TY - JOUR
T1 - Diagnostic value of intestinal fatty acid-binding protein for pneumatosis intestinalis
AU - Matsumoto, Shokei
AU - Sekine, Kazuhiko
AU - Funaoka, Hiroyuki
AU - Funabiki, Tomohiro
AU - Yamazaki, Motoyasu
AU - Orita, Tomohiko
AU - Hayashida, Kei
AU - Kitano, Mitsuhide
N1 - Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Background Pneumatosis intestinalis (PI) is known as a sign of a life-threatening bowel ischemia. We aimed to evaluate the utility of intestinal fatty acid-binding protein (I-FABP) in the diagnosis of pathologic PI. Methods All consecutive patients who presented to our emergency department with PI were prospectively enrolled. The diagnostic performance of I-FABP for pathologic PI was compared with that of other traditional biomarkers and various parameters. Results Seventy patients with PI were enrolled. Pathologic PI was diagnosed in 27 patients (39%). The levels of most biomarkers were significantly higher in patients with pathologic PI than those with nonpathologic PI (P <.05). Receiver operator characteristic analysis revealed that the area under the curve (AUC) was highest for I-FABP (area under the curve =.82) in the diagnosis of pathologic PI. Conclusions High I-FABP value, in combination with other parameters, might be clinically useful for pathologic PI.
AB - Background Pneumatosis intestinalis (PI) is known as a sign of a life-threatening bowel ischemia. We aimed to evaluate the utility of intestinal fatty acid-binding protein (I-FABP) in the diagnosis of pathologic PI. Methods All consecutive patients who presented to our emergency department with PI were prospectively enrolled. The diagnostic performance of I-FABP for pathologic PI was compared with that of other traditional biomarkers and various parameters. Results Seventy patients with PI were enrolled. Pathologic PI was diagnosed in 27 patients (39%). The levels of most biomarkers were significantly higher in patients with pathologic PI than those with nonpathologic PI (P <.05). Receiver operator characteristic analysis revealed that the area under the curve (AUC) was highest for I-FABP (area under the curve =.82) in the diagnosis of pathologic PI. Conclusions High I-FABP value, in combination with other parameters, might be clinically useful for pathologic PI.
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U2 - 10.1016/j.amjsurg.2016.04.002
DO - 10.1016/j.amjsurg.2016.04.002
M3 - Article
C2 - 27401839
AN - SCOPUS:84992642875
SN - 0002-9610
VL - 212
SP - 961
EP - 968
JO - American Journal of Surgery
JF - American Journal of Surgery
IS - 5
ER -