Dietary linoleic acid suppresses gene expression of rat liver α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) and increases quinolinic acid in serum

Yukari Egashira, Makiko Sato, Atsushi Tanabe, Kuniaki Saito, Suwako Fujigaki, Hiroo Sanada

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Hepatic ACMSD [EC4.1.1.45] plays a key role in regulating NAD biosynthesis from tryptophan. We previously reported that ingestion of polyunsaturated fatty acids by rats leads to a decrease in their hepatic ACMSD activity. We purified ACMSD and cloned cDNA encoding rat ACMSD. Therefore, in this study, we examined whether dietary linoleic acid altered ACMSD gene expression and its protein level. Moreover we measured the tryptophan catabolite quinolinic acid level in rats. In the rats fed with linoleic acid, ACMSD mRNA and its protein levels in the liver were strongly suppressed and serum quinolinic acid was significantly increased as compared with the rats fed on a fat-free diet. These results suggest that the transcription level of ACMSD is modulated by linoleic acids or their metabolites and probably there is an inverse relationship between ACMSD activity and the production of quinolinic acid converted from tryptophan.

Original languageEnglish
Pages (from-to)671-674
Number of pages4
JournalAdvances in Experimental Medicine and Biology
Volume527
Publication statusPublished - 01-12-2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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