TY - JOUR
T1 - Dietary inflammatory index is associated with risk of all-cause and cardiovascular disease mortality but not with cancer mortality in middle-aged and older Japanese adults
AU - Okada, Emiko
AU - Shirakawa, Toru
AU - Shivappa, Nitin
AU - Wakai, Kenji
AU - Suzuki, Koji
AU - Date, Chigusa
AU - Iso, Hiroyasu
AU - Hébert, James R.
AU - Tamakoshi, Akiko
N1 - Funding Information:
This study was funded by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (Monbusho); Grants-in-Aid for Scientific Research on Priority Areas of Cancer and Grants-in-Aid for Scientific Research on Priority Areas of Cancer Epidemiology from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (Monbukagakusho) (grants 61010076, 62010074, 63010074, 1010068, 2151065, 3151064, 4151063, 5151069, 6279102, 11181101, 17015022, 18014011, 20014026, 20390156, and 16H06277); grants-in-aid from the Ministry of Health, Labour and Welfare, Health and Labour Sciences research grants, Japan [Research on Health Services: H17-Kenkou-007; Comprehensive Research on Cardiovascular Disease and Life-Related Disease: H18-Junkankitou (Seishuu)-Ippan-012; Comprehensive Research on Cardiovascular Disease and Life-Style Related Disease: H19-Junkankitou (Seishuu)-Ippan-012; Comprehensive Research on Cardiovascular and Life-Style Related Diseases: H20-Junkankitou (Seishuu)-Ippan-013; Comprehensive Research on Cardiovascular and Life-Style Related Diseases: H23-Junkankitou (Seishuu)-Ippan-005]; an Intramural Research Fund (22-4-5) for Cardiovascular Diseases from the National Cerebral and Cardiovascular Center; and Comprehensive Research on Cardiovascular and Life-Style Related Diseases [H26-Junkankitou (Seisaku)-Ippan-001 and H29-Junkankitou (Seishuu)-Ippan-003]. Author disclosures: JRH owns a controlling interest in Connecting Health Innovations LLC, a company of the University of South Carolina that has licensed the right to his invention of the Dietary Inflammatory Index in order to develop computer and smartphone applications for patient counseling and dietary intervention in clinical settings. NS is employed by Connecting Health Innovations. The subject matter of this paper will not have any direct bearing on that work, nor has that activity exerted any influence on this project. EO, TS, NS, KW, KS, CD, HI, JRH, and AT, no conflicts of interests. Address correspondence to AT (e-mail: tamaa@med.hokudai.ac.jp). Abbreviations used: CHD, coronary heart disease; CRP, C-reactive protein; CVD, cardiovascular disease; DII, Dietary Inflammatory Index; hs-CRP, high-sensitivity C-reactive protein; JACC Study, Japan Collaborative Cohort Study; MI, myocardial infarction.
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Background: The Dietary Inflammatory Index (DII) is a comprehensive, literature-derived index for assessing the effect of dietary constituents on inflammatory biomarkers. Several studies have shown an association between DII score and mortality, but there are limited prospective studies in Asian populations. Objectives: The aim of this study was to investigate the association between DII score and risk of all-cause, total cardiovascular disease (CVD), stroke, coronary heart disease (CHD), total cancer, digestive cancer, and noncancer/non-CVD mortality in the Japanese population. Methods: A total of 58,782 Japanese participants aged 40-79 y who were enrolled in the Japan Collaborative Cohort Study during 1988-1990 were included in the analysis. DII scores were calculated based on a food-frequency questionnaire. HRs and 95% CIs for mortality according to DII quintiles were estimated using Cox proportional hazards models. Results: During the median follow-up period of 19.3 y, a total of 11,693 participants died. The multivariable HR for all-cause mortality for the highest compared with the lowest DII quintiles was 1.13 (95% CI: 1.05, 1.21). For CVD mortality, the highest multivariable HRs were 1.30 (95% CI: 1.13, 1.49), 1.29 (95% CI: 1.05, 1.59), and 1.30 (95% CI: 0.96, 1.76) for total CVD, stroke, and CHD, respectively. No significant associations were observed between DII and risk of total cancer, digestive cancer, and noncancer/non-CVD mortality. Conclusion: Our findings suggest that a higher DII was associated with an increased risk of all-cause and CVD mortality among Japanese adults.
AB - Background: The Dietary Inflammatory Index (DII) is a comprehensive, literature-derived index for assessing the effect of dietary constituents on inflammatory biomarkers. Several studies have shown an association between DII score and mortality, but there are limited prospective studies in Asian populations. Objectives: The aim of this study was to investigate the association between DII score and risk of all-cause, total cardiovascular disease (CVD), stroke, coronary heart disease (CHD), total cancer, digestive cancer, and noncancer/non-CVD mortality in the Japanese population. Methods: A total of 58,782 Japanese participants aged 40-79 y who were enrolled in the Japan Collaborative Cohort Study during 1988-1990 were included in the analysis. DII scores were calculated based on a food-frequency questionnaire. HRs and 95% CIs for mortality according to DII quintiles were estimated using Cox proportional hazards models. Results: During the median follow-up period of 19.3 y, a total of 11,693 participants died. The multivariable HR for all-cause mortality for the highest compared with the lowest DII quintiles was 1.13 (95% CI: 1.05, 1.21). For CVD mortality, the highest multivariable HRs were 1.30 (95% CI: 1.13, 1.49), 1.29 (95% CI: 1.05, 1.59), and 1.30 (95% CI: 0.96, 1.76) for total CVD, stroke, and CHD, respectively. No significant associations were observed between DII and risk of total cancer, digestive cancer, and noncancer/non-CVD mortality. Conclusion: Our findings suggest that a higher DII was associated with an increased risk of all-cause and CVD mortality among Japanese adults.
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U2 - 10.1093/jn/nxz085
DO - 10.1093/jn/nxz085
M3 - Article
C2 - 31100121
AN - SCOPUS:85071060732
VL - 149
SP - 1451
EP - 1459
JO - Journal of Nutrition
JF - Journal of Nutrition
SN - 0022-3166
IS - 8
ER -