Development of aberrant crypt foci involves a fission mechanism as revealed by isolation of aberrant crypts

Yasunobu Fujimitsu; Hayao Nakanishi; Ken Ichi Inada; Takasuke Yamachika; Masutaro Ichinose; Hiroko Fukami; Masae Tatematsu

doi:10.1111/j.1349-7006.1996.tb03133.x

Development of aberrant crypt foci involves a fission mechanism as revealed by isolation of aberrant crypts

Yasunobu Fujimitsu, Hayao Nakanishi, Ken Ichi Inada, Takasuke Yamachika, Masutaro Ichinose, Hiroko Fukami, Masae Tatematsu

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Morphological analysis of isolated colonic crypts in rats, postnatally, indicated that the crypts reproduce themselves by a fission mechanism, the division beginning at the crypt base and proceeding upwards until there are two separate crypts. Occasionally, before the separation is complete, a second fission process starts on one or both sides of a bifurcating crypt and a triple-branched or quadruple-branched crypt results. Analysis of isolated aberrant crypt foci (ACF) in rats treated with 1,2-dimethylhydrazine revealed that the development of ACF consisting of multiple crypts is also due to a fission mechanism. Initially, an indentation appears at the base of a single ACF crypt, with subsequent formation of a bifurcation and eventual crypt division.

Original language	English
Pages (from-to)	1199-1203
Number of pages	5
Journal	Japanese Journal of Cancer Research
Volume	87
Issue number	12
DOIs	https://doi.org/10.1111/j.1349-7006.1996.tb03133.x
Publication status	Published - 12-1996
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1349-7006.1996.tb03133.x

Cite this

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title = "Development of aberrant crypt foci involves a fission mechanism as revealed by isolation of aberrant crypts",

abstract = "Morphological analysis of isolated colonic crypts in rats, postnatally, indicated that the crypts reproduce themselves by a fission mechanism, the division beginning at the crypt base and proceeding upwards until there are two separate crypts. Occasionally, before the separation is complete, a second fission process starts on one or both sides of a bifurcating crypt and a triple-branched or quadruple-branched crypt results. Analysis of isolated aberrant crypt foci (ACF) in rats treated with 1,2-dimethylhydrazine revealed that the development of ACF consisting of multiple crypts is also due to a fission mechanism. Initially, an indentation appears at the base of a single ACF crypt, with subsequent formation of a bifurcation and eventual crypt division.",

author = "Yasunobu Fujimitsu and Hayao Nakanishi and Inada, {Ken Ichi} and Takasuke Yamachika and Masutaro Ichinose and Hiroko Fukami and Masae Tatematsu",

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AU - Fujimitsu, Yasunobu

AU - Nakanishi, Hayao

AU - Inada, Ken Ichi

AU - Yamachika, Takasuke

AU - Ichinose, Masutaro

AU - Fukami, Hiroko

AU - Tatematsu, Masae

PY - 1996/12

Y1 - 1996/12

N2 - Morphological analysis of isolated colonic crypts in rats, postnatally, indicated that the crypts reproduce themselves by a fission mechanism, the division beginning at the crypt base and proceeding upwards until there are two separate crypts. Occasionally, before the separation is complete, a second fission process starts on one or both sides of a bifurcating crypt and a triple-branched or quadruple-branched crypt results. Analysis of isolated aberrant crypt foci (ACF) in rats treated with 1,2-dimethylhydrazine revealed that the development of ACF consisting of multiple crypts is also due to a fission mechanism. Initially, an indentation appears at the base of a single ACF crypt, with subsequent formation of a bifurcation and eventual crypt division.

AB - Morphological analysis of isolated colonic crypts in rats, postnatally, indicated that the crypts reproduce themselves by a fission mechanism, the division beginning at the crypt base and proceeding upwards until there are two separate crypts. Occasionally, before the separation is complete, a second fission process starts on one or both sides of a bifurcating crypt and a triple-branched or quadruple-branched crypt results. Analysis of isolated aberrant crypt foci (ACF) in rats treated with 1,2-dimethylhydrazine revealed that the development of ACF consisting of multiple crypts is also due to a fission mechanism. Initially, an indentation appears at the base of a single ACF crypt, with subsequent formation of a bifurcation and eventual crypt division.

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Development of aberrant crypt foci involves a fission mechanism as revealed by isolation of aberrant crypts

Abstract

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