TY - JOUR
T1 - Dietary magnesium intake and risk of incident coronary heart disease in men
T2 - A prospective cohort study
AU - the JPHC Study Group
AU - Kokubo, Yoshihiro
AU - Saito, Isao
AU - Iso, Hiroyasu
AU - Yamagishi, Kazumasa
AU - Yatsuya, Hiroshi
AU - Ishihara, Junko
AU - Maruyama, Koutatsu
AU - Inoue, Manami
AU - Sawada, Norie
AU - Tsugane, Shoichiro
AU - Sawada, N.
AU - Iwasaki, M.
AU - Sasazuki, S.
AU - Yamaji, T.
AU - Shimazu, T.
AU - Hanaoka, T.
AU - Ogata, J.
AU - Baba, S.
AU - Mannami, T.
AU - Okayama, A.
AU - Miyakawa, K.
AU - Saito, F.
AU - Koizumi, A.
AU - Sano, Y.
AU - Hashimoto, I.
AU - Ikuta, T.
AU - Tanaba, Y.
AU - Sato, H.
AU - Roppongi, Y.
AU - Takashima, T.
AU - Suzuki, H.
AU - Miyajima, Y.
AU - Suzuki, N.
AU - Nagasawa, S.
AU - Furusugi, Y.
AU - Nagai, N.
AU - Ito, Y.
AU - Komatsu, S.
AU - Minamizono, T.
AU - Sanada, H.
AU - Hatayama, Y.
AU - Kobayashi, F.
AU - Uchino, H.
AU - Shirai, Y.
AU - Kondo, T.
AU - Sasaki, R.
AU - Watanabe, Y.
AU - Miyagawa, Y.
AU - Kobayashi, Y.
AU - Machida, M.
N1 - Publisher Copyright:
© 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism
PY - 2018/10
Y1 - 2018/10
N2 - Background & aims: The associations between dietary magnesium intake and stroke and coronary heart disease (CHD) incidences are inconsistent and not established in Asian. We aimed to determine the association between dietary magnesium intake and the risk of stroke and CHD in a Japanese population. Subjects/Methods: We studied 85,293 Japanese subjects by questionnaire at baseline (age 45–74 years, without cardiovascular disease or cancer in 1995 and 1998 for Cohorts I and II, respectively). The participants were followed until the end of 2009 and 2010 in Cohorts I and II, respectively. Dietary magnesium intake was estimated from a self-administered 138-item food-frequency questionnaire. Results: After 1,305,738 person-years of follow-up, 4110 strokes and 1283 cases of CHD were documented. The multivariable-adjusted hazard ratios (HRs, 95% confidence intervals, 95%CIs) of CHD for the fourth and fifth quintiles of dietary magnesium intake were 0.70 (0.50–0.99) and 0.66 (0.44–0.97) in men (P for trend = 0.036), respectively, and third quintile of dietary magnesium intake was 0.61 (0.39–0.96) in women (P for trend = 0.241), compared with the lowest quintile in men and women. We observed no decreased risks of incident stroke in men or women with higher dietary magnesium intakes. Conclusions: Higher dietary magnesium intake was associated with a reduced risk of CHD in Japanese men.
AB - Background & aims: The associations between dietary magnesium intake and stroke and coronary heart disease (CHD) incidences are inconsistent and not established in Asian. We aimed to determine the association between dietary magnesium intake and the risk of stroke and CHD in a Japanese population. Subjects/Methods: We studied 85,293 Japanese subjects by questionnaire at baseline (age 45–74 years, without cardiovascular disease or cancer in 1995 and 1998 for Cohorts I and II, respectively). The participants were followed until the end of 2009 and 2010 in Cohorts I and II, respectively. Dietary magnesium intake was estimated from a self-administered 138-item food-frequency questionnaire. Results: After 1,305,738 person-years of follow-up, 4110 strokes and 1283 cases of CHD were documented. The multivariable-adjusted hazard ratios (HRs, 95% confidence intervals, 95%CIs) of CHD for the fourth and fifth quintiles of dietary magnesium intake were 0.70 (0.50–0.99) and 0.66 (0.44–0.97) in men (P for trend = 0.036), respectively, and third quintile of dietary magnesium intake was 0.61 (0.39–0.96) in women (P for trend = 0.241), compared with the lowest quintile in men and women. We observed no decreased risks of incident stroke in men or women with higher dietary magnesium intakes. Conclusions: Higher dietary magnesium intake was associated with a reduced risk of CHD in Japanese men.
KW - Coronary heart disease
KW - Dietary magnesium
KW - Population study
KW - Prospective study
KW - Stroke
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UR - http://www.scopus.com/inward/citedby.url?scp=85028301602&partnerID=8YFLogxK
U2 - 10.1016/j.clnu.2017.08.006
DO - 10.1016/j.clnu.2017.08.006
M3 - Article
C2 - 28843443
AN - SCOPUS:85028301602
SN - 0261-5614
VL - 37
SP - 1602
EP - 1608
JO - Clinical Nutrition
JF - Clinical Nutrition
IS - 5
ER -
