TY - JOUR
T1 - Development of an irradiation method for superficial tumours using a hydrogel bolus in an accelerator-based BNCT
AU - Sasaki, Akinori
AU - Tanaka, Hiroki
AU - Takata, Takushi
AU - Tamari, Yuki
AU - Watanabe, Tsubasa
AU - Hu, Naonori
AU - Kawabata, Shinji
AU - Kudo, Yoshihiro
AU - Mitsumoto, Toshinori
AU - Sakurai, Yoshinori
AU - Suzuki, Minoru
N1 - Publisher Copyright:
© 2021 The Author(s). Published by IOP Publishing Ltd.
PY - 2022/1
Y1 - 2022/1
N2 - The aim of this study is the development of an irradiation method for the treatment of superficial tumours using a hydrogel bolus to produce thermal neutrons in accelerator-based Boron Neutron Capture Therapy (BNCT). To evaluate the neutron moderating ability of a hydrogel bolus, a water phantom with a hydrogel bolus was irradiated with an epithermal neutron beam from a cyclotron-based epithermal neutron source. Phantom simulating irradiation to the plantar position was manufactured using three-dimensional printing technology to perform an irradiation test of a hydrogel bolus. Thermal neutron fluxes on the surface of a phantom were evaluated and the results were compared with the Monte Carlo-based Simulation Environment for Radiotherapy Applications (SERA) treatment planning software. It was confirmed that a hydrogel bolus had the same neutron moderating ability as water, and the calculation results from SERA aligned with the measured values within approximately 5%. Furthermore, it was confirmed that the thermal neutron flux decreased at the edge of the irradiation field. It was possible to uniformly irradiate thermal neutrons by increasing the bolus thickness at the edge of the irradiation field, thereby successfully determining uniform dose distribution. An irradiation method for superficial tumours using a hydrogel bolus in the accelerator-based BNCT was established.
AB - The aim of this study is the development of an irradiation method for the treatment of superficial tumours using a hydrogel bolus to produce thermal neutrons in accelerator-based Boron Neutron Capture Therapy (BNCT). To evaluate the neutron moderating ability of a hydrogel bolus, a water phantom with a hydrogel bolus was irradiated with an epithermal neutron beam from a cyclotron-based epithermal neutron source. Phantom simulating irradiation to the plantar position was manufactured using three-dimensional printing technology to perform an irradiation test of a hydrogel bolus. Thermal neutron fluxes on the surface of a phantom were evaluated and the results were compared with the Monte Carlo-based Simulation Environment for Radiotherapy Applications (SERA) treatment planning software. It was confirmed that a hydrogel bolus had the same neutron moderating ability as water, and the calculation results from SERA aligned with the measured values within approximately 5%. Furthermore, it was confirmed that the thermal neutron flux decreased at the edge of the irradiation field. It was possible to uniformly irradiate thermal neutrons by increasing the bolus thickness at the edge of the irradiation field, thereby successfully determining uniform dose distribution. An irradiation method for superficial tumours using a hydrogel bolus in the accelerator-based BNCT was established.
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U2 - 10.1088/2057-1976/ac3d73
DO - 10.1088/2057-1976/ac3d73
M3 - Article
C2 - 34823226
AN - SCOPUS:85122546386
SN - 2057-1976
VL - 8
JO - Biomedical Physics and Engineering Express
JF - Biomedical Physics and Engineering Express
IS - 1
M1 - 015015
ER -