Diazepam reduces both arterial blood pressure and muscle sympathetic nerve activity in human

Tsuyoshi Kitajima, Takashi Kanbayashi, Yasushi Saito, Yuji Takahashi, Yuriko Ogawa, Tomonari Sugiyama, Yoshihiko Kaneko, Rika Aizawa, Tetsuo Shimizu

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24 Citations (Scopus)

Abstract

It is known that benzodiazepines have a hypotensive effect, but the mechanism has not been well elucidated yet. To clarify whether this effect is due to central or peripheral mechanism, we administered 5 mg of diazepam or saline intravenously to healthy volunteers and assessed the change in blood pressure, heart rate, muscle sympathetic nerve activity and heart rate variability. After diazepam administration, systolic and mean blood pressure decreased significantly. Muscle sympathetic nerve activity was also significantly reduced but heart rate did not change, whereas the variables of spectral analysis of heart rate variability did not show significant change. We concluded that the hypotensive effect of diazepam in human is mainly due to the central mechanism.

Original languageEnglish
Pages (from-to)77-80
Number of pages4
JournalNeuroscience Letters
Volume355
Issue number1-2
DOIs
Publication statusPublished - 23-01-2004

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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    Kitajima, T., Kanbayashi, T., Saito, Y., Takahashi, Y., Ogawa, Y., Sugiyama, T., Kaneko, Y., Aizawa, R., & Shimizu, T. (2004). Diazepam reduces both arterial blood pressure and muscle sympathetic nerve activity in human. Neuroscience Letters, 355(1-2), 77-80. https://doi.org/10.1016/j.neulet.2003.10.054