Dietary magnesium intake and risk of incident coronary heart disease in men: A prospective cohort study

the JPHC Study Group

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background & aims: The associations between dietary magnesium intake and stroke and coronary heart disease (CHD) incidences are inconsistent and not established in Asian. We aimed to determine the association between dietary magnesium intake and the risk of stroke and CHD in a Japanese population. Subjects/Methods: We studied 85,293 Japanese subjects by questionnaire at baseline (age 45–74 years, without cardiovascular disease or cancer in 1995 and 1998 for Cohorts I and II, respectively). The participants were followed until the end of 2009 and 2010 in Cohorts I and II, respectively. Dietary magnesium intake was estimated from a self-administered 138-item food-frequency questionnaire. Results: After 1,305,738 person-years of follow-up, 4110 strokes and 1283 cases of CHD were documented. The multivariable-adjusted hazard ratios (HRs, 95% confidence intervals, 95%CIs) of CHD for the fourth and fifth quintiles of dietary magnesium intake were 0.70 (0.50–0.99) and 0.66 (0.44–0.97) in men (P for trend = 0.036), respectively, and third quintile of dietary magnesium intake was 0.61 (0.39–0.96) in women (P for trend = 0.241), compared with the lowest quintile in men and women. We observed no decreased risks of incident stroke in men or women with higher dietary magnesium intakes. Conclusions: Higher dietary magnesium intake was associated with a reduced risk of CHD in Japanese men.

Original languageEnglish
Pages (from-to)1602-1608
Number of pages7
JournalClinical Nutrition
Volume37
Issue number5
DOIs
Publication statusPublished - 01-10-2018

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Magnesium
Coronary Disease
Cohort Studies
Prospective Studies
Stroke
Cardiovascular Diseases
Confidence Intervals
Food
Incidence
Population
Neoplasms

All Science Journal Classification (ASJC) codes

  • Nutrition and Dietetics
  • Critical Care and Intensive Care Medicine

Cite this

@article{56861010cd294212a1e86c2dae6e4993,
title = "Dietary magnesium intake and risk of incident coronary heart disease in men: A prospective cohort study",
abstract = "Background & aims: The associations between dietary magnesium intake and stroke and coronary heart disease (CHD) incidences are inconsistent and not established in Asian. We aimed to determine the association between dietary magnesium intake and the risk of stroke and CHD in a Japanese population. Subjects/Methods: We studied 85,293 Japanese subjects by questionnaire at baseline (age 45–74 years, without cardiovascular disease or cancer in 1995 and 1998 for Cohorts I and II, respectively). The participants were followed until the end of 2009 and 2010 in Cohorts I and II, respectively. Dietary magnesium intake was estimated from a self-administered 138-item food-frequency questionnaire. Results: After 1,305,738 person-years of follow-up, 4110 strokes and 1283 cases of CHD were documented. The multivariable-adjusted hazard ratios (HRs, 95{\%} confidence intervals, 95{\%}CIs) of CHD for the fourth and fifth quintiles of dietary magnesium intake were 0.70 (0.50–0.99) and 0.66 (0.44–0.97) in men (P for trend = 0.036), respectively, and third quintile of dietary magnesium intake was 0.61 (0.39–0.96) in women (P for trend = 0.241), compared with the lowest quintile in men and women. We observed no decreased risks of incident stroke in men or women with higher dietary magnesium intakes. Conclusions: Higher dietary magnesium intake was associated with a reduced risk of CHD in Japanese men.",
author = "{the JPHC Study Group} and Yoshihiro Kokubo and Isao Saito and Hiroyasu Iso and Kazumasa Yamagishi and Hiroshi Yatsuya and Junko Ishihara and Koutatsu Maruyama and Manami Inoue and Norie Sawada and Shoichiro Tsugane and S. Tsugane and N. Sawada and M. Iwasaki and S. Sasazuki and T. Yamaji and T. Shimazu and T. Hanaoka and J. Ogata and S. Baba and T. Mannami and A. Okayama and Y. Kokubo and K. Miyakawa and F. Saito and A. Koizumi and Y. Sano and I. Hashimoto and T. Ikuta and Y. Tanaba and H. Sato and Y. Roppongi and T. Takashima and H. Suzuki and Y. Miyajima and N. Suzuki and S. Nagasawa and Y. Furusugi and N. Nagai and Y. Ito and S. Komatsu and T. Minamizono and H. Sanada and Y. Hatayama and F. Kobayashi and H. Uchino and Y. Shirai and T. Kondo and R. Sasaki and Y. Watanabe and Y. Miyagawa",
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Dietary magnesium intake and risk of incident coronary heart disease in men : A prospective cohort study. / the JPHC Study Group.

In: Clinical Nutrition, Vol. 37, No. 5, 01.10.2018, p. 1602-1608.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Dietary magnesium intake and risk of incident coronary heart disease in men

T2 - A prospective cohort study

AU - the JPHC Study Group

AU - Kokubo, Yoshihiro

AU - Saito, Isao

AU - Iso, Hiroyasu

AU - Yamagishi, Kazumasa

AU - Yatsuya, Hiroshi

AU - Ishihara, Junko

AU - Maruyama, Koutatsu

AU - Inoue, Manami

AU - Sawada, Norie

AU - Tsugane, Shoichiro

AU - Tsugane, S.

AU - Sawada, N.

AU - Iwasaki, M.

AU - Sasazuki, S.

AU - Yamaji, T.

AU - Shimazu, T.

AU - Hanaoka, T.

AU - Ogata, J.

AU - Baba, S.

AU - Mannami, T.

AU - Okayama, A.

AU - Kokubo, Y.

AU - Miyakawa, K.

AU - Saito, F.

AU - Koizumi, A.

AU - Sano, Y.

AU - Hashimoto, I.

AU - Ikuta, T.

AU - Tanaba, Y.

AU - Sato, H.

AU - Roppongi, Y.

AU - Takashima, T.

AU - Suzuki, H.

AU - Miyajima, Y.

AU - Suzuki, N.

AU - Nagasawa, S.

AU - Furusugi, Y.

AU - Nagai, N.

AU - Ito, Y.

AU - Komatsu, S.

AU - Minamizono, T.

AU - Sanada, H.

AU - Hatayama, Y.

AU - Kobayashi, F.

AU - Uchino, H.

AU - Shirai, Y.

AU - Kondo, T.

AU - Sasaki, R.

AU - Watanabe, Y.

AU - Miyagawa, Y.

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Background & aims: The associations between dietary magnesium intake and stroke and coronary heart disease (CHD) incidences are inconsistent and not established in Asian. We aimed to determine the association between dietary magnesium intake and the risk of stroke and CHD in a Japanese population. Subjects/Methods: We studied 85,293 Japanese subjects by questionnaire at baseline (age 45–74 years, without cardiovascular disease or cancer in 1995 and 1998 for Cohorts I and II, respectively). The participants were followed until the end of 2009 and 2010 in Cohorts I and II, respectively. Dietary magnesium intake was estimated from a self-administered 138-item food-frequency questionnaire. Results: After 1,305,738 person-years of follow-up, 4110 strokes and 1283 cases of CHD were documented. The multivariable-adjusted hazard ratios (HRs, 95% confidence intervals, 95%CIs) of CHD for the fourth and fifth quintiles of dietary magnesium intake were 0.70 (0.50–0.99) and 0.66 (0.44–0.97) in men (P for trend = 0.036), respectively, and third quintile of dietary magnesium intake was 0.61 (0.39–0.96) in women (P for trend = 0.241), compared with the lowest quintile in men and women. We observed no decreased risks of incident stroke in men or women with higher dietary magnesium intakes. Conclusions: Higher dietary magnesium intake was associated with a reduced risk of CHD in Japanese men.

AB - Background & aims: The associations between dietary magnesium intake and stroke and coronary heart disease (CHD) incidences are inconsistent and not established in Asian. We aimed to determine the association between dietary magnesium intake and the risk of stroke and CHD in a Japanese population. Subjects/Methods: We studied 85,293 Japanese subjects by questionnaire at baseline (age 45–74 years, without cardiovascular disease or cancer in 1995 and 1998 for Cohorts I and II, respectively). The participants were followed until the end of 2009 and 2010 in Cohorts I and II, respectively. Dietary magnesium intake was estimated from a self-administered 138-item food-frequency questionnaire. Results: After 1,305,738 person-years of follow-up, 4110 strokes and 1283 cases of CHD were documented. The multivariable-adjusted hazard ratios (HRs, 95% confidence intervals, 95%CIs) of CHD for the fourth and fifth quintiles of dietary magnesium intake were 0.70 (0.50–0.99) and 0.66 (0.44–0.97) in men (P for trend = 0.036), respectively, and third quintile of dietary magnesium intake was 0.61 (0.39–0.96) in women (P for trend = 0.241), compared with the lowest quintile in men and women. We observed no decreased risks of incident stroke in men or women with higher dietary magnesium intakes. Conclusions: Higher dietary magnesium intake was associated with a reduced risk of CHD in Japanese men.

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U2 - 10.1016/j.clnu.2017.08.006

DO - 10.1016/j.clnu.2017.08.006

M3 - Article

AN - SCOPUS:85028301602

VL - 37

SP - 1602

EP - 1608

JO - Clinical Nutrition

JF - Clinical Nutrition

SN - 0261-5614

IS - 5

ER -