Difference in autonomic nervous control between ventricular septal defect and atrial septal defect based on heart rate variability

Tadayoshi Hata, Seiko Mano, Masafumi Kusuki, Hideaki Matsuura, Masafumi Miyata, Toshio Yamazaki, Syunji Nagaoka

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: We hypothesized that patients with atrial (ASD) and ventricular septal defects (VSD) have similarly reduced heart rate variability (HRV) since both defects cause similar increases in pulmonary blood flow and right ventricular filling pressure. We examined the correlation between HRV and respiratory frequency (RSA) characteristics and left-to-right shunt ratio (Qp/Qs) measured by Doppler echocardiography. Methods: The study included 83 patients with diagnoses of ASD (n = 43) or VSD (n = 40). The electrocardiogram and respiratory waves were recorded during Doppler echocardiography test, and HRV was measured to calculate the low frequency (LF), high frequency (HF), total frequency (TF), and RSA components, and the LF/HF, RSA/TF, and LF/RSA ratios. Qp/Qs was calculated from Doppler echocardiography and its relationship with HRV parameters was examined by multivariate analysis. Results: There was a positive correlation between Qp/Qs and LF/RSA in the ASD group, and a negative correlation in the VSD group. In contrast, Qp/Qs correlated negatively with RSA/TF in the ASD group, and positively in the VSD group. Conclusion: Different effects of respiratory vagal activity on HRV were observed in patients with ASD versus VSD.

Original languageEnglish
JournalPACE - Pacing and Clinical Electrophysiology
Volume30
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 01-01-2007

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Atrial Heart Septal Defects
Ventricular Heart Septal Defects
Heart Rate
Doppler Echocardiography
Ventricular Pressure
Electrocardiography
Multivariate Analysis
Lung

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Hata, Tadayoshi ; Mano, Seiko ; Kusuki, Masafumi ; Matsuura, Hideaki ; Miyata, Masafumi ; Yamazaki, Toshio ; Nagaoka, Syunji. / Difference in autonomic nervous control between ventricular septal defect and atrial septal defect based on heart rate variability. In: PACE - Pacing and Clinical Electrophysiology. 2007 ; Vol. 30, No. SUPPL. 1.
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Difference in autonomic nervous control between ventricular septal defect and atrial septal defect based on heart rate variability. / Hata, Tadayoshi; Mano, Seiko; Kusuki, Masafumi; Matsuura, Hideaki; Miyata, Masafumi; Yamazaki, Toshio; Nagaoka, Syunji.

In: PACE - Pacing and Clinical Electrophysiology, Vol. 30, No. SUPPL. 1, 01.01.2007.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Difference in autonomic nervous control between ventricular septal defect and atrial septal defect based on heart rate variability

AU - Hata, Tadayoshi

AU - Mano, Seiko

AU - Kusuki, Masafumi

AU - Matsuura, Hideaki

AU - Miyata, Masafumi

AU - Yamazaki, Toshio

AU - Nagaoka, Syunji

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Background: We hypothesized that patients with atrial (ASD) and ventricular septal defects (VSD) have similarly reduced heart rate variability (HRV) since both defects cause similar increases in pulmonary blood flow and right ventricular filling pressure. We examined the correlation between HRV and respiratory frequency (RSA) characteristics and left-to-right shunt ratio (Qp/Qs) measured by Doppler echocardiography. Methods: The study included 83 patients with diagnoses of ASD (n = 43) or VSD (n = 40). The electrocardiogram and respiratory waves were recorded during Doppler echocardiography test, and HRV was measured to calculate the low frequency (LF), high frequency (HF), total frequency (TF), and RSA components, and the LF/HF, RSA/TF, and LF/RSA ratios. Qp/Qs was calculated from Doppler echocardiography and its relationship with HRV parameters was examined by multivariate analysis. Results: There was a positive correlation between Qp/Qs and LF/RSA in the ASD group, and a negative correlation in the VSD group. In contrast, Qp/Qs correlated negatively with RSA/TF in the ASD group, and positively in the VSD group. Conclusion: Different effects of respiratory vagal activity on HRV were observed in patients with ASD versus VSD.

AB - Background: We hypothesized that patients with atrial (ASD) and ventricular septal defects (VSD) have similarly reduced heart rate variability (HRV) since both defects cause similar increases in pulmonary blood flow and right ventricular filling pressure. We examined the correlation between HRV and respiratory frequency (RSA) characteristics and left-to-right shunt ratio (Qp/Qs) measured by Doppler echocardiography. Methods: The study included 83 patients with diagnoses of ASD (n = 43) or VSD (n = 40). The electrocardiogram and respiratory waves were recorded during Doppler echocardiography test, and HRV was measured to calculate the low frequency (LF), high frequency (HF), total frequency (TF), and RSA components, and the LF/HF, RSA/TF, and LF/RSA ratios. Qp/Qs was calculated from Doppler echocardiography and its relationship with HRV parameters was examined by multivariate analysis. Results: There was a positive correlation between Qp/Qs and LF/RSA in the ASD group, and a negative correlation in the VSD group. In contrast, Qp/Qs correlated negatively with RSA/TF in the ASD group, and positively in the VSD group. Conclusion: Different effects of respiratory vagal activity on HRV were observed in patients with ASD versus VSD.

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