Dietary fiber and risk of colorectal cancer in the Japan Collaborative Cohort Study

Kenji Wakai, Chigusa Date, Mitsuru Fukui, Koji Tamakoshi, Yoshiyuki Watanabe, Norihiko Hayakawa, Masayo Kojima, Miyuki Kawado, Koji Suzuki, Shuji Hashimoto, Shinkan Tokudome, Kotaro Ozasa, Sadao Suzuki, Hideaki Toyoshima, Yoshinori Ito, Akiko Tamakoshi

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Abstract

To examine the association of dietary fiber with the risk of colorectal cancer in a population with a high incidence of cancer and a low fiber intake, we analyzed the data from the Japan Collaborative Cohort Study. From 1988 to 1990, 43,115 men and women aged 40 to 79 years completed a questionnaire on dietary and other factors. Intake of dietary fiber was estimated using a food frequency questionnaire. Rate ratios (RR) were computed by fitting proportional hazards models. During the mean follow-up of 7.6 years, 443 colorectal cancer cases were recorded. In all participants, we found a decreasing trend in risk of colorectal cancer with increasing intake of total dietary fiber; the multivariate-adjusted RRs across quartiles were 1.00, 0.96 [95% confidence interval (95% CI), 0.72-1.27], 0.72 (0.53-0.99), and 0.73 (0.51-1.03; P trend = 0.028). This trend was exclusively detected for colon cancer: the corresponding RRs were 1.00,0.90 (95% CI, 0.64-1.26), 0.56 (0.38-0.83), and 0.58 (0.38-0.88; Ptrend = 0.002). The decrease in RRs with increasing intake of dietary fiber was larger in men than in women. No material differences appeared in the strength of associations with the risk between water-soluble and insoluble dietary fiber. For food sources of fiber, bean fiber intake was somewhat inversely correlated with colorectal cancer risk. This prospective study supported potential protective effects of dietary fiber against colorectal cancer, mainly against colon cancer. The role of dietary fiber in the prevention of colorectal cancer seems to remain inconsistent, and further investigations in various populations are warranted.

Original languageEnglish
Pages (from-to)668-675
Number of pages8
JournalCancer Epidemiology Biomarkers and Prevention
Volume16
Issue number4
DOIs
Publication statusPublished - 01-04-2007

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Dietary Fiber
Colorectal Neoplasms
Japan
Cohort Studies
Colonic Neoplasms
Confidence Intervals
Food
Proportional Hazards Models
Population
Prospective Studies
Water
Incidence
Neoplasms

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology

Cite this

Wakai, K., Date, C., Fukui, M., Tamakoshi, K., Watanabe, Y., Hayakawa, N., ... Tamakoshi, A. (2007). Dietary fiber and risk of colorectal cancer in the Japan Collaborative Cohort Study. Cancer Epidemiology Biomarkers and Prevention, 16(4), 668-675. https://doi.org/10.1158/1055-9965.EPI-06-0664
Wakai, Kenji ; Date, Chigusa ; Fukui, Mitsuru ; Tamakoshi, Koji ; Watanabe, Yoshiyuki ; Hayakawa, Norihiko ; Kojima, Masayo ; Kawado, Miyuki ; Suzuki, Koji ; Hashimoto, Shuji ; Tokudome, Shinkan ; Ozasa, Kotaro ; Suzuki, Sadao ; Toyoshima, Hideaki ; Ito, Yoshinori ; Tamakoshi, Akiko. / Dietary fiber and risk of colorectal cancer in the Japan Collaborative Cohort Study. In: Cancer Epidemiology Biomarkers and Prevention. 2007 ; Vol. 16, No. 4. pp. 668-675.
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Wakai, K, Date, C, Fukui, M, Tamakoshi, K, Watanabe, Y, Hayakawa, N, Kojima, M, Kawado, M, Suzuki, K, Hashimoto, S, Tokudome, S, Ozasa, K, Suzuki, S, Toyoshima, H, Ito, Y & Tamakoshi, A 2007, 'Dietary fiber and risk of colorectal cancer in the Japan Collaborative Cohort Study', Cancer Epidemiology Biomarkers and Prevention, vol. 16, no. 4, pp. 668-675. https://doi.org/10.1158/1055-9965.EPI-06-0664

Dietary fiber and risk of colorectal cancer in the Japan Collaborative Cohort Study. / Wakai, Kenji; Date, Chigusa; Fukui, Mitsuru; Tamakoshi, Koji; Watanabe, Yoshiyuki; Hayakawa, Norihiko; Kojima, Masayo; Kawado, Miyuki; Suzuki, Koji; Hashimoto, Shuji; Tokudome, Shinkan; Ozasa, Kotaro; Suzuki, Sadao; Toyoshima, Hideaki; Ito, Yoshinori; Tamakoshi, Akiko.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 16, No. 4, 01.04.2007, p. 668-675.

Research output: Contribution to journalArticle

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T1 - Dietary fiber and risk of colorectal cancer in the Japan Collaborative Cohort Study

AU - Wakai, Kenji

AU - Date, Chigusa

AU - Fukui, Mitsuru

AU - Tamakoshi, Koji

AU - Watanabe, Yoshiyuki

AU - Hayakawa, Norihiko

AU - Kojima, Masayo

AU - Kawado, Miyuki

AU - Suzuki, Koji

AU - Hashimoto, Shuji

AU - Tokudome, Shinkan

AU - Ozasa, Kotaro

AU - Suzuki, Sadao

AU - Toyoshima, Hideaki

AU - Ito, Yoshinori

AU - Tamakoshi, Akiko

PY - 2007/4/1

Y1 - 2007/4/1

N2 - To examine the association of dietary fiber with the risk of colorectal cancer in a population with a high incidence of cancer and a low fiber intake, we analyzed the data from the Japan Collaborative Cohort Study. From 1988 to 1990, 43,115 men and women aged 40 to 79 years completed a questionnaire on dietary and other factors. Intake of dietary fiber was estimated using a food frequency questionnaire. Rate ratios (RR) were computed by fitting proportional hazards models. During the mean follow-up of 7.6 years, 443 colorectal cancer cases were recorded. In all participants, we found a decreasing trend in risk of colorectal cancer with increasing intake of total dietary fiber; the multivariate-adjusted RRs across quartiles were 1.00, 0.96 [95% confidence interval (95% CI), 0.72-1.27], 0.72 (0.53-0.99), and 0.73 (0.51-1.03; P trend = 0.028). This trend was exclusively detected for colon cancer: the corresponding RRs were 1.00,0.90 (95% CI, 0.64-1.26), 0.56 (0.38-0.83), and 0.58 (0.38-0.88; Ptrend = 0.002). The decrease in RRs with increasing intake of dietary fiber was larger in men than in women. No material differences appeared in the strength of associations with the risk between water-soluble and insoluble dietary fiber. For food sources of fiber, bean fiber intake was somewhat inversely correlated with colorectal cancer risk. This prospective study supported potential protective effects of dietary fiber against colorectal cancer, mainly against colon cancer. The role of dietary fiber in the prevention of colorectal cancer seems to remain inconsistent, and further investigations in various populations are warranted.

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