Dietary flax oil rich in α-linolenic acid reduces renal disease and oxylipin abnormalities, including formation of docosahexaenoic acid derived oxylipins in the CD1-pcy/pcy mouse model of nephronophthisis

Tamio Yamaguchi, Jessay G. Devassy, Melissa Gabbs, Amir Ravandi, Shizuko Nagao, Harold M. Aukema

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The CD1-. pcy/pcy mouse model of nephronophthisis displays reduced renal docosahexaenoic acid (DHA) levels and alterations in renal cyclooxygenase and lipoxygenase oxylipins derived from n-6 fatty acids. Since dietary flax oil ameliorates disease progression, its effect on renal fatty acids and oxylipins was examined. Sixteen weeks of feeding resulted in reduced disease progression and enrichment of renal phospholipid α-linolenic acid (ALA) and eicosapentaenoic acid, reduction in arachidonic acid (AA), but no change in linoleic acid (LA) or DHA. In diseased kidneys, flax oil feeding mitigated the elevated levels of renal cyclooxygenase derived oxylipins formed from AA and the lowered lipoxygenase and cytochrome P450 derived oxylipins formed from ALA and DHA. Increased DHA oxylipins occurred with flax feeding despite not altering DHA levels. Dietary flax oil may therefore reduce disease progression via mitigation of oxylipin abnormalities. This study also provides evidence of in vivo ALA conversion to DHA in amounts necessary to restore DHA oxylipin levels.

Original languageEnglish
Pages (from-to)83-89
Number of pages7
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume94
DOIs
Publication statusPublished - 01-03-2015

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Oxylipins
Unsaturated Dietary Fats
Flax
alpha-Linolenic Acid
Docosahexaenoic Acids
Oils
Kidney
Disease Progression
Prostaglandin-Endoperoxide Synthases
Fatty Acids
Arachidonate Lipoxygenases
Eicosapentaenoic Acid
Lipoxygenase
Kidney Diseases
Linoleic Acid
Arachidonic Acid
Cytochrome P-450 Enzyme System
Phospholipids
Display devices

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Cell Biology

Cite this

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title = "Dietary flax oil rich in α-linolenic acid reduces renal disease and oxylipin abnormalities, including formation of docosahexaenoic acid derived oxylipins in the CD1-pcy/pcy mouse model of nephronophthisis",
abstract = "The CD1-. pcy/pcy mouse model of nephronophthisis displays reduced renal docosahexaenoic acid (DHA) levels and alterations in renal cyclooxygenase and lipoxygenase oxylipins derived from n-6 fatty acids. Since dietary flax oil ameliorates disease progression, its effect on renal fatty acids and oxylipins was examined. Sixteen weeks of feeding resulted in reduced disease progression and enrichment of renal phospholipid α-linolenic acid (ALA) and eicosapentaenoic acid, reduction in arachidonic acid (AA), but no change in linoleic acid (LA) or DHA. In diseased kidneys, flax oil feeding mitigated the elevated levels of renal cyclooxygenase derived oxylipins formed from AA and the lowered lipoxygenase and cytochrome P450 derived oxylipins formed from ALA and DHA. Increased DHA oxylipins occurred with flax feeding despite not altering DHA levels. Dietary flax oil may therefore reduce disease progression via mitigation of oxylipin abnormalities. This study also provides evidence of in vivo ALA conversion to DHA in amounts necessary to restore DHA oxylipin levels.",
author = "Tamio Yamaguchi and Devassy, {Jessay G.} and Melissa Gabbs and Amir Ravandi and Shizuko Nagao and Aukema, {Harold M.}",
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T1 - Dietary flax oil rich in α-linolenic acid reduces renal disease and oxylipin abnormalities, including formation of docosahexaenoic acid derived oxylipins in the CD1-pcy/pcy mouse model of nephronophthisis

AU - Yamaguchi, Tamio

AU - Devassy, Jessay G.

AU - Gabbs, Melissa

AU - Ravandi, Amir

AU - Nagao, Shizuko

AU - Aukema, Harold M.

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