Dietary intakes of fat and fatty acids and risk of breast cancer

A prospective study in Japan

Kenji Wakai, Koji Tamakoshi, Chigusa Date, Mitsuru Fukui, Sadao Suzuki, Yingsong Lin, Yoshimitsu Niwa, Kazuko Nishio, Hiroshi Yatsuya, Takaaki Kondo, Shinkan Tokudome, Akio Yamamoto, Hideaki Toyoshima, Akiko Tamakoshi, Mitsuru Mori, Yutaka Motohashi, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami & 30 others Yutaka Inaba, Yoshiharu Hoshiyama, Hiroshi Suzuki, Hiroyuki Shimizu, Yoshinori Ito, Shuji Hashimoto, Shogo Kikuchi, Akio Koizumi, Takashi Kawamura, Yoshiyuki Watanabe, Tsuneharu Miki, Kiyomi Sakata, Takayuki Nose, Norihiko Hayakawa, Takesumi Yoshimura, Akira Shibata, Naoyuki Okamoto, Hideo Shio, Yoshiyuki Ohno, Tomoyuki Kitagawa, Toshio Kuroki, Kazuo Tajima, Takashi Shimamoto, Heizo Tanaka, Shigeru Hisamichi, Masahiro Nakao, Takaichiro Suzuki, Tsutomu Hashimoto, Teruo Ishibashi, Katsuhiro Fukuda

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

To examine the possible association of dietary fat and fatty acids with breast cancer risk in a population with a low total fat intake and a high consumption of fish, we analyzed data from the Japan Collaborative Cohort (JACC) Study. From 1988 to 1990, 26 291 women aged 40-79 years completed a questionnaire on dietary and other factors. Intakes of fat or fatty acids were estimated by using a food frequency questionnaire. Rate ratios (RR) were computed by fitting proportional hazards models. During the mean follow-up of 7.6 years, 129 breast cancer cases were documented. We found no clear association of total fat intake with breast cancer risk; the multivariate-adjusted RR across quartiles were 1.00, 1.29, 0.95, and 0.80 (95% confidence interval [CI] 0.46-1.38). A significant decrease in the risk was detected for the highest quartile of intake compared with the lowest for fish fat and long-chain n-3 fatty acids; the RR were 0.56 (95% CI 0.33-0.94) and 0.50 (0.30-0.85), respectively. A decreasing trend in risk was also suggested with an increasing intake of saturated fatty acids (trend P = 0.066). Among postmenopausal women at baseline, the highest quartile of vegetable fat intake was associated with a 2.08-fold increase in risk (95% CI 1.05-4.13). This prospective study did not support any increase in the risk of breast cancer associated with total or saturated fat intake, but it suggested the protective effects of the long-chain n-3 fatty acids that are abundant in fish.

Original languageEnglish
Pages (from-to)590-599
Number of pages10
JournalCancer Science
Volume96
Issue number9
DOIs
Publication statusPublished - 01-09-2005

Fingerprint

Dietary Fats
Japan
Fatty Acids
Fats
Prospective Studies
Breast Neoplasms
Fishes
Omega-3 Fatty Acids
Confidence Intervals
Proportional Hazards Models
Vegetables
Cohort Studies
Food
Population

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Wakai, K., Tamakoshi, K., Date, C., Fukui, M., Suzuki, S., Lin, Y., ... Fukuda, K. (2005). Dietary intakes of fat and fatty acids and risk of breast cancer: A prospective study in Japan. Cancer Science, 96(9), 590-599. https://doi.org/10.1111/j.1349-7006.2005.00084.x
Wakai, Kenji ; Tamakoshi, Koji ; Date, Chigusa ; Fukui, Mitsuru ; Suzuki, Sadao ; Lin, Yingsong ; Niwa, Yoshimitsu ; Nishio, Kazuko ; Yatsuya, Hiroshi ; Kondo, Takaaki ; Tokudome, Shinkan ; Yamamoto, Akio ; Toyoshima, Hideaki ; Tamakoshi, Akiko ; Mori, Mitsuru ; Motohashi, Yutaka ; Tsuji, Ichiro ; Nakamura, Yosikazu ; Iso, Hiroyasu ; Mikami, Haruo ; Inaba, Yutaka ; Hoshiyama, Yoshiharu ; Suzuki, Hiroshi ; Shimizu, Hiroyuki ; Ito, Yoshinori ; Hashimoto, Shuji ; Kikuchi, Shogo ; Koizumi, Akio ; Kawamura, Takashi ; Watanabe, Yoshiyuki ; Miki, Tsuneharu ; Sakata, Kiyomi ; Nose, Takayuki ; Hayakawa, Norihiko ; Yoshimura, Takesumi ; Shibata, Akira ; Okamoto, Naoyuki ; Shio, Hideo ; Ohno, Yoshiyuki ; Kitagawa, Tomoyuki ; Kuroki, Toshio ; Tajima, Kazuo ; Shimamoto, Takashi ; Tanaka, Heizo ; Hisamichi, Shigeru ; Nakao, Masahiro ; Suzuki, Takaichiro ; Hashimoto, Tsutomu ; Ishibashi, Teruo ; Fukuda, Katsuhiro. / Dietary intakes of fat and fatty acids and risk of breast cancer : A prospective study in Japan. In: Cancer Science. 2005 ; Vol. 96, No. 9. pp. 590-599.
@article{905b9639a2b34a0183a54b91b7f2ac3b,
title = "Dietary intakes of fat and fatty acids and risk of breast cancer: A prospective study in Japan",
abstract = "To examine the possible association of dietary fat and fatty acids with breast cancer risk in a population with a low total fat intake and a high consumption of fish, we analyzed data from the Japan Collaborative Cohort (JACC) Study. From 1988 to 1990, 26 291 women aged 40-79 years completed a questionnaire on dietary and other factors. Intakes of fat or fatty acids were estimated by using a food frequency questionnaire. Rate ratios (RR) were computed by fitting proportional hazards models. During the mean follow-up of 7.6 years, 129 breast cancer cases were documented. We found no clear association of total fat intake with breast cancer risk; the multivariate-adjusted RR across quartiles were 1.00, 1.29, 0.95, and 0.80 (95{\%} confidence interval [CI] 0.46-1.38). A significant decrease in the risk was detected for the highest quartile of intake compared with the lowest for fish fat and long-chain n-3 fatty acids; the RR were 0.56 (95{\%} CI 0.33-0.94) and 0.50 (0.30-0.85), respectively. A decreasing trend in risk was also suggested with an increasing intake of saturated fatty acids (trend P = 0.066). Among postmenopausal women at baseline, the highest quartile of vegetable fat intake was associated with a 2.08-fold increase in risk (95{\%} CI 1.05-4.13). This prospective study did not support any increase in the risk of breast cancer associated with total or saturated fat intake, but it suggested the protective effects of the long-chain n-3 fatty acids that are abundant in fish.",
author = "Kenji Wakai and Koji Tamakoshi and Chigusa Date and Mitsuru Fukui and Sadao Suzuki and Yingsong Lin and Yoshimitsu Niwa and Kazuko Nishio and Hiroshi Yatsuya and Takaaki Kondo and Shinkan Tokudome and Akio Yamamoto and Hideaki Toyoshima and Akiko Tamakoshi and Mitsuru Mori and Yutaka Motohashi and Ichiro Tsuji and Yosikazu Nakamura and Hiroyasu Iso and Haruo Mikami and Yutaka Inaba and Yoshiharu Hoshiyama and Hiroshi Suzuki and Hiroyuki Shimizu and Yoshinori Ito and Shuji Hashimoto and Shogo Kikuchi and Akio Koizumi and Takashi Kawamura and Yoshiyuki Watanabe and Tsuneharu Miki and Kiyomi Sakata and Takayuki Nose and Norihiko Hayakawa and Takesumi Yoshimura and Akira Shibata and Naoyuki Okamoto and Hideo Shio and Yoshiyuki Ohno and Tomoyuki Kitagawa and Toshio Kuroki and Kazuo Tajima and Takashi Shimamoto and Heizo Tanaka and Shigeru Hisamichi and Masahiro Nakao and Takaichiro Suzuki and Tsutomu Hashimoto and Teruo Ishibashi and Katsuhiro Fukuda",
year = "2005",
month = "9",
day = "1",
doi = "10.1111/j.1349-7006.2005.00084.x",
language = "English",
volume = "96",
pages = "590--599",
journal = "Cancer Science",
issn = "1347-9032",
publisher = "Wiley-Blackwell",
number = "9",

}

Wakai, K, Tamakoshi, K, Date, C, Fukui, M, Suzuki, S, Lin, Y, Niwa, Y, Nishio, K, Yatsuya, H, Kondo, T, Tokudome, S, Yamamoto, A, Toyoshima, H, Tamakoshi, A, Mori, M, Motohashi, Y, Tsuji, I, Nakamura, Y, Iso, H, Mikami, H, Inaba, Y, Hoshiyama, Y, Suzuki, H, Shimizu, H, Ito, Y, Hashimoto, S, Kikuchi, S, Koizumi, A, Kawamura, T, Watanabe, Y, Miki, T, Sakata, K, Nose, T, Hayakawa, N, Yoshimura, T, Shibata, A, Okamoto, N, Shio, H, Ohno, Y, Kitagawa, T, Kuroki, T, Tajima, K, Shimamoto, T, Tanaka, H, Hisamichi, S, Nakao, M, Suzuki, T, Hashimoto, T, Ishibashi, T & Fukuda, K 2005, 'Dietary intakes of fat and fatty acids and risk of breast cancer: A prospective study in Japan', Cancer Science, vol. 96, no. 9, pp. 590-599. https://doi.org/10.1111/j.1349-7006.2005.00084.x

Dietary intakes of fat and fatty acids and risk of breast cancer : A prospective study in Japan. / Wakai, Kenji; Tamakoshi, Koji; Date, Chigusa; Fukui, Mitsuru; Suzuki, Sadao; Lin, Yingsong; Niwa, Yoshimitsu; Nishio, Kazuko; Yatsuya, Hiroshi; Kondo, Takaaki; Tokudome, Shinkan; Yamamoto, Akio; Toyoshima, Hideaki; Tamakoshi, Akiko; Mori, Mitsuru; Motohashi, Yutaka; Tsuji, Ichiro; Nakamura, Yosikazu; Iso, Hiroyasu; Mikami, Haruo; Inaba, Yutaka; Hoshiyama, Yoshiharu; Suzuki, Hiroshi; Shimizu, Hiroyuki; Ito, Yoshinori; Hashimoto, Shuji; Kikuchi, Shogo; Koizumi, Akio; Kawamura, Takashi; Watanabe, Yoshiyuki; Miki, Tsuneharu; Sakata, Kiyomi; Nose, Takayuki; Hayakawa, Norihiko; Yoshimura, Takesumi; Shibata, Akira; Okamoto, Naoyuki; Shio, Hideo; Ohno, Yoshiyuki; Kitagawa, Tomoyuki; Kuroki, Toshio; Tajima, Kazuo; Shimamoto, Takashi; Tanaka, Heizo; Hisamichi, Shigeru; Nakao, Masahiro; Suzuki, Takaichiro; Hashimoto, Tsutomu; Ishibashi, Teruo; Fukuda, Katsuhiro.

In: Cancer Science, Vol. 96, No. 9, 01.09.2005, p. 590-599.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Dietary intakes of fat and fatty acids and risk of breast cancer

T2 - A prospective study in Japan

AU - Wakai, Kenji

AU - Tamakoshi, Koji

AU - Date, Chigusa

AU - Fukui, Mitsuru

AU - Suzuki, Sadao

AU - Lin, Yingsong

AU - Niwa, Yoshimitsu

AU - Nishio, Kazuko

AU - Yatsuya, Hiroshi

AU - Kondo, Takaaki

AU - Tokudome, Shinkan

AU - Yamamoto, Akio

AU - Toyoshima, Hideaki

AU - Tamakoshi, Akiko

AU - Mori, Mitsuru

AU - Motohashi, Yutaka

AU - Tsuji, Ichiro

AU - Nakamura, Yosikazu

AU - Iso, Hiroyasu

AU - Mikami, Haruo

AU - Inaba, Yutaka

AU - Hoshiyama, Yoshiharu

AU - Suzuki, Hiroshi

AU - Shimizu, Hiroyuki

AU - Ito, Yoshinori

AU - Hashimoto, Shuji

AU - Kikuchi, Shogo

AU - Koizumi, Akio

AU - Kawamura, Takashi

AU - Watanabe, Yoshiyuki

AU - Miki, Tsuneharu

AU - Sakata, Kiyomi

AU - Nose, Takayuki

AU - Hayakawa, Norihiko

AU - Yoshimura, Takesumi

AU - Shibata, Akira

AU - Okamoto, Naoyuki

AU - Shio, Hideo

AU - Ohno, Yoshiyuki

AU - Kitagawa, Tomoyuki

AU - Kuroki, Toshio

AU - Tajima, Kazuo

AU - Shimamoto, Takashi

AU - Tanaka, Heizo

AU - Hisamichi, Shigeru

AU - Nakao, Masahiro

AU - Suzuki, Takaichiro

AU - Hashimoto, Tsutomu

AU - Ishibashi, Teruo

AU - Fukuda, Katsuhiro

PY - 2005/9/1

Y1 - 2005/9/1

N2 - To examine the possible association of dietary fat and fatty acids with breast cancer risk in a population with a low total fat intake and a high consumption of fish, we analyzed data from the Japan Collaborative Cohort (JACC) Study. From 1988 to 1990, 26 291 women aged 40-79 years completed a questionnaire on dietary and other factors. Intakes of fat or fatty acids were estimated by using a food frequency questionnaire. Rate ratios (RR) were computed by fitting proportional hazards models. During the mean follow-up of 7.6 years, 129 breast cancer cases were documented. We found no clear association of total fat intake with breast cancer risk; the multivariate-adjusted RR across quartiles were 1.00, 1.29, 0.95, and 0.80 (95% confidence interval [CI] 0.46-1.38). A significant decrease in the risk was detected for the highest quartile of intake compared with the lowest for fish fat and long-chain n-3 fatty acids; the RR were 0.56 (95% CI 0.33-0.94) and 0.50 (0.30-0.85), respectively. A decreasing trend in risk was also suggested with an increasing intake of saturated fatty acids (trend P = 0.066). Among postmenopausal women at baseline, the highest quartile of vegetable fat intake was associated with a 2.08-fold increase in risk (95% CI 1.05-4.13). This prospective study did not support any increase in the risk of breast cancer associated with total or saturated fat intake, but it suggested the protective effects of the long-chain n-3 fatty acids that are abundant in fish.

AB - To examine the possible association of dietary fat and fatty acids with breast cancer risk in a population with a low total fat intake and a high consumption of fish, we analyzed data from the Japan Collaborative Cohort (JACC) Study. From 1988 to 1990, 26 291 women aged 40-79 years completed a questionnaire on dietary and other factors. Intakes of fat or fatty acids were estimated by using a food frequency questionnaire. Rate ratios (RR) were computed by fitting proportional hazards models. During the mean follow-up of 7.6 years, 129 breast cancer cases were documented. We found no clear association of total fat intake with breast cancer risk; the multivariate-adjusted RR across quartiles were 1.00, 1.29, 0.95, and 0.80 (95% confidence interval [CI] 0.46-1.38). A significant decrease in the risk was detected for the highest quartile of intake compared with the lowest for fish fat and long-chain n-3 fatty acids; the RR were 0.56 (95% CI 0.33-0.94) and 0.50 (0.30-0.85), respectively. A decreasing trend in risk was also suggested with an increasing intake of saturated fatty acids (trend P = 0.066). Among postmenopausal women at baseline, the highest quartile of vegetable fat intake was associated with a 2.08-fold increase in risk (95% CI 1.05-4.13). This prospective study did not support any increase in the risk of breast cancer associated with total or saturated fat intake, but it suggested the protective effects of the long-chain n-3 fatty acids that are abundant in fish.

UR - http://www.scopus.com/inward/record.url?scp=27144438985&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27144438985&partnerID=8YFLogxK

U2 - 10.1111/j.1349-7006.2005.00084.x

DO - 10.1111/j.1349-7006.2005.00084.x

M3 - Article

VL - 96

SP - 590

EP - 599

JO - Cancer Science

JF - Cancer Science

SN - 1347-9032

IS - 9

ER -