TY - GEN
T1 - Development of biodegradable scaffolds by leaching self-assembled magnetic sugar particles
AU - Takamatsu, Ryo
AU - Oura, Hiroyuki
AU - Uchida, Tomoyuki
AU - Ikeda, Seiichi
AU - Ami, Fumihito
AU - Negoro, Makoto
AU - Hayakawa, Motoharu
AU - Takahashi, Ikuo
AU - Fukuda, Toshio
PY - 2009
Y1 - 2009
N2 - Technologies to develop scaffolds with controlled diameter and high porosity have great significance in tissue engineer ing. We have fabricated biodegradable 2D and 3D scaffol ds with ordered array of pores by casting polymer on self -assembled d-fructose (sugar) microspheres. First, ferrite mi croparticles were encapsulated in sugar spheres to make th em become magnetized. After sieving magnetic sugar partic les, those diameter-controlled particles were attracted by a magnet to form a self-assembled template for polymer cas ting. After removal of sugar particles, ordered array of po res were generated on the surface of sheet-like scaffolds. O rdered pores are also generated in 3D tubular scaffolds by using magnetic force and viscoelasticity of PVA solution. It was confirmed that MSPs leaching method makes it pos sible to make high porous scaffolds in spite of the thicknes s of scaffold and the porosity is homogeneous. Finally, the biocompatibility of the developed scaffold was confirmed by the viability of human umbilical vein endothelial cells.
AB - Technologies to develop scaffolds with controlled diameter and high porosity have great significance in tissue engineer ing. We have fabricated biodegradable 2D and 3D scaffol ds with ordered array of pores by casting polymer on self -assembled d-fructose (sugar) microspheres. First, ferrite mi croparticles were encapsulated in sugar spheres to make th em become magnetized. After sieving magnetic sugar partic les, those diameter-controlled particles were attracted by a magnet to form a self-assembled template for polymer cas ting. After removal of sugar particles, ordered array of po res were generated on the surface of sheet-like scaffolds. O rdered pores are also generated in 3D tubular scaffolds by using magnetic force and viscoelasticity of PVA solution. It was confirmed that MSPs leaching method makes it pos sible to make high porous scaffolds in spite of the thicknes s of scaffold and the porosity is homogeneous. Finally, the biocompatibility of the developed scaffold was confirmed by the viability of human umbilical vein endothelial cells.
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U2 - 10.1109/MHS.2009.5351884
DO - 10.1109/MHS.2009.5351884
M3 - Conference contribution
AN - SCOPUS:77950924186
SN - 9781424450954
T3 - 20th Anniversary MHS 2009 and Micro-Nano Global COE - 2009 International Symposium on Micro-NanoMechatronics and Human Science
SP - 356
EP - 361
BT - 20th Anniversary MHS 2009 and Micro-Nano Global COE - 2009 International Symposium on Micro-NanoMechatronics and Human Science
T2 - 20th Anniversary MHS 2009 and Micro-Nano Global COE - 2009 International Symposium on Micro-NanoMechatronics and Human Science
Y2 - 8 November 2009 through 11 November 2009
ER -