Diagnosis and management of bone fragility in diabetes: an emerging challenge

on behalf of the Bone and Diabetes Working Group of IOF

doi:10.1007/s00198-018-4650-2

Diagnosis and management of bone fragility in diabetes: an emerging challenge

on behalf of the Bone and Diabetes Working Group of IOF

Department of Endocrinology, Diabetes and Metabolism

Research output: Contribution to journal › Review article › peer-review

253 Citations (Scopus)

Abstract

Fragility fractures are increasingly recognized as a complication of both type 1 and type 2 diabetes, with fracture risk that increases with disease duration and poor glycemic control. Yet the identification and management of fracture risk in these patients remains challenging. This review explores the clinical characteristics of bone fragility in adults with diabetes and highlights recent studies that have evaluated bone mineral density (BMD), bone microstructure and material properties, biochemical markers, and fracture prediction algorithms (i.e., FRAX) in these patients. It further reviews the impact of diabetes drugs on bone as well as the efficacy of osteoporosis treatments in this population. We finally propose an algorithm for the identification and management of diabetic patients at increased fracture risk.

Original language	English
Pages (from-to)	2585-2596
Number of pages	12
Journal	Osteoporosis International
Volume	29
Issue number	12
DOIs	https://doi.org/10.1007/s00198-018-4650-2
Publication status	Published - 01-12-2018

All Science Journal Classification (ASJC) codes

Endocrinology, Diabetes and Metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s00198-018-4650-2

Cite this

@article{64f4b942acdd4f8e89aed4b3535ffe15,

title = "Diagnosis and management of bone fragility in diabetes: an emerging challenge",

abstract = "Fragility fractures are increasingly recognized as a complication of both type 1 and type 2 diabetes, with fracture risk that increases with disease duration and poor glycemic control. Yet the identification and management of fracture risk in these patients remains challenging. This review explores the clinical characteristics of bone fragility in adults with diabetes and highlights recent studies that have evaluated bone mineral density (BMD), bone microstructure and material properties, biochemical markers, and fracture prediction algorithms (i.e., FRAX) in these patients. It further reviews the impact of diabetes drugs on bone as well as the efficacy of osteoporosis treatments in this population. We finally propose an algorithm for the identification and management of diabetic patients at increased fracture risk.",

keywords = "Diabetes, Diabetes-related bone disease, Fracture, Osteoporosis",

author = "{on behalf of the Bone and Diabetes Working Group of IOF} and Ferrari, {S. L.} and B. Abrahamsen and N. Napoli and K. Akesson and M. Chandran and R. Eastell and {El-Hajj Fuleihan}, G. and R. Josse and Kendler, {D. L.} and M. Kraenzlin and A. Suzuki and Pierroz, {D. D.} and Schwartz, {A. V.} and Leslie, {W. D.} and Ferrari, {S. L.} and Ardawi, {M. S.M.} and C. Cooper and A. Mithal",

note = "Publisher Copyright: {\textcopyright} 2018, The Author(s).",

year = "2018",

month = dec,

day = "1",

doi = "10.1007/s00198-018-4650-2",

language = "English",

volume = "29",

pages = "2585--2596",

journal = "Osteoporosis International",

issn = "0937-941X",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "12",

}

TY - JOUR

T1 - Diagnosis and management of bone fragility in diabetes

T2 - an emerging challenge

AU - on behalf of the Bone and Diabetes Working Group of IOF

AU - Ferrari, S. L.

AU - Abrahamsen, B.

AU - Napoli, N.

AU - Akesson, K.

AU - Chandran, M.

AU - Eastell, R.

AU - El-Hajj Fuleihan, G.

AU - Josse, R.

AU - Kendler, D. L.

AU - Kraenzlin, M.

AU - Suzuki, A.

AU - Pierroz, D. D.

AU - Schwartz, A. V.

AU - Leslie, W. D.

AU - Ferrari, S. L.

AU - Ardawi, M. S.M.

AU - Cooper, C.

AU - Mithal, A.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Fragility fractures are increasingly recognized as a complication of both type 1 and type 2 diabetes, with fracture risk that increases with disease duration and poor glycemic control. Yet the identification and management of fracture risk in these patients remains challenging. This review explores the clinical characteristics of bone fragility in adults with diabetes and highlights recent studies that have evaluated bone mineral density (BMD), bone microstructure and material properties, biochemical markers, and fracture prediction algorithms (i.e., FRAX) in these patients. It further reviews the impact of diabetes drugs on bone as well as the efficacy of osteoporosis treatments in this population. We finally propose an algorithm for the identification and management of diabetic patients at increased fracture risk.

AB - Fragility fractures are increasingly recognized as a complication of both type 1 and type 2 diabetes, with fracture risk that increases with disease duration and poor glycemic control. Yet the identification and management of fracture risk in these patients remains challenging. This review explores the clinical characteristics of bone fragility in adults with diabetes and highlights recent studies that have evaluated bone mineral density (BMD), bone microstructure and material properties, biochemical markers, and fracture prediction algorithms (i.e., FRAX) in these patients. It further reviews the impact of diabetes drugs on bone as well as the efficacy of osteoporosis treatments in this population. We finally propose an algorithm for the identification and management of diabetic patients at increased fracture risk.

KW - Diabetes

KW - Diabetes-related bone disease

KW - Fracture

KW - Osteoporosis

UR - http://www.scopus.com/inward/record.url?scp=85051441673&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85051441673&partnerID=8YFLogxK

U2 - 10.1007/s00198-018-4650-2

DO - 10.1007/s00198-018-4650-2

M3 - Review article

C2 - 30066131

AN - SCOPUS:85051441673

SN - 0937-941X

VL - 29

SP - 2585

EP - 2596

JO - Osteoporosis International

JF - Osteoporosis International

IS - 12

ER -

Diagnosis and management of bone fragility in diabetes: an emerging challenge

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this