Diagnostic and prognostic value of immunohistochemical expression of S100P and IMP3 in transpapillary biliary forceps biopsy samples of extrahepatic bile duct carcinoma.

Hiroki Kawashima, Akihiro Itoh, Eizaburo Ohno, Ryoji Miyahara, Naoki Ohmiya, Tsutomu Tanaka, Yoshie Shimoyama, Shigeo Nakamura, Tomoki Ebata, Masato Nagino, Hidemi Goto, Yoshiki Hirooka

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Because the biopsy specimen of extrahepatic bile duct carcinoma (EHBDC) is small and shows reactive changes, the histological distinction between malignant and benign tissue can be difficult. Recent studies reported that S100P and insulin-like growth factor II mRNA-binding protein 3 (IMP3) were not only diagnostic molecules but also prognostic biomarkers in several organs. The objective of this study is to clarify the diagnostic and prognostic value of immunohistochemical expression of S100P and IMP3 in transpapillary biliary forceps biopsy (TBFB) samples. The TBFB samples were collected from 80 patients (EHBDC, 68 patients; benign, 12 patients), retrospectively. When using cytoplasmic-positive staining for IMP3 as a marker of malignancy, the sensitivity and specificity reached 79.4 and 91.7 %, respectively. The sensitivity, specificity and accuracy achieved 89.7, 91.7 and 90.0 %, respectively, when using positive staining for IMP3 and/or positive histology as a maker of malignancy. While univariate (P = 0.033) and multivariate (P = 0.039) analysis revealed that S100P-positive EHBDC patients showed significantly shorter survival. The results of this study suggest that immunohistochemical staining for IMP3 is useful in the diagnosis of EHBDC and that of S100P is useful as a prognostic marker for EHBDC.

Original languageEnglish
Pages (from-to)441-447
Number of pages7
JournalUnknown Journal
Volume20
Issue number4
DOIs
Publication statusPublished - 04-2013

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Fingerprint Dive into the research topics of 'Diagnostic and prognostic value of immunohistochemical expression of S100P and IMP3 in transpapillary biliary forceps biopsy samples of extrahepatic bile duct carcinoma.'. Together they form a unique fingerprint.

  • Cite this