TY - JOUR
T1 - Development of σ-receptor ligands and clinical trials
AU - Nabeshima, T.
AU - Muraoka, I.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1999
Y1 - 1999
N2 - There are at least two classes of σ-receptors, termed σ1 and σ2. Recently, the σ1-receptor has been completely sequenced in different species. The amino acid sequences of the different purified proteins are highly homologous, but it shares no homology to know mammalian proteins. These results suggest that the σ1 receptor is a distinct entity from any often known receptors, σ-Receptors are involved in many physiological functions. Therefore, σ-ligands show many different pharmacological effects such as glucose utilization, neuroprotective, antipsychotic, antidepressive, anxiolytic, nootropic, antiepileptic, antiabuse, antitussive, antidiarrhea, anti-inflammatory, tear protein releasing stimulant and central anti- micturition reflex actions. These results suggest that σ-receptors are very promising targets for the development of new drugs that have new mechanisms of action.
AB - There are at least two classes of σ-receptors, termed σ1 and σ2. Recently, the σ1-receptor has been completely sequenced in different species. The amino acid sequences of the different purified proteins are highly homologous, but it shares no homology to know mammalian proteins. These results suggest that the σ1 receptor is a distinct entity from any often known receptors, σ-Receptors are involved in many physiological functions. Therefore, σ-ligands show many different pharmacological effects such as glucose utilization, neuroprotective, antipsychotic, antidepressive, anxiolytic, nootropic, antiepileptic, antiabuse, antitussive, antidiarrhea, anti-inflammatory, tear protein releasing stimulant and central anti- micturition reflex actions. These results suggest that σ-receptors are very promising targets for the development of new drugs that have new mechanisms of action.
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U2 - 10.1254/fpj.114.3
DO - 10.1254/fpj.114.3
M3 - Review article
C2 - 10562960
AN - SCOPUS:0032778430
SN - 0015-5691
VL - 114
SP - 3
EP - 11
JO - Folia Pharmacologica Japonica
JF - Folia Pharmacologica Japonica
IS - 1
ER -