Diabetes with Preserved Renal Function Is an Independent Risk Factor for Renal Function Deterioration after Coronary Computed Tomography Angiography

Satoshi Isobe, Takashi Yamada, Kimihide Sato, Toshio Katagiri, Hisato Ohyama, Mutsuharu Hayashi, Daiji Yoshikawa, Hideki Ishii, Toyoaki Murohara

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

OBJECTIVES: Diabetes mellitus (DM) and high fasting glucose levels are reportedly risk factors for contrast-induced nephropathy after invasive coronary angiography in patients with renal dysfunction. Cystatin C (CyC) is a sensitive marker for detecting early impairment of renal function. Using CyC, we investigated whether DM would be a risk for worsening renal function after coronary computed tomography angiography (CCTA) in patients with preserved renal function. METHODS: Two hundred twenty-eight patients scheduled for CCTA were enrolled. The serum CyC at preprocedure and 1 day after procedure, urinary microalbumin at preprocedure, and oral fluid volume for 24 hours after procedure were measured. The percentage changes in CyC from preprocedure to 1 day after procedure (%CyC) were also calculated. RESULTS: Ninety-eight patients had DM. The %CyC and urinary microalbumin were significantly greater in DM patients than in non-DM patients. The percentage of patients showing a %CyC of 10% or greater was significantly greater in DM patients than in non-DM patients (27% vs 8%, P < 0.01). Using multivariate regression analysis, oral fluid volume and urinary microalbumin were independent predictors for a %CyC of 10% or greater in DM patients (β =-0.428 [P < 0.0001] and β = 0.464 [P < 0.0001], respectively). CONCLUSIONS: Diabetes mellitus is a risk factor for worsening changes in renal function after CCTA, even in patients with preserved renal function. In particular, elevated microalbuminuria and low oral fluid intake are high-risk factors for renal functional deterioration.

Original languageEnglish
Pages (from-to)750-754
Number of pages5
JournalJournal of Computer Assisted Tomography
Volume37
Issue number5
DOIs
Publication statusPublished - 01-09-2013

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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