Development of a target-directed magnetic resonance contrast agent using monoclonal antibody-conjugated magnetic particles.

M. Suzuki, H. Honda, T. Kobayashi, T. Wakabayashi, J. Yoshida, M. Takahashi

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

We developed a novel magnetic resonance (MR) imaging contrast agent, MAb-magnetite, that was prepared by covalently linking polyethylene glycol-coated magnetite to a monoclonal antibody specific for a human glioma cell-surface antigen. When MAb-magnetite was injected intravenously into tumor-bearing nude mice at a dose of 100 mumol Fe/kg body weight, a 50% decrease in the T2 signal intensity of the tumor was observed, immediately following administration and continued for 48 h. Microscopic observation of the tumor tissue demonstrated localization of MAb-magnetite in cancer cells. These results suggest that MAb-magnetite is a promising agent for MR imaging of neoplasms.

Original languageEnglish
Pages (from-to)127-132
Number of pages6
JournalNōshuyō byōri = Brain tumor pathology
Volume13
Issue number2
Publication statusPublished - 11-1996

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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