Abstract
Aldehyde dehydrogenase (ALDH) is overexpressed in some subpopulations of stem cells and cancer cells. We have designed and synthesized the first selective fluorescent probe for class 3 ALDH (ALDH3A1). This probe enabled the visualization of ALDH3A1-positive cells by fluorescence microscopy as well as flow-cytometric isolation of ALDH3A1-positive viable cells from a human Caucasian esophageal squamous cell line (OE21) that heterogeneously expresses ALDH3A1.
Original language | English |
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Pages (from-to) | 302-306 |
Number of pages | 5 |
Journal | Bioconjugate Chemistry |
Volume | 28 |
Issue number | 2 |
DOIs | |
Publication status | Published - 15-02-2017 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biotechnology
- Bioengineering
- Biomedical Engineering
- Pharmacology
- Pharmaceutical Science
- Organic Chemistry