Development of anti-dementia drugs: Present and future

Toshitaka Nabeshima, Kiyofumi Yamada, Yukihiro Noda, Masaya Hasegawa, Isao Muraoka

Research output: Contribution to journalArticle

Abstract

Senile dementia consists of cerebral vascular dementia and Alzheimer- type dementia. We review pharmacotherapy for senile dementia in the present and development of anti-dementia drugs in the present and future. Number of patients of cerebral vascular dementia is gradually decreased by control the risk factors such as hypertension, hyperlipemia, arteriosclerosis, diabetes. In the present we have only 3 anti-dementia drugs for Alzheimer-type dementia. All of them are cholinesterase inhibitors which prevent dysfunction of cholinergic neuronal system in Alzheimer-type dementia. Other cholinergic agonists and the drugs to non-cholinergic neuronal systems are under the clinical investigations. In future there are many possibilities to develop new drugs to related hypothesis of Alzheimer-type dementia such as inflammation, deficiency of estrogen, oxidative stress, β-amyloid toxicity, phosphorylation of tau protein, deficiency of neurotrophic factors etc.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalPharmacometrics
Volume59
Issue number1
Publication statusPublished - 01-03-2000
Externally publishedYes

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Dementia
Alzheimer Disease
Pharmaceutical Preparations
Vascular Dementia
Cholinergic Agents
Cholinergic Agonists
tau Proteins
Protein Deficiency
Arteriosclerosis
Cholinesterase Inhibitors
Nerve Growth Factors
Hyperlipidemias
Amyloid
Estrogens
Oxidative Stress
Phosphorylation
Hypertension
Inflammation
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Nabeshima, T., Yamada, K., Noda, Y., Hasegawa, M., & Muraoka, I. (2000). Development of anti-dementia drugs: Present and future. Pharmacometrics, 59(1), 1-9.
Nabeshima, Toshitaka ; Yamada, Kiyofumi ; Noda, Yukihiro ; Hasegawa, Masaya ; Muraoka, Isao. / Development of anti-dementia drugs : Present and future. In: Pharmacometrics. 2000 ; Vol. 59, No. 1. pp. 1-9.
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Nabeshima, T, Yamada, K, Noda, Y, Hasegawa, M & Muraoka, I 2000, 'Development of anti-dementia drugs: Present and future', Pharmacometrics, vol. 59, no. 1, pp. 1-9.

Development of anti-dementia drugs : Present and future. / Nabeshima, Toshitaka; Yamada, Kiyofumi; Noda, Yukihiro; Hasegawa, Masaya; Muraoka, Isao.

In: Pharmacometrics, Vol. 59, No. 1, 01.03.2000, p. 1-9.

Research output: Contribution to journalArticle

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Nabeshima T, Yamada K, Noda Y, Hasegawa M, Muraoka I. Development of anti-dementia drugs: Present and future. Pharmacometrics. 2000 Mar 1;59(1):1-9.