TY - JOUR
T1 - Diagnostic performance of different imaging modalities in the assessment of distant metastasis and local recurrence of tumor in patients with non-small cell lung cancer
AU - Ohno, Yoshiharu
AU - Yoshikawa, Takeshi
AU - Kishida, Yuji
AU - Seki, Shinichiro
AU - Koyama, Hisanobu
AU - Yui, Masao
AU - Kassai, Yoshimori
AU - Aoyagi, Kota
AU - Kaminaga, Shigeo
AU - Sugimura, Kazuro
N1 - Funding Information:
Contract grant sponsor: Toshiba Medical Systems Corporation; Contract grant sponsor: Bayer Pharma; Contract grant sponsor: Eizai, Co., Ltd. The authors thank Daisuke Hokka, MD, PhD, Yugo Tana-ka, MD, PhD, Yoshimasa Maniwa, MD, PhD (Division of Cardiovascular, Thoracic and Pediatric Surgery, Department of Surgery, Kobe University Graduate School of Medicine), Motoko Tachihara, MD, Daisuke Tamura, MD, PhD, Kazuyuki Kobayashi, MD, PhD, Yoshihiro Nishimura, MD, PhD (Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine), Yasuhiro Sakai, MD, PhD, Tomoo Ito, MD, PhD (Department of Diagnostic Pathology, Kobe University Hospital), and Katsusuke Kyotani, RT (Center for Radiology and Radiation Oncology, Kobe University Hospital) for valuable contributions to the study.
Funding Information:
This prospective study was approved by the Institutional Review Board of Kobe University Hospital, and written informed consent was obtained from all patients. This work was financially and/or technically supported by Toshiba Medical Systems, Bayer Pharma, and Eizai. Four of the authors (Y.M., Y.K., K.A., and S.K.) are employees of Toshiba Medical Systems, but did not have any say over any of the data and information submitted for publication or which data and information were to be included in this study. Four of the authors (Y.M., Y.K., K.A., and S.K.) were technically supported by the sequence and software issues in this study.
Publisher Copyright:
© 2017 Wiley Periodicals, Inc.
PY - 2017/12
Y1 - 2017/12
N2 - Purpose: To compare the diagnostic performance of positron emission tomography with [18F] fluoro-2-deoxy-glucose (FDG-PET) coregistered with magnetic resonance imaging (FDG-PET/MRI), MRI with and without diffusion-weighted imaging (DWI), FDG-PET fused with computed tomography (FDG-PET/CT) with brain contrast-enhanced (CE-) MRI, and routine radiological examination for assessment of postoperative recurrence in nonsmall-cell lung cancer (NSCLC) patients. Materials and Methods: 96 consecutive postoperative NSCLC patients (52 men, 44 women; mean age 72 years) prospectively underwent whole-body 3T MRI with and without DWI; PET/CTs and routine radiological examinations consisted of CE-brain MRI, whole-body CE-CT, and bone scintigraphy. The patients were divided into a recurrence (n = 17) and a nonrecurrence (n = 79) group based on pathological and follow-up examinations. All coregistered PET/MRIs were generated by proprietary software. The probability of recurrence was visually assessed on a per-patient basis. Receiver operating characteristic analyses were used to compare the diagnostic performance of all methods. Finally, diagnostic capabilities were compared by means of McNemar's test. Results: Areas under the curves (Azs) were significantly larger for PET/MRI and whole-body MRI with DWI (Az = 0.99) than for PET/CT (Az = 0.92, P < 0.05) and conventional radiological examination (Az = 0.91, P < 0.05). Specificity and accuracy of PET/MRI and MRI with and without DWI were significantly higher than those of PET/CT (P < 0.05) and routine radiological examination (P < 0.05). Conclusion: Whole-body FDG-PET/MRI and MRI with DWI were found to be more specific and accurate than FDG-PET/CT and routine radiological examinations for assessment of recurrence in NSCLC patients, although MRI with and without DWI demonstrated slightly lower sensitivity than PET/CT. Level of Evidence: 2. Technical Efficacy: Stage 2. J. Magn. Reson. Imaging 2017;46:1707–1717.
AB - Purpose: To compare the diagnostic performance of positron emission tomography with [18F] fluoro-2-deoxy-glucose (FDG-PET) coregistered with magnetic resonance imaging (FDG-PET/MRI), MRI with and without diffusion-weighted imaging (DWI), FDG-PET fused with computed tomography (FDG-PET/CT) with brain contrast-enhanced (CE-) MRI, and routine radiological examination for assessment of postoperative recurrence in nonsmall-cell lung cancer (NSCLC) patients. Materials and Methods: 96 consecutive postoperative NSCLC patients (52 men, 44 women; mean age 72 years) prospectively underwent whole-body 3T MRI with and without DWI; PET/CTs and routine radiological examinations consisted of CE-brain MRI, whole-body CE-CT, and bone scintigraphy. The patients were divided into a recurrence (n = 17) and a nonrecurrence (n = 79) group based on pathological and follow-up examinations. All coregistered PET/MRIs were generated by proprietary software. The probability of recurrence was visually assessed on a per-patient basis. Receiver operating characteristic analyses were used to compare the diagnostic performance of all methods. Finally, diagnostic capabilities were compared by means of McNemar's test. Results: Areas under the curves (Azs) were significantly larger for PET/MRI and whole-body MRI with DWI (Az = 0.99) than for PET/CT (Az = 0.92, P < 0.05) and conventional radiological examination (Az = 0.91, P < 0.05). Specificity and accuracy of PET/MRI and MRI with and without DWI were significantly higher than those of PET/CT (P < 0.05) and routine radiological examination (P < 0.05). Conclusion: Whole-body FDG-PET/MRI and MRI with DWI were found to be more specific and accurate than FDG-PET/CT and routine radiological examinations for assessment of recurrence in NSCLC patients, although MRI with and without DWI demonstrated slightly lower sensitivity than PET/CT. Level of Evidence: 2. Technical Efficacy: Stage 2. J. Magn. Reson. Imaging 2017;46:1707–1717.
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U2 - 10.1002/jmri.25726
DO - 10.1002/jmri.25726
M3 - Article
C2 - 28419645
AN - SCOPUS:85018605823
VL - 46
SP - 1707
EP - 1717
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
SN - 1053-1807
IS - 6
ER -