Determination of Kt/V and protein catabolic rate using pre- and postdialysis blood urea nitrogen concentrations

T. Shinzato, S. Nakai, Y. Fujita, I. Takai, H. Morita, K. Nakane, K. Maeda

Research output: Contribution to journalArticlepeer-review

128 Citations (Scopus)


We developed a new urea kinetic method for simultaneous determination of the Kt/V and protein catabolic rate (PCR) only from blood urea nitrogen (BUN) concentrations before and after a single dialysis session. Using this method, the parameters were calculated within 1.5 s even when a hand-held computer with a low central processing capacity is used. The total amount of urea eliminated during three dialysis sessions in 1 week is assumed to be equal to urea volume (G(w)) generated over a 1-week period (T(w)): GW = G x T, = K?0(T)C1dt + ?(o)(T) C2dt +?(o)(T) C3dt. Here, G is the generation rate, K is the dialyzer urea clearance, T is the dialysis time and C1, C2 and C3 are BUN during the respective dialysis session. If this equation and the equation expressing the urea kinetics during a single dialysis session are solved together, we have a solution for Kt/V and G. The thus-obtained Kt/V and G are corrected using the change in body weight. The corrected Kt/V showed a good correspondence with the parameter calculated with the classical method, and the midweek PCR derived from G determined by the present method being equivalent to the PCR averaged for a 1-week period determined by the classical methods.

Original languageEnglish
Pages (from-to)280-290
Number of pages11
Issue number3
Publication statusPublished - 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physiology
  • Nephrology
  • Physiology (medical)
  • Urology


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