Dietary instructions focusing on meal-sequence and nutritional balance for prediabetes subjects: An exploratory, cluster-randomized, prospective, open-label, clinical trial

Daisuke Yabe, Hitoshi Kuwata, Yuuka Fujiwara, Mayuka Sakaguchi, Shota Moyama, Noboru Makabe, Kenta Murotani, Hiroshi Asano, Sanae Ito, Hideyuki Mishima, Hideto Takase, Noriyasu Ota, Yusuke Seino, Yoshiyuki Hamamoto, Takeshi Kurose, Yutaka Seino

Research output: Contribution to journalArticle

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Abstract

Background: Although lifestyle modifications are known to be effective in type 2 diabetes (T2D) as well as in prediabetes, adherence to a healthy diet is difficult for some, and interventions of lifestyle modifications need to be revised occasionally. Meal sequence has been gaining attention as a part of a healthy diet among T2D individuals to improve glycemia and body weight. In addition, a dietary instruction program, SMART Washoku®, which can help individuals to consume a more nutritionally balanced diet, has been developed. Methods: The current exploratory trial was designed to examine the effects of dietary instructions focusing on meal sequence and nutritional balance in individuals with prediabetes in the Japanese national health check-up and guidance program. Participants were cluster-randomized into three groups: Group A, receiving a conventional health guidance program (n = 11); Group B, receiving health guidance with dietary instructions focusing on meal sequence (n = 18); and Group C, receiving health guidance with dietary instructions focusing on nutritional balance (n = 13). Participants received health guidance education and various measurements before and 6 months after the instructions. Results: Body weight in Group B was significantly reduced compared to that in Group A, with similar adherence, while the effects on glycemia were similar between the two Groups. Body weight reduction was greater in Group C compared to that in Group A, although adherence in Group C was significantly lower than that in Group A. Conclusion: The group receiving health guidance with dietary instructions focusing on meal sequence exhibited similar adherence and greater reduction in body weight than the group receiving conventional health guidance.

Original languageEnglish
Article number107450
JournalJournal of Diabetes and its Complications
Volume33
Issue number12
DOIs
Publication statusPublished - 12-2019

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Yabe, D., Kuwata, H., Fujiwara, Y., Sakaguchi, M., Moyama, S., Makabe, N., Murotani, K., Asano, H., Ito, S., Mishima, H., Takase, H., Ota, N., Seino, Y., Hamamoto, Y., Kurose, T., & Seino, Y. (2019). Dietary instructions focusing on meal-sequence and nutritional balance for prediabetes subjects: An exploratory, cluster-randomized, prospective, open-label, clinical trial. Journal of Diabetes and its Complications, 33(12), [107450]. https://doi.org/10.1016/j.jdiacomp.2019.107450