Diagnostic performance of real-time tissue elastography in chronic hepatitis C patients with sustained virological response

Yoshihiko Tachi, Takanori Hirai, Yuko Kojima, Haruhiko Tachino, Chikao Hosokawa, Takahiro Ohya, Yuji Yasue, Yuta Kurokawa, Yoshinori Torii, Satoshi Yamamoto, Hironao Matsuura, Takashi Kobayashi, Hironao Miyoshi, Kazuo Inui, Yoshiaki Katano

Research output: Contribution to journalArticlepeer-review

Abstract

Background and aims: Real-time tissue elastography is a non-invasive method for measuring liver elasticity. However, there are no reports evaluating the value of real-time tissue elastography for liver fibrosis in hepatitis C virus-infected patients with sustained virological response. The aim of this study is to clarify the diagnostic performance of real-time tissue elastography in patients with sustained virological response. Methods: In this prospective study, we enrolled 425 chronic hepatitis C patients who underwent liver biopsy: 118 patients with sustained virological response (45.8% women) and 307 patients with hepatitis C virus (51.1% women). The post-sustained virological response biopsy was performed 5.9 ± 1.8 years after the therapy. Liver fibrosis index measurements as assessed using real-time tissue elastography were performed on the same day of biopsy. Results: The respective mean liver fibrosis index values for fibrosis stages F0, F1, F2, F3, and F4 were 2.82 ± 0.33, 2.90 ± 0.51, 3.06 ± 0.58, 3.65 ± 0.24, and 3.83 ± 0.65, respectively, in patients with sustained virological response. The diagnostic accuracies expressed as areas under the receiver operating characteristic curves in patients with sustained virological response were 0.776 for the diagnosis of significant fibrosis (≥F2), 0.885 for severe fibrosis (≥F3), and 0.860 for cirrhosis (F4), respectively. The optimum cut-off values liver fibrosis index were 3.14 for ≥F2, 3.24 for ≥F3, and 3.30 for F4 in patients with sustained virological response. Conclusion: Real-time tissue elastography is an acceptable method for predicting the severity of fibrosis in hepatitis C virus patients with sustained virological response.

Original languageEnglish
Pages (from-to)609-615
Number of pages7
JournalEuropean Journal of Gastroenterology and Hepatology
Volume32
Issue number5
DOIs
Publication statusPublished - 01-05-2020

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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