TY - JOUR
T1 - Development and endoscopic appearance of colorectal tumors are characterized by the expression profiles of miRNAs
AU - Nakagawa, Yoshihito
AU - Akao, Yukihiro
AU - Tahara, Tomomitsu
AU - Yamashita, Hiromi
AU - Nagasaka, Mitsuo
AU - Shibata, Tomoyuki
AU - Ohmiya, Naoki
N1 - Publisher Copyright:
© 2018, The Japanese Society for Clinical Molecular Morphology.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Accumulating data indicates that certain microRNAs (miRNAs or miRs) are differently expressed in samples of tumors and paired non-tumorous samples taken from the same patients with colorectal tumors. We previously reported to clarify the relationship between the expression of the miRNAs and the endoscopic morphological appearance of the colorectal tumors. In this report, we focused on colorectal adenoma (tubular or tubulovillous adenoma), or tubular early carcinoma or type 2 adenocarcinoma, familial adenomatous polyposis (FAP), ulcerative colitis-associated tumor (UCAT), and sessile serrated adenoma/polyp (SSA/P). We tried to clarify the relationship between the expression of the miRNAs and the colorectal tumor development. The expression levels of miR-143, -145, and -34a were reduced in most of the polypoid and FAP tumors compared with those in the flat elevated, UCAT, SSA/P ones. In type 2 adenocarcinomas, the expression profile of these miRNAs was similar to those of the polypoid and FAP tumors. The expression levels of miR-7 and -21 were up-regulated in non-granular type of laterally spreading tumor, UCAT, and SSA/P compared with those in polypoid and FAP tumors. These findings indicated that the expression of onco-related miRNAs was closely associated with the development and endoscopic appearance of colorectal tumors.
AB - Accumulating data indicates that certain microRNAs (miRNAs or miRs) are differently expressed in samples of tumors and paired non-tumorous samples taken from the same patients with colorectal tumors. We previously reported to clarify the relationship between the expression of the miRNAs and the endoscopic morphological appearance of the colorectal tumors. In this report, we focused on colorectal adenoma (tubular or tubulovillous adenoma), or tubular early carcinoma or type 2 adenocarcinoma, familial adenomatous polyposis (FAP), ulcerative colitis-associated tumor (UCAT), and sessile serrated adenoma/polyp (SSA/P). We tried to clarify the relationship between the expression of the miRNAs and the colorectal tumor development. The expression levels of miR-143, -145, and -34a were reduced in most of the polypoid and FAP tumors compared with those in the flat elevated, UCAT, SSA/P ones. In type 2 adenocarcinomas, the expression profile of these miRNAs was similar to those of the polypoid and FAP tumors. The expression levels of miR-7 and -21 were up-regulated in non-granular type of laterally spreading tumor, UCAT, and SSA/P compared with those in polypoid and FAP tumors. These findings indicated that the expression of onco-related miRNAs was closely associated with the development and endoscopic appearance of colorectal tumors.
KW - Adenoma–carcinoma sequence
KW - Colorectal tumor development
KW - Flat elevated tumor
KW - Onco-related microRNA
KW - Sessile serrated adenoma/polyp
KW - Ulcerative colitis-associated tumor
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U2 - 10.1007/s00795-018-0186-y
DO - 10.1007/s00795-018-0186-y
M3 - Review article
C2 - 29564561
AN - SCOPUS:85044242933
SN - 1860-1480
VL - 51
SP - 82
EP - 88
JO - Medical Molecular Morphology
JF - Medical Molecular Morphology
IS - 2
ER -