Differences in the cerebrovascular anatomy of C57Black/6 and SV129 mice

Keiichiro Maeda, Ryuji Hata, Konstantin Alexander Hossmann

Research output: Contribution to journalArticlepeer-review

101 Citations (Scopus)

Abstract

The vascular architecture of the brain of C57Black/6 and SV129 mice was studied following microvascular injection of carbon black stained latex. The dorsal brain surface was photographed to determine the number, diameter, and position of pial anastomotic vessels between the middle and anterior cerebral arteries. The mean number and diameter of anastomoses were not significantly different, but the line of anastomoses interconnecting the half way points of anastomotic vessels was located significantly closer to the midline in C57Black/6 mice, demonstrating that the middle cerebral artery had a larger vascular supplying territory than in SV129 mice. This explains the larger infarct volume previously reported in C57Black/6 mice, and raises concerns about the use of C57Black/6 and SV129 mice as parent strains for genetically modified animals in stroke research.

Original languageEnglish
Pages (from-to)1317-1319
Number of pages3
JournalNeuroreport
Volume9
Issue number7
DOIs
Publication statusPublished - 11-05-1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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