Dietary intake of saturated fatty acids and mortality from cardiovascular disease in Japanese

The Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC) study

Kazumasa Yamagishi, Hiroyasu Iso, Hiroshi Yatsuya, Naohito Tanabe, Chigusa Date, Shogo Kikuchi, Akio Yamamoto, Yutaka Inaba, Akiko Tamakoshi

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Background: Prospective epidemiologic studies have generated mixed results regarding the association between saturated fatty acid (SFA) intake and risk of ischemic heart disease (IHD) and stroke. These associations have not been extensively studied in Asians. Objective: The aim of this study was to test the hypothesis that SFA intake is associated with the risk of cardiovascular disease mortality in Japanese whose average SFA intake is low. Design: The Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study) comprised 58,453 Japanese men and women who completed a food-frequency questionnaire. Participants were aged 40-79 y at baseline (1988-1990) and were followed up for 14.1 y. Associations of energy-adjusted SFA intake with mortality from stroke (intraparenchymal and subarachnoid hemorrhages and ischemic stroke) and heart diseases (IHD, cardiac arrest, and heart failure) were examined after adjustment for age, sex, and cardiovascular disease risk and dietary factors. Results: We observed inverse associations of SFA intake with mortality from total stroke [n = 976; multivariable hazard ratio (95% CI) for highest compared with lowest quintiles: 0.69 (0.53, 0.89); P for trend = 0.004], intraparenchymal hemorrhage [n = 224; 0.48 (0.27, 0.85); P for trend = 0.03], and ischemic stroke [n = 321; 0.58 (0.37, 0.90); P for trend = 0.01]. No multivariable-adjusted associations were observed between SFA and mortality from subarachnoid hemorrhage [n = 153; 0.91 (0.46, 1.80); P for trend = 0.47] and heart disease [n = 836; 0.89 (0.68, 1.15); P for trend = 1.59]. Conclusion: SFA intake was inversely associated with mortality from total stroke, including intraparenchymal hemorrhage and ischemic stroke subtypes, in this Japanese cohort.

Original languageEnglish
Pages (from-to)759-765
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume92
Issue number4
DOIs
Publication statusPublished - 01-10-2010
Externally publishedYes

Fingerprint

Japan
Cohort Studies
Cardiovascular Diseases
Fatty Acids
Stroke
Mortality
Neoplasms
Myocardial Ischemia
Subarachnoid Hemorrhage
Heart Failure
Hemorrhage
Heart Arrest
Epidemiologic Studies
Heart Diseases
Prospective Studies
Food

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Yamagishi, Kazumasa ; Iso, Hiroyasu ; Yatsuya, Hiroshi ; Tanabe, Naohito ; Date, Chigusa ; Kikuchi, Shogo ; Yamamoto, Akio ; Inaba, Yutaka ; Tamakoshi, Akiko. / Dietary intake of saturated fatty acids and mortality from cardiovascular disease in Japanese : The Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC) study. In: American Journal of Clinical Nutrition. 2010 ; Vol. 92, No. 4. pp. 759-765.
@article{06b38cbff47a4dfcac03c2921752d502,
title = "Dietary intake of saturated fatty acids and mortality from cardiovascular disease in Japanese: The Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC) study",
abstract = "Background: Prospective epidemiologic studies have generated mixed results regarding the association between saturated fatty acid (SFA) intake and risk of ischemic heart disease (IHD) and stroke. These associations have not been extensively studied in Asians. Objective: The aim of this study was to test the hypothesis that SFA intake is associated with the risk of cardiovascular disease mortality in Japanese whose average SFA intake is low. Design: The Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study) comprised 58,453 Japanese men and women who completed a food-frequency questionnaire. Participants were aged 40-79 y at baseline (1988-1990) and were followed up for 14.1 y. Associations of energy-adjusted SFA intake with mortality from stroke (intraparenchymal and subarachnoid hemorrhages and ischemic stroke) and heart diseases (IHD, cardiac arrest, and heart failure) were examined after adjustment for age, sex, and cardiovascular disease risk and dietary factors. Results: We observed inverse associations of SFA intake with mortality from total stroke [n = 976; multivariable hazard ratio (95{\%} CI) for highest compared with lowest quintiles: 0.69 (0.53, 0.89); P for trend = 0.004], intraparenchymal hemorrhage [n = 224; 0.48 (0.27, 0.85); P for trend = 0.03], and ischemic stroke [n = 321; 0.58 (0.37, 0.90); P for trend = 0.01]. No multivariable-adjusted associations were observed between SFA and mortality from subarachnoid hemorrhage [n = 153; 0.91 (0.46, 1.80); P for trend = 0.47] and heart disease [n = 836; 0.89 (0.68, 1.15); P for trend = 1.59]. Conclusion: SFA intake was inversely associated with mortality from total stroke, including intraparenchymal hemorrhage and ischemic stroke subtypes, in this Japanese cohort.",
author = "Kazumasa Yamagishi and Hiroyasu Iso and Hiroshi Yatsuya and Naohito Tanabe and Chigusa Date and Shogo Kikuchi and Akio Yamamoto and Yutaka Inaba and Akiko Tamakoshi",
year = "2010",
month = "10",
day = "1",
doi = "10.3945/ajcn.2009.29146",
language = "English",
volume = "92",
pages = "759--765",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "4",

}

Dietary intake of saturated fatty acids and mortality from cardiovascular disease in Japanese : The Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC) study. / Yamagishi, Kazumasa; Iso, Hiroyasu; Yatsuya, Hiroshi; Tanabe, Naohito; Date, Chigusa; Kikuchi, Shogo; Yamamoto, Akio; Inaba, Yutaka; Tamakoshi, Akiko.

In: American Journal of Clinical Nutrition, Vol. 92, No. 4, 01.10.2010, p. 759-765.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Dietary intake of saturated fatty acids and mortality from cardiovascular disease in Japanese

T2 - The Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC) study

AU - Yamagishi, Kazumasa

AU - Iso, Hiroyasu

AU - Yatsuya, Hiroshi

AU - Tanabe, Naohito

AU - Date, Chigusa

AU - Kikuchi, Shogo

AU - Yamamoto, Akio

AU - Inaba, Yutaka

AU - Tamakoshi, Akiko

PY - 2010/10/1

Y1 - 2010/10/1

N2 - Background: Prospective epidemiologic studies have generated mixed results regarding the association between saturated fatty acid (SFA) intake and risk of ischemic heart disease (IHD) and stroke. These associations have not been extensively studied in Asians. Objective: The aim of this study was to test the hypothesis that SFA intake is associated with the risk of cardiovascular disease mortality in Japanese whose average SFA intake is low. Design: The Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study) comprised 58,453 Japanese men and women who completed a food-frequency questionnaire. Participants were aged 40-79 y at baseline (1988-1990) and were followed up for 14.1 y. Associations of energy-adjusted SFA intake with mortality from stroke (intraparenchymal and subarachnoid hemorrhages and ischemic stroke) and heart diseases (IHD, cardiac arrest, and heart failure) were examined after adjustment for age, sex, and cardiovascular disease risk and dietary factors. Results: We observed inverse associations of SFA intake with mortality from total stroke [n = 976; multivariable hazard ratio (95% CI) for highest compared with lowest quintiles: 0.69 (0.53, 0.89); P for trend = 0.004], intraparenchymal hemorrhage [n = 224; 0.48 (0.27, 0.85); P for trend = 0.03], and ischemic stroke [n = 321; 0.58 (0.37, 0.90); P for trend = 0.01]. No multivariable-adjusted associations were observed between SFA and mortality from subarachnoid hemorrhage [n = 153; 0.91 (0.46, 1.80); P for trend = 0.47] and heart disease [n = 836; 0.89 (0.68, 1.15); P for trend = 1.59]. Conclusion: SFA intake was inversely associated with mortality from total stroke, including intraparenchymal hemorrhage and ischemic stroke subtypes, in this Japanese cohort.

AB - Background: Prospective epidemiologic studies have generated mixed results regarding the association between saturated fatty acid (SFA) intake and risk of ischemic heart disease (IHD) and stroke. These associations have not been extensively studied in Asians. Objective: The aim of this study was to test the hypothesis that SFA intake is associated with the risk of cardiovascular disease mortality in Japanese whose average SFA intake is low. Design: The Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study) comprised 58,453 Japanese men and women who completed a food-frequency questionnaire. Participants were aged 40-79 y at baseline (1988-1990) and were followed up for 14.1 y. Associations of energy-adjusted SFA intake with mortality from stroke (intraparenchymal and subarachnoid hemorrhages and ischemic stroke) and heart diseases (IHD, cardiac arrest, and heart failure) were examined after adjustment for age, sex, and cardiovascular disease risk and dietary factors. Results: We observed inverse associations of SFA intake with mortality from total stroke [n = 976; multivariable hazard ratio (95% CI) for highest compared with lowest quintiles: 0.69 (0.53, 0.89); P for trend = 0.004], intraparenchymal hemorrhage [n = 224; 0.48 (0.27, 0.85); P for trend = 0.03], and ischemic stroke [n = 321; 0.58 (0.37, 0.90); P for trend = 0.01]. No multivariable-adjusted associations were observed between SFA and mortality from subarachnoid hemorrhage [n = 153; 0.91 (0.46, 1.80); P for trend = 0.47] and heart disease [n = 836; 0.89 (0.68, 1.15); P for trend = 1.59]. Conclusion: SFA intake was inversely associated with mortality from total stroke, including intraparenchymal hemorrhage and ischemic stroke subtypes, in this Japanese cohort.

UR - http://www.scopus.com/inward/record.url?scp=78049419532&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78049419532&partnerID=8YFLogxK

U2 - 10.3945/ajcn.2009.29146

DO - 10.3945/ajcn.2009.29146

M3 - Article

VL - 92

SP - 759

EP - 765

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 4

ER -