Abstract
Development of tolerance to phencyclidine (PCP) was assessed in male ICR mice, using motor incoordination as a parameter. The implantation of a PCP (1-3 mg/ day/mouse for 1-5 days)-containing osmotic minipump, induced tolerance, as evidenced by a gradual reduction of the duration of motor incoordination. The degree of tolerance exhibited dose and time dependency. Even after the removal of the PCP pump (1 mg/day/mouse for 5 days), the tolerance remained to the same degree for at least 4 days. The hepatic microsomal cytochrome P-450, cytochrome b5 and nicotinamide adenine dinucleotide phosphatase (NADPH)-cyctochrome c reductase activities were found to be elevated in tolerant mice (2 mg/ day/mouse for 5 days). The half-life of PCP in the brains of tolerant mice was likewise decreased. These data indicate a dispositional tolerance for PCP. It appears that the administration of PCP by the osmotic minipump offers a convenient method for inducing PCP tolerance.
Original language | English |
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Pages (from-to) | 239-253 |
Number of pages | 15 |
Journal | Journal of Pharmacological Methods |
Volume | 7 |
Issue number | 3 |
DOIs | |
Publication status | Published - 05-1982 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Pharmacology