Development of an easily swallowed film formulation

Hideaki Okabe, Eiji Suzuki, Yusaku Sugiura, Kaisuke Yanagimoto, Yasunari Takanashi, Masaru Hoshi, Eiji Nogami, Kaname Nakahara, Toru Sekiguchi, Mikoto Baba, Eiichi Saito

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We have developed an easily swallowed film formulation that swells and turns into a jelly instantaneously upon absorption of a small amount of saliva. The formulation's structure comprises a gelating layer on both faces of a drug-containing layer, and this structure restrains the elution of a drug in the mouth. Swelling experiments confirmed the instantaneous gelation when the gelating layer absorbs purified water. Fifteen seconds after immersion in purified water, the bulk modulus of the film formulation was less than 500 N/m2, which is an appropriate value for easy swallowing by elderly people. A dissolution study confirmed the delayed dissolution of glimepiride as a model drug. In a clinical study, although the stagnation at the upper esophagus was observed with a gelatin capsule, the film formulation passed the esophagus and reached the stomach quickly.

Original languageEnglish
Pages (from-to)62-66
Number of pages5
JournalInternational Journal of Pharmaceutics
Volume355
Issue number1-2
DOIs
Publication statusPublished - 01-05-2008

Fingerprint

glimepiride
Esophagus
Pharmaceutical Preparations
Water
Immersion
Deglutition
Saliva
Capsules
Mouth
Stomach
gelatin film
Clinical Studies

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

Okabe, H., Suzuki, E., Sugiura, Y., Yanagimoto, K., Takanashi, Y., Hoshi, M., ... Saito, E. (2008). Development of an easily swallowed film formulation. International Journal of Pharmaceutics, 355(1-2), 62-66. https://doi.org/10.1016/j.ijpharm.2007.11.038
Okabe, Hideaki ; Suzuki, Eiji ; Sugiura, Yusaku ; Yanagimoto, Kaisuke ; Takanashi, Yasunari ; Hoshi, Masaru ; Nogami, Eiji ; Nakahara, Kaname ; Sekiguchi, Toru ; Baba, Mikoto ; Saito, Eiichi. / Development of an easily swallowed film formulation. In: International Journal of Pharmaceutics. 2008 ; Vol. 355, No. 1-2. pp. 62-66.
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Okabe, H, Suzuki, E, Sugiura, Y, Yanagimoto, K, Takanashi, Y, Hoshi, M, Nogami, E, Nakahara, K, Sekiguchi, T, Baba, M & Saito, E 2008, 'Development of an easily swallowed film formulation', International Journal of Pharmaceutics, vol. 355, no. 1-2, pp. 62-66. https://doi.org/10.1016/j.ijpharm.2007.11.038

Development of an easily swallowed film formulation. / Okabe, Hideaki; Suzuki, Eiji; Sugiura, Yusaku; Yanagimoto, Kaisuke; Takanashi, Yasunari; Hoshi, Masaru; Nogami, Eiji; Nakahara, Kaname; Sekiguchi, Toru; Baba, Mikoto; Saito, Eiichi.

In: International Journal of Pharmaceutics, Vol. 355, No. 1-2, 01.05.2008, p. 62-66.

Research output: Contribution to journalArticle

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AU - Nogami, Eiji

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AU - Saito, Eiichi

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Okabe H, Suzuki E, Sugiura Y, Yanagimoto K, Takanashi Y, Hoshi M et al. Development of an easily swallowed film formulation. International Journal of Pharmaceutics. 2008 May 1;355(1-2):62-66. https://doi.org/10.1016/j.ijpharm.2007.11.038