Development of pathological diagnosis support system using micro-computed tomography

Tomonari Hayakawa, Atsushi Teramoto, Yuka Kiriyama, Tetsuya Tsukamoto, Ayumi Yamada, Kuniaki Saito, Hiroshi Fujita

Research output: Contribution to journalArticlepeer-review

Abstract

In pathological diagnosis, the cutting position of pathological materials is subjectively deter-mined by pathologists. This leads to a low cutting accuracy, which in turn may lead to incorrect diagnoses. In this study, we developed a system that supports the determination of the cutting position by visualizing and analyzing the internal structure of pathological material using micro-computed tomography (CT) before cutting. This system consists of a dedicated micro-CT and cutting support software. The micro-CT system has a fixture for fixing the target, enabling the scanning of easily deformable pathological materials. In the cutting support software, a function that interactively selects the extraction plane while displaying the volume rendering image and outputs a pseudo-histological image was implemented. Our results confirmed that the pseudo-histological image showed the fine structure inside the organ and that the latter image was highly consistent with the pathological image.

Original languageEnglish
Pages (from-to)49-56
Number of pages8
JournalActa Histochemica et Cytochemica
Volume54
Issue number2
DOIs
Publication statusPublished - 2021

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Biochemistry
  • Physiology
  • Histology
  • Cell Biology

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