Diazepam reduces both arterial blood pressure and muscle sympathetic nerve activity in human

Tsuyoshi Kitajima, Takashi Kanbayashi, Yasushi Saito, Yuji Takahashi, Yuriko Ogawa, Tomonari Sugiyama, Yoshihiko Kaneko, Rika Aizawa, Tetsuo Shimizu

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

It is known that benzodiazepines have a hypotensive effect, but the mechanism has not been well elucidated yet. To clarify whether this effect is due to central or peripheral mechanism, we administered 5 mg of diazepam or saline intravenously to healthy volunteers and assessed the change in blood pressure, heart rate, muscle sympathetic nerve activity and heart rate variability. After diazepam administration, systolic and mean blood pressure decreased significantly. Muscle sympathetic nerve activity was also significantly reduced but heart rate did not change, whereas the variables of spectral analysis of heart rate variability did not show significant change. We concluded that the hypotensive effect of diazepam in human is mainly due to the central mechanism.

Original languageEnglish
Pages (from-to)77-80
Number of pages4
JournalNeuroscience Letters
Volume355
Issue number1-2
DOIs
Publication statusPublished - 23-01-2004

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Diazepam
Human Activities
Arterial Pressure
Heart Rate
Muscles
Blood Pressure
Benzodiazepines
Myocardium
Healthy Volunteers

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Kitajima, T., Kanbayashi, T., Saito, Y., Takahashi, Y., Ogawa, Y., Sugiyama, T., ... Shimizu, T. (2004). Diazepam reduces both arterial blood pressure and muscle sympathetic nerve activity in human. Neuroscience Letters, 355(1-2), 77-80. https://doi.org/10.1016/j.neulet.2003.10.054
Kitajima, Tsuyoshi ; Kanbayashi, Takashi ; Saito, Yasushi ; Takahashi, Yuji ; Ogawa, Yuriko ; Sugiyama, Tomonari ; Kaneko, Yoshihiko ; Aizawa, Rika ; Shimizu, Tetsuo. / Diazepam reduces both arterial blood pressure and muscle sympathetic nerve activity in human. In: Neuroscience Letters. 2004 ; Vol. 355, No. 1-2. pp. 77-80.
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Kitajima, T, Kanbayashi, T, Saito, Y, Takahashi, Y, Ogawa, Y, Sugiyama, T, Kaneko, Y, Aizawa, R & Shimizu, T 2004, 'Diazepam reduces both arterial blood pressure and muscle sympathetic nerve activity in human', Neuroscience Letters, vol. 355, no. 1-2, pp. 77-80. https://doi.org/10.1016/j.neulet.2003.10.054

Diazepam reduces both arterial blood pressure and muscle sympathetic nerve activity in human. / Kitajima, Tsuyoshi; Kanbayashi, Takashi; Saito, Yasushi; Takahashi, Yuji; Ogawa, Yuriko; Sugiyama, Tomonari; Kaneko, Yoshihiko; Aizawa, Rika; Shimizu, Tetsuo.

In: Neuroscience Letters, Vol. 355, No. 1-2, 23.01.2004, p. 77-80.

Research output: Contribution to journalArticle

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AU - Sugiyama, Tomonari

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AU - Shimizu, Tetsuo

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