Development and endoscopic appearance of colorectal tumors are characterized by the expression profiles of miRNAs

Yoshihito Nakagawa, Yukihiro Akao, Tomomitsu Tahara, Hiromi Yamashita, Mitsuo Nagasaka, Tomoyuki Shibata, Naoki Omiya

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Accumulating data indicates that certain microRNAs (miRNAs or miRs) are differently expressed in samples of tumors and paired non-tumorous samples taken from the same patients with colorectal tumors. We previously reported to clarify the relationship between the expression of the miRNAs and the endoscopic morphological appearance of the colorectal tumors. In this report, we focused on colorectal adenoma (tubular or tubulovillous adenoma), or tubular early carcinoma or type 2 adenocarcinoma, familial adenomatous polyposis (FAP), ulcerative colitis-associated tumor (UCAT), and sessile serrated adenoma/polyp (SSA/P). We tried to clarify the relationship between the expression of the miRNAs and the colorectal tumor development. The expression levels of miR-143, -145, and -34a were reduced in most of the polypoid and FAP tumors compared with those in the flat elevated, UCAT, SSA/P ones. In type 2 adenocarcinomas, the expression profile of these miRNAs was similar to those of the polypoid and FAP tumors. The expression levels of miR-7 and -21 were up-regulated in non-granular type of laterally spreading tumor, UCAT, and SSA/P compared with those in polypoid and FAP tumors. These findings indicated that the expression of onco-related miRNAs was closely associated with the development and endoscopic appearance of colorectal tumors.

Original languageEnglish
Pages (from-to)82-88
Number of pages7
JournalMedical Molecular Morphology
Volume51
Issue number2
DOIs
Publication statusPublished - 01-06-2018

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MicroRNAs
Colorectal Neoplasms
Adenomatous Polyposis Coli
Adenoma
Neoplasms
Polyps
Ulcerative Colitis
Adenocarcinoma

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Molecular Biology

Cite this

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title = "Development and endoscopic appearance of colorectal tumors are characterized by the expression profiles of miRNAs",
abstract = "Accumulating data indicates that certain microRNAs (miRNAs or miRs) are differently expressed in samples of tumors and paired non-tumorous samples taken from the same patients with colorectal tumors. We previously reported to clarify the relationship between the expression of the miRNAs and the endoscopic morphological appearance of the colorectal tumors. In this report, we focused on colorectal adenoma (tubular or tubulovillous adenoma), or tubular early carcinoma or type 2 adenocarcinoma, familial adenomatous polyposis (FAP), ulcerative colitis-associated tumor (UCAT), and sessile serrated adenoma/polyp (SSA/P). We tried to clarify the relationship between the expression of the miRNAs and the colorectal tumor development. The expression levels of miR-143, -145, and -34a were reduced in most of the polypoid and FAP tumors compared with those in the flat elevated, UCAT, SSA/P ones. In type 2 adenocarcinomas, the expression profile of these miRNAs was similar to those of the polypoid and FAP tumors. The expression levels of miR-7 and -21 were up-regulated in non-granular type of laterally spreading tumor, UCAT, and SSA/P compared with those in polypoid and FAP tumors. These findings indicated that the expression of onco-related miRNAs was closely associated with the development and endoscopic appearance of colorectal tumors.",
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Development and endoscopic appearance of colorectal tumors are characterized by the expression profiles of miRNAs. / Nakagawa, Yoshihito; Akao, Yukihiro; Tahara, Tomomitsu; Yamashita, Hiromi; Nagasaka, Mitsuo; Shibata, Tomoyuki; Omiya, Naoki.

In: Medical Molecular Morphology, Vol. 51, No. 2, 01.06.2018, p. 82-88.

Research output: Contribution to journalReview article

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AU - Nakagawa, Yoshihito

AU - Akao, Yukihiro

AU - Tahara, Tomomitsu

AU - Yamashita, Hiromi

AU - Nagasaka, Mitsuo

AU - Shibata, Tomoyuki

AU - Omiya, Naoki

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