Abstract
Development of tolerance to phencyclidine (PCP) was assessed in male ICR mice, using motor incoordination as a parameter. The implantation of a PCP (1-3 mg/ day/mouse for 1-5 days)-containing osmotic minipump, induced tolerance, as evidenced by a gradual reduction of the duration of motor incoordination. The degree of tolerance exhibited dose and time dependency. Even after the removal of the PCP pump (1 mg/day/mouse for 5 days), the tolerance remained to the same degree for at least 4 days. The hepatic microsomal cytochrome P-450, cytochrome b5 and nicotinamide adenine dinucleotide phosphatase (NADPH)-cyctochrome c reductase activities were found to be elevated in tolerant mice (2 mg/ day/mouse for 5 days). The half-life of PCP in the brains of tolerant mice was likewise decreased. These data indicate a dispositional tolerance for PCP. It appears that the administration of PCP by the osmotic minipump offers a convenient method for inducing PCP tolerance.
| Original language | English |
|---|---|
| Pages (from-to) | 239-253 |
| Number of pages | 15 |
| Journal | Journal of Pharmacological Methods |
| Volume | 7 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 01-01-1982 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Pharmacology
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Development of dispositional tolerance to phencyclidine by osmotic minipump in the mouse. / Nabeshima, Toshitaka; Sivam, Subbiah P.; Tai, Christine Y.; Ho, Ing K.
In: Journal of Pharmacological Methods, Vol. 7, No. 3, 01.01.1982, p. 239-253.Research output: Contribution to journal › Article
TY - JOUR
T1 - Development of dispositional tolerance to phencyclidine by osmotic minipump in the mouse
AU - Nabeshima, Toshitaka
AU - Sivam, Subbiah P.
AU - Tai, Christine Y.
AU - Ho, Ing K.
PY - 1982/1/1
Y1 - 1982/1/1
N2 - Development of tolerance to phencyclidine (PCP) was assessed in male ICR mice, using motor incoordination as a parameter. The implantation of a PCP (1-3 mg/ day/mouse for 1-5 days)-containing osmotic minipump, induced tolerance, as evidenced by a gradual reduction of the duration of motor incoordination. The degree of tolerance exhibited dose and time dependency. Even after the removal of the PCP pump (1 mg/day/mouse for 5 days), the tolerance remained to the same degree for at least 4 days. The hepatic microsomal cytochrome P-450, cytochrome b5 and nicotinamide adenine dinucleotide phosphatase (NADPH)-cyctochrome c reductase activities were found to be elevated in tolerant mice (2 mg/ day/mouse for 5 days). The half-life of PCP in the brains of tolerant mice was likewise decreased. These data indicate a dispositional tolerance for PCP. It appears that the administration of PCP by the osmotic minipump offers a convenient method for inducing PCP tolerance.
AB - Development of tolerance to phencyclidine (PCP) was assessed in male ICR mice, using motor incoordination as a parameter. The implantation of a PCP (1-3 mg/ day/mouse for 1-5 days)-containing osmotic minipump, induced tolerance, as evidenced by a gradual reduction of the duration of motor incoordination. The degree of tolerance exhibited dose and time dependency. Even after the removal of the PCP pump (1 mg/day/mouse for 5 days), the tolerance remained to the same degree for at least 4 days. The hepatic microsomal cytochrome P-450, cytochrome b5 and nicotinamide adenine dinucleotide phosphatase (NADPH)-cyctochrome c reductase activities were found to be elevated in tolerant mice (2 mg/ day/mouse for 5 days). The half-life of PCP in the brains of tolerant mice was likewise decreased. These data indicate a dispositional tolerance for PCP. It appears that the administration of PCP by the osmotic minipump offers a convenient method for inducing PCP tolerance.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020448906&partnerID=8YFLogxK
U2 - 10.1016/0160-5402(82)90040-7
DO - 10.1016/0160-5402(82)90040-7
M3 - Article
VL - 7
SP - 239
EP - 253
JO - Journal of Pharmacological and Toxicological Methods
JF - Journal of Pharmacological and Toxicological Methods
SN - 1056-8719
IS - 3
ER -