issue number3
DOIs
Publication statusPublished - 01-05-2007
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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