Development of aberrant crypt foci involves a fission mechanism as revealed by isolation of aberrant crypts

Yasunobu Fujimitsu, Hayao Nakanishi, Ken Ichi Inada, Takasuke Yamachika, Masutaro Ichinose, Hiroko Fukami, Masae Tatematsu

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

Morphological analysis of isolated colonic crypts in rats, postnatally, indicated that the crypts reproduce themselves by a fission mechanism, the division beginning at the crypt base and proceeding upwards until there are two separate crypts. Occasionally, before the separation is complete, a second fission process starts on one or both sides of a bifurcating crypt and a triple-branched or quadruple-branched crypt results. Analysis of isolated aberrant crypt foci (ACF) in rats treated with 1,2-dimethylhydrazine revealed that the development of ACF consisting of multiple crypts is also due to a fission mechanism. Initially, an indentation appears at the base of a single ACF crypt, with subsequent formation of a bifurcation and eventual crypt division.

Original languageEnglish
Pages (from-to)1199-1203
Number of pages5
JournalJapanese Journal of Cancer Research
Volume87
Issue number12
DOIs
Publication statusPublished - 12-1996

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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