Diacron reactive oxygen metabolites and biological antioxidant potential tests for patients with age-related macular degeneration

Toshiyuki Matsuura; Hiroki Kaneko; Kei Takayama; Rei Shibata; Keiko Kataoka; Seina Ito; Taichi Tsunekawa; Hideyuki Shimizu; Ayana Suzumura; Rina Namba; Yasuki Ito; Toyoaki Murohara; Hiroko Terasaki

doi:10.1186/s12886-020-01334-y

Diacron reactive oxygen metabolites and biological antioxidant potential tests for patients with age-related macular degeneration

Toshiyuki Matsuura, Hiroki Kaneko, Kei Takayama, Rei Shibata, Keiko Kataoka, Seina Ito, Taichi Tsunekawa, Hideyuki Shimizu, Ayana Suzumura, Rina Namba, Yasuki Ito, Toyoaki Murohara, Hiroko Terasaki

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Background: Previously, we showed that serum malondialdehyde (MDA) was significantly higher in patients with neovascular age-related macular degeneration (nAMD) than in those without AMD. The Diacron reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) tests are known markers of oxidative stress. The aim of this study was to use d-ROMs and BAP tests to evaluate changes in systemic oxidative stress in patients with nAMD. Methods: Blood serum samples were collected from 34 patients with nAMD (mean age: 76.5 ± 7.7 years; 22 men) and 20 control subjects (mean age: 62.9 ± 14.0 years; 10 men), and d-ROMs and BAP tests were examined. Results: In men, the mean level of d-ROMs for the nAMD patients was significantly higher than that for the controls (312.0 ± 52.4 vs. 275.1 ± 45.5 U.CARR, respectively; P <.05). There was a significant correlation between d-ROM level and CNV lesion area in the male nAMD group (r =.42, P =.05). There were no significant differences in mean BAP test results between the nAMD patients and controls for either sex (men: 2241 ± 549 vs. 2136 ± 246 μmol/L; women: 2263 ± 292 vs. 2335 ± 161 μmol/L). Conclusion: The d-ROMs test may provide a useful indicator of nAMD in men but not in women.

Original language	English
Article number	56
Journal	BMC Ophthalmology
Volume	20
Issue number	1
DOIs	https://doi.org/10.1186/s12886-020-01334-y
Publication status	Published - 18-02-2020
Externally published	Yes

All Science Journal Classification (ASJC) codes

Ophthalmology

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10.1186/s12886-020-01334-y

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Matsuura, T., Kaneko, H., Takayama, K., Shibata, R., Kataoka, K., Ito, S., Tsunekawa, T., Shimizu, H., Suzumura, A., Namba, R., Ito, Y., Murohara, T., & Terasaki, H. (2020). Diacron reactive oxygen metabolites and biological antioxidant potential tests for patients with age-related macular degeneration. BMC Ophthalmology, 20(1), Article 56. https://doi.org/10.1186/s12886-020-01334-y

@article{cf1493beced2440b9a3a7e968cd740b3,

title = "Diacron reactive oxygen metabolites and biological antioxidant potential tests for patients with age-related macular degeneration",

abstract = "Background: Previously, we showed that serum malondialdehyde (MDA) was significantly higher in patients with neovascular age-related macular degeneration (nAMD) than in those without AMD. The Diacron reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) tests are known markers of oxidative stress. The aim of this study was to use d-ROMs and BAP tests to evaluate changes in systemic oxidative stress in patients with nAMD. Methods: Blood serum samples were collected from 34 patients with nAMD (mean age: 76.5 ± 7.7 years; 22 men) and 20 control subjects (mean age: 62.9 ± 14.0 years; 10 men), and d-ROMs and BAP tests were examined. Results: In men, the mean level of d-ROMs for the nAMD patients was significantly higher than that for the controls (312.0 ± 52.4 vs. 275.1 ± 45.5 U.CARR, respectively; P <.05). There was a significant correlation between d-ROM level and CNV lesion area in the male nAMD group (r =.42, P =.05). There were no significant differences in mean BAP test results between the nAMD patients and controls for either sex (men: 2241 ± 549 vs. 2136 ± 246 μmol/L; women: 2263 ± 292 vs. 2335 ± 161 μmol/L). Conclusion: The d-ROMs test may provide a useful indicator of nAMD in men but not in women.",

author = "Toshiyuki Matsuura and Hiroki Kaneko and Kei Takayama and Rei Shibata and Keiko Kataoka and Seina Ito and Taichi Tsunekawa and Hideyuki Shimizu and Ayana Suzumura and Rina Namba and Yasuki Ito and Toyoaki Murohara and Hiroko Terasaki",

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year = "2020",

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doi = "10.1186/s12886-020-01334-y",

language = "English",

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Matsuura, T, Kaneko, H, Takayama, K, Shibata, R, Kataoka, K, Ito, S, Tsunekawa, T, Shimizu, H, Suzumura, A, Namba, R, Ito, Y, Murohara, T & Terasaki, H 2020, 'Diacron reactive oxygen metabolites and biological antioxidant potential tests for patients with age-related macular degeneration', BMC Ophthalmology, vol. 20, no. 1, 56. https://doi.org/10.1186/s12886-020-01334-y

TY - JOUR

T1 - Diacron reactive oxygen metabolites and biological antioxidant potential tests for patients with age-related macular degeneration

AU - Matsuura, Toshiyuki

AU - Kaneko, Hiroki

AU - Takayama, Kei

AU - Shibata, Rei

AU - Kataoka, Keiko

AU - Ito, Seina

AU - Tsunekawa, Taichi

AU - Shimizu, Hideyuki

AU - Suzumura, Ayana

AU - Namba, Rina

AU - Ito, Yasuki

AU - Murohara, Toyoaki

AU - Terasaki, Hiroko

PY - 2020/2/18

Y1 - 2020/2/18

N2 - Background: Previously, we showed that serum malondialdehyde (MDA) was significantly higher in patients with neovascular age-related macular degeneration (nAMD) than in those without AMD. The Diacron reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) tests are known markers of oxidative stress. The aim of this study was to use d-ROMs and BAP tests to evaluate changes in systemic oxidative stress in patients with nAMD. Methods: Blood serum samples were collected from 34 patients with nAMD (mean age: 76.5 ± 7.7 years; 22 men) and 20 control subjects (mean age: 62.9 ± 14.0 years; 10 men), and d-ROMs and BAP tests were examined. Results: In men, the mean level of d-ROMs for the nAMD patients was significantly higher than that for the controls (312.0 ± 52.4 vs. 275.1 ± 45.5 U.CARR, respectively; P <.05). There was a significant correlation between d-ROM level and CNV lesion area in the male nAMD group (r =.42, P =.05). There were no significant differences in mean BAP test results between the nAMD patients and controls for either sex (men: 2241 ± 549 vs. 2136 ± 246 μmol/L; women: 2263 ± 292 vs. 2335 ± 161 μmol/L). Conclusion: The d-ROMs test may provide a useful indicator of nAMD in men but not in women.

AB - Background: Previously, we showed that serum malondialdehyde (MDA) was significantly higher in patients with neovascular age-related macular degeneration (nAMD) than in those without AMD. The Diacron reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) tests are known markers of oxidative stress. The aim of this study was to use d-ROMs and BAP tests to evaluate changes in systemic oxidative stress in patients with nAMD. Methods: Blood serum samples were collected from 34 patients with nAMD (mean age: 76.5 ± 7.7 years; 22 men) and 20 control subjects (mean age: 62.9 ± 14.0 years; 10 men), and d-ROMs and BAP tests were examined. Results: In men, the mean level of d-ROMs for the nAMD patients was significantly higher than that for the controls (312.0 ± 52.4 vs. 275.1 ± 45.5 U.CARR, respectively; P <.05). There was a significant correlation between d-ROM level and CNV lesion area in the male nAMD group (r =.42, P =.05). There were no significant differences in mean BAP test results between the nAMD patients and controls for either sex (men: 2241 ± 549 vs. 2136 ± 246 μmol/L; women: 2263 ± 292 vs. 2335 ± 161 μmol/L). Conclusion: The d-ROMs test may provide a useful indicator of nAMD in men but not in women.

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U2 - 10.1186/s12886-020-01334-y

DO - 10.1186/s12886-020-01334-y

M3 - Article

C2 - 32070305

AN - SCOPUS:85079652634

SN - 1471-2415

VL - 20

JO - BMC Ophthalmology

JF - BMC Ophthalmology

IS - 1

M1 - 56

ER -

Diacron reactive oxygen metabolites and biological antioxidant potential tests for patients with age-related macular degeneration

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