Diet and colorectal cancer mortality

Results from the Japan collaborative cohort study

Masayo Kojima, Kenji Wakai, Koji Tamakoshi, Shinkan Tokudome, Hideaki Toyoshima, Yoshiyuki Watanabe, Norihiko Hayakawa, Koji Suzuki, Shuji Hashimoto, Yoshinori Ito, Akiko Tamakoshi

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

The relationship between diet and colorectal cancer mortality was analyzed in a prospective study of 45,181 men and 62,643 women aged 40-79 yr enrolled in the Japan Collaborative Cohort Study. Between 1988 and 1990, subjects completed a self-administered questionnaire on their sociodemographic characteristics, diet, and other lifestyle habits. During the follow-up period (average 9.9 yr), 284 colon cancer deaths (138 men and 146 women) and 173 rectal cancer deaths (116 men and 57 women) were confirmed. The only significant association of colorectal cancer mortality with vegetable intake was observed between male rectal cancer mortality and green leafy vegetable consumption [hazard ratio (HR) using Cox proportional hazard models = 0.6; 95% confidence interval (CI) = 0.3-0.9; P for trend = 0.02]. Yogurt intake was also inversely associated with male rectal cancer mortality (HR = 0.5; 95% CI = 0.2-1.0; P for trend = 0.04). Egg consumption was positively associated with male colon cancer mortality (P for trend = 0.04). Women with high fruit consumption had increased colon cancer mortality (HR = 1.6; 95% CI = 1.0-2.6; P for trend = 0.04). It should be noted that this study lacked statistical power due to small sample size and measurement error in the food-frequency questionnaire. Further investigation is therefore necessary to confirm the association between diet and colorectal cancer, especially by subsites and gender.

Original languageEnglish
Pages (from-to)23-32
Number of pages10
JournalNutrition and Cancer
Volume50
Issue number1
DOIs
Publication statusPublished - 01-01-2004

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Colorectal Neoplasms
Japan
Cohort Studies
Diet
Mortality
Rectal Neoplasms
Colonic Neoplasms
Confidence Intervals
Vegetables
Yogurt
Proportional Hazards Models
Sample Size
Habits
Ovum
Life Style
Fruit
Prospective Studies
Food
Surveys and Questionnaires

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Oncology
  • Nutrition and Dietetics
  • Cancer Research

Cite this

Kojima, M., Wakai, K., Tamakoshi, K., Tokudome, S., Toyoshima, H., Watanabe, Y., ... Tamakoshi, A. (2004). Diet and colorectal cancer mortality: Results from the Japan collaborative cohort study. Nutrition and Cancer, 50(1), 23-32. https://doi.org/10.1207/s15327914nc5001_4
Kojima, Masayo ; Wakai, Kenji ; Tamakoshi, Koji ; Tokudome, Shinkan ; Toyoshima, Hideaki ; Watanabe, Yoshiyuki ; Hayakawa, Norihiko ; Suzuki, Koji ; Hashimoto, Shuji ; Ito, Yoshinori ; Tamakoshi, Akiko. / Diet and colorectal cancer mortality : Results from the Japan collaborative cohort study. In: Nutrition and Cancer. 2004 ; Vol. 50, No. 1. pp. 23-32.
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Kojima, M, Wakai, K, Tamakoshi, K, Tokudome, S, Toyoshima, H, Watanabe, Y, Hayakawa, N, Suzuki, K, Hashimoto, S, Ito, Y & Tamakoshi, A 2004, 'Diet and colorectal cancer mortality: Results from the Japan collaborative cohort study', Nutrition and Cancer, vol. 50, no. 1, pp. 23-32. https://doi.org/10.1207/s15327914nc5001_4

Diet and colorectal cancer mortality : Results from the Japan collaborative cohort study. / Kojima, Masayo; Wakai, Kenji; Tamakoshi, Koji; Tokudome, Shinkan; Toyoshima, Hideaki; Watanabe, Yoshiyuki; Hayakawa, Norihiko; Suzuki, Koji; Hashimoto, Shuji; Ito, Yoshinori; Tamakoshi, Akiko.

In: Nutrition and Cancer, Vol. 50, No. 1, 01.01.2004, p. 23-32.

Research output: Contribution to journalArticle

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AU - Kojima, Masayo

AU - Wakai, Kenji

AU - Tamakoshi, Koji

AU - Tokudome, Shinkan

AU - Toyoshima, Hideaki

AU - Watanabe, Yoshiyuki

AU - Hayakawa, Norihiko

AU - Suzuki, Koji

AU - Hashimoto, Shuji

AU - Ito, Yoshinori

AU - Tamakoshi, Akiko

PY - 2004/1/1

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N2 - The relationship between diet and colorectal cancer mortality was analyzed in a prospective study of 45,181 men and 62,643 women aged 40-79 yr enrolled in the Japan Collaborative Cohort Study. Between 1988 and 1990, subjects completed a self-administered questionnaire on their sociodemographic characteristics, diet, and other lifestyle habits. During the follow-up period (average 9.9 yr), 284 colon cancer deaths (138 men and 146 women) and 173 rectal cancer deaths (116 men and 57 women) were confirmed. The only significant association of colorectal cancer mortality with vegetable intake was observed between male rectal cancer mortality and green leafy vegetable consumption [hazard ratio (HR) using Cox proportional hazard models = 0.6; 95% confidence interval (CI) = 0.3-0.9; P for trend = 0.02]. Yogurt intake was also inversely associated with male rectal cancer mortality (HR = 0.5; 95% CI = 0.2-1.0; P for trend = 0.04). Egg consumption was positively associated with male colon cancer mortality (P for trend = 0.04). Women with high fruit consumption had increased colon cancer mortality (HR = 1.6; 95% CI = 1.0-2.6; P for trend = 0.04). It should be noted that this study lacked statistical power due to small sample size and measurement error in the food-frequency questionnaire. Further investigation is therefore necessary to confirm the association between diet and colorectal cancer, especially by subsites and gender.

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Kojima M, Wakai K, Tamakoshi K, Tokudome S, Toyoshima H, Watanabe Y et al. Diet and colorectal cancer mortality: Results from the Japan collaborative cohort study. Nutrition and Cancer. 2004 Jan 1;50(1):23-32. https://doi.org/10.1207/s15327914nc5001_4