TY - JOUR
T1 - Development of dispositional tolerance to phencyclidine by osmotic minipump in the mouse
AU - Toshitaka, Nabeshima
AU - Sivam, Subbiah P.
AU - Tai, Christine Y.
AU - Ho, Ing K.
N1 - Funding Information:
These studies were supported by Grant DA-01403 from the National Institute on Drug Abuse.
PY - 1982/5
Y1 - 1982/5
N2 - Development of tolerance to phencyclidine (PCP) was assessed in male ICR mice, using motor incoordination as a parameter. The implantation of a PCP (1-3 mg/ day/mouse for 1-5 days)-containing osmotic minipump, induced tolerance, as evidenced by a gradual reduction of the duration of motor incoordination. The degree of tolerance exhibited dose and time dependency. Even after the removal of the PCP pump (1 mg/day/mouse for 5 days), the tolerance remained to the same degree for at least 4 days. The hepatic microsomal cytochrome P-450, cytochrome b5 and nicotinamide adenine dinucleotide phosphatase (NADPH)-cyctochrome c reductase activities were found to be elevated in tolerant mice (2 mg/ day/mouse for 5 days). The half-life of PCP in the brains of tolerant mice was likewise decreased. These data indicate a dispositional tolerance for PCP. It appears that the administration of PCP by the osmotic minipump offers a convenient method for inducing PCP tolerance.
AB - Development of tolerance to phencyclidine (PCP) was assessed in male ICR mice, using motor incoordination as a parameter. The implantation of a PCP (1-3 mg/ day/mouse for 1-5 days)-containing osmotic minipump, induced tolerance, as evidenced by a gradual reduction of the duration of motor incoordination. The degree of tolerance exhibited dose and time dependency. Even after the removal of the PCP pump (1 mg/day/mouse for 5 days), the tolerance remained to the same degree for at least 4 days. The hepatic microsomal cytochrome P-450, cytochrome b5 and nicotinamide adenine dinucleotide phosphatase (NADPH)-cyctochrome c reductase activities were found to be elevated in tolerant mice (2 mg/ day/mouse for 5 days). The half-life of PCP in the brains of tolerant mice was likewise decreased. These data indicate a dispositional tolerance for PCP. It appears that the administration of PCP by the osmotic minipump offers a convenient method for inducing PCP tolerance.
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U2 - 10.1016/0160-5402(82)90040-7
DO - 10.1016/0160-5402(82)90040-7
M3 - Article
C2 - 7109647
AN - SCOPUS:0020448906
VL - 7
SP - 239
EP - 253
JO - Journal of Pharmacological and Toxicological Methods
JF - Journal of Pharmacological and Toxicological Methods
SN - 1056-8719
IS - 3
ER -