Diagnostic performance of the simultaneous acquisition rest 99 mTc-tetrofosmin/stress201Tl dual-isotope protocol with a semiconductor camera: Comparison with the rest-stress 99 mTc-tetrofosmin protocol

Itta Kawamura, Ryo Kajiura, Yusuke Motoji, Syuichi Okamoto, Toru Tanigaki, Hiroyuki Omori, Tetsuo Hirata, Jun Kikuchi, Hideaki Ota, Yoshihiro Sobue, Taiji Miyake, Tomohiro Tsunekawa, Takayoshi Kato, Yoshiaki Kawase, Munenori Okubo, Hiroki Kamiya, Kunihiko Tsuchiya, Shinji Tomita, Akihiro Hirakawa, Takeshi KondoTakahiko Suzuki, Hitoshi Matsuo

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Background: This study compared the diagnostic value of myocardial perfusion imaging (MPI) between the rest-stress99 m Tc-tetrofosmin protocol (Tc/Tc protocol) and simultaneous acquisition rest99 mTc-tetrofosmin/stress201Tl dual-isotope protocol (SDI protocol) with a semiconductor camera. Methods and Results: We retrospectively studied 147 patients who underwent stress MPI using a cadmium-zinc-telluride camera and invasive coronary angiography within a 3-month interval. The Tc/Tc and SDI protocols were used in 59 and 88 patients, respectively. The sensitivity, specificity, and accuracy of the summed difference score in per-patient analysis were 56%, 85%, and 69%, respectively, for the Tc/Tc protocol and 89%, 82%, and 85%, respectively, for the SDI protocol. The area under the receiver operating characteristic curve was significantly better for the SDI than Tc/Tc protocol for the left anterior descending artery (0.836 vs. 0.674; P=0.0380), the left circumflex artery (0.754 vs. 0.599; P=0.0441), and in per-patient analysis (0.875 vs. 0.707; P=0.0135). There was no significant difference in the diagnostic accuracy of the summed stress score for any vessel or in per-patient analysis between the 2 protocols. Conclusions: The SDI protocol had a higher diagnostic accuracy for the detection of coronary ischemia than the Tc/Tc protocol.

Original languageEnglish
Pages (from-to)2837-2844
Number of pages8
JournalCirculation Journal
Issue number11
Publication statusPublished - 2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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