TY - JOUR
T1 - Dietary patterns and colorectal cancer risk in Japan
T2 - The Ohsaki Cohort Study
AU - Kumagai, Yumi
AU - Chou, Wan Ting
AU - Tomata, Yasutake
AU - Sugawara, Yumi
AU - Kakizaki, Masako
AU - Nishino, Yoshikazu
AU - Tsuji, Ichiro
N1 - Funding Information:
Acknowledgments This study was supported in part by the National Cancer Center Research and Development Fund (24-A-3) and the Third Term Comprehensive Ten-Year Strategy for Cancer Control, Ministry of Health, Labour and Welfare, Japan (H23-Jun-kankitou (Seisyu)-Ippan-005).
PY - 2014/6
Y1 - 2014/6
N2 - Purpose: To evaluate dietary patterns in relation to colorectal cancer risk in Japanese. Methods: We prospectively assessed the association between dietary patterns among the Japanese and the risk of colorectal cancer. Dietary information was collected from 44,097 Japanese men and women aged 40-79 years without a history of cancer at the baseline in 1994. Results: During 11 years of follow-up, we documented 854 cases of colorectal cancer, which included 554 cases of colon cancer and 323 cases of rectal cancer. Factor analysis (principal component analysis) based on a validated food frequency questionnaire identified three dietary patterns: (1) a Japanese dietary pattern, (2) an "animal food" dietary pattern, and (3) a high-dairy, high-fruit-and-vegetable, low-alcohol (DFA) dietary pattern. After adjustment for potential confounders, the DFA pattern was inversely associated with the risk of colorectal cancer (hazard ratio of the highest quartile vs the lowest, 0.76; 95 % confidence interval 0.60-0.97; p for trend = 0.02). When colon and rectal cancers were separated, the inverse association between the DFA pattern and cancer risk was observed for rectal cancer (p for trend = 0.003), but not for colon cancer (p for trend = 0.43). No apparent association was observed for either the Japanese dietary pattern or the "animal food" dietary pattern. Conclusions: The DFA dietary pattern was found to be inversely associated with the risk of colorectal cancer. This association was observed for rectal cancer, but not for colon cancer.
AB - Purpose: To evaluate dietary patterns in relation to colorectal cancer risk in Japanese. Methods: We prospectively assessed the association between dietary patterns among the Japanese and the risk of colorectal cancer. Dietary information was collected from 44,097 Japanese men and women aged 40-79 years without a history of cancer at the baseline in 1994. Results: During 11 years of follow-up, we documented 854 cases of colorectal cancer, which included 554 cases of colon cancer and 323 cases of rectal cancer. Factor analysis (principal component analysis) based on a validated food frequency questionnaire identified three dietary patterns: (1) a Japanese dietary pattern, (2) an "animal food" dietary pattern, and (3) a high-dairy, high-fruit-and-vegetable, low-alcohol (DFA) dietary pattern. After adjustment for potential confounders, the DFA pattern was inversely associated with the risk of colorectal cancer (hazard ratio of the highest quartile vs the lowest, 0.76; 95 % confidence interval 0.60-0.97; p for trend = 0.02). When colon and rectal cancers were separated, the inverse association between the DFA pattern and cancer risk was observed for rectal cancer (p for trend = 0.003), but not for colon cancer (p for trend = 0.43). No apparent association was observed for either the Japanese dietary pattern or the "animal food" dietary pattern. Conclusions: The DFA dietary pattern was found to be inversely associated with the risk of colorectal cancer. This association was observed for rectal cancer, but not for colon cancer.
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U2 - 10.1007/s10552-014-0375-5
DO - 10.1007/s10552-014-0375-5
M3 - Article
C2 - 24682746
AN - SCOPUS:84901231940
SN - 0957-5243
VL - 25
SP - 727
EP - 736
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 6
ER -