Diagnosis and management of bone fragility in diabetes

an emerging challenge

on behalf of the Bone and Diabetes Working Group of IOF

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Fragility fractures are increasingly recognized as a complication of both type 1 and type 2 diabetes, with fracture risk that increases with disease duration and poor glycemic control. Yet the identification and management of fracture risk in these patients remains challenging. This review explores the clinical characteristics of bone fragility in adults with diabetes and highlights recent studies that have evaluated bone mineral density (BMD), bone microstructure and material properties, biochemical markers, and fracture prediction algorithms (i.e., FRAX) in these patients. It further reviews the impact of diabetes drugs on bone as well as the efficacy of osteoporosis treatments in this population. We finally propose an algorithm for the identification and management of diabetic patients at increased fracture risk.

Original languageEnglish
Pages (from-to)2585-2596
Number of pages12
JournalOsteoporosis International
Volume29
Issue number12
DOIs
Publication statusPublished - 01-12-2018

Fingerprint

Bone and Bones
Risk Management
Type 1 Diabetes Mellitus
Bone Density
Type 2 Diabetes Mellitus
Osteoporosis
Biomarkers
Pharmaceutical Preparations
Population

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism

Cite this

on behalf of the Bone and Diabetes Working Group of IOF. / Diagnosis and management of bone fragility in diabetes : an emerging challenge. In: Osteoporosis International. 2018 ; Vol. 29, No. 12. pp. 2585-2596.
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on behalf of the Bone and Diabetes Working Group of IOF 2018, 'Diagnosis and management of bone fragility in diabetes: an emerging challenge', Osteoporosis International, vol. 29, no. 12, pp. 2585-2596. https://doi.org/10.1007/s00198-018-4650-2

Diagnosis and management of bone fragility in diabetes : an emerging challenge. / on behalf of the Bone and Diabetes Working Group of IOF.

In: Osteoporosis International, Vol. 29, No. 12, 01.12.2018, p. 2585-2596.

Research output: Contribution to journalReview article

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T1 - Diagnosis and management of bone fragility in diabetes

T2 - an emerging challenge

AU - on behalf of the Bone and Diabetes Working Group of IOF

AU - Ferrari, S. L.

AU - Abrahamsen, B.

AU - Napoli, N.

AU - Akesson, K.

AU - Chandran, M.

AU - Eastell, R.

AU - El-Hajj Fuleihan, G.

AU - Josse, R.

AU - Kendler, D. L.

AU - Kraenzlin, M.

AU - Suzuki, A.

AU - Pierroz, D. D.

AU - Schwartz, A. V.

AU - Leslie, W. D.

AU - Ferrari, S. L.

AU - Ardawi, M. S.M.

AU - Suzuki, Atsushi

AU - Mithal, A.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Fragility fractures are increasingly recognized as a complication of both type 1 and type 2 diabetes, with fracture risk that increases with disease duration and poor glycemic control. Yet the identification and management of fracture risk in these patients remains challenging. This review explores the clinical characteristics of bone fragility in adults with diabetes and highlights recent studies that have evaluated bone mineral density (BMD), bone microstructure and material properties, biochemical markers, and fracture prediction algorithms (i.e., FRAX) in these patients. It further reviews the impact of diabetes drugs on bone as well as the efficacy of osteoporosis treatments in this population. We finally propose an algorithm for the identification and management of diabetic patients at increased fracture risk.

AB - Fragility fractures are increasingly recognized as a complication of both type 1 and type 2 diabetes, with fracture risk that increases with disease duration and poor glycemic control. Yet the identification and management of fracture risk in these patients remains challenging. This review explores the clinical characteristics of bone fragility in adults with diabetes and highlights recent studies that have evaluated bone mineral density (BMD), bone microstructure and material properties, biochemical markers, and fracture prediction algorithms (i.e., FRAX) in these patients. It further reviews the impact of diabetes drugs on bone as well as the efficacy of osteoporosis treatments in this population. We finally propose an algorithm for the identification and management of diabetic patients at increased fracture risk.

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