Differences in urinary arsenic metabolites between diabetic and non-diabetic subjects in Bangladesh

Saika Nizam, Masashi Kato, Hiroshi Yatsuya, Md Khalequzzaman, Shoko Ohnuma, Hisao Naito, Tamie Nakajima

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Ingestion of inorganic arsenic (iAs) is considered to be related to the development of diabetes mellitus. In order to clarify the possible differences in the metabolism in diabetics, we measured urinary iAs metabolites in diabetic cases and non-diabetic control subjects in Faridpur, an arsenic-contaminated area in Bangladesh. Physician-diagnosed type 2 diabetic cases (140 persons) and non-diabetic controls (180 persons) were recruited. Drinking water and spot urine samples were collected. Mean concentrations of total arsenic in drinking water did not differ between cases (85.1 μg/L) and controls (85.8 μg/L). The percentage of urinary iAs (iAs%) was significantly lower in cases (8.6%) than in controls (10.4%), while that of dimethylarsinic acid (DMA%) was higher in cases (82.6%) than in controls (79.9%). This may have been due to the higher secondary methylation index (SMI) in the former (11.6) rather than the latter (10.0). Adjusting for matching factors (sex and unions), and the additional other covariates (age and water arsenic) significantly attenuated the differences in iAs%, SMI, and DMA%, respectively, though the difference in monomethylarsonic acid% was newly significant in the latter adjustment. Our study did not suggest any significant differences in urinary arsenic metabolites between diabetic and non-diabetic subjects.

Original languageEnglish
Pages (from-to)1006-1019
Number of pages14
JournalInternational Journal of Environmental Research and Public Health
Volume10
Issue number3
DOIs
Publication statusPublished - 01-03-2013

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Bangladesh
Arsenic
Drinking Water
Methylation
Cacodylic Acid
Sex Factors
Diabetes Mellitus
Eating
Urine
Physicians
Water

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

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title = "Differences in urinary arsenic metabolites between diabetic and non-diabetic subjects in Bangladesh",
abstract = "Ingestion of inorganic arsenic (iAs) is considered to be related to the development of diabetes mellitus. In order to clarify the possible differences in the metabolism in diabetics, we measured urinary iAs metabolites in diabetic cases and non-diabetic control subjects in Faridpur, an arsenic-contaminated area in Bangladesh. Physician-diagnosed type 2 diabetic cases (140 persons) and non-diabetic controls (180 persons) were recruited. Drinking water and spot urine samples were collected. Mean concentrations of total arsenic in drinking water did not differ between cases (85.1 μg/L) and controls (85.8 μg/L). The percentage of urinary iAs (iAs{\%}) was significantly lower in cases (8.6{\%}) than in controls (10.4{\%}), while that of dimethylarsinic acid (DMA{\%}) was higher in cases (82.6{\%}) than in controls (79.9{\%}). This may have been due to the higher secondary methylation index (SMI) in the former (11.6) rather than the latter (10.0). Adjusting for matching factors (sex and unions), and the additional other covariates (age and water arsenic) significantly attenuated the differences in iAs{\%}, SMI, and DMA{\%}, respectively, though the difference in monomethylarsonic acid{\%} was newly significant in the latter adjustment. Our study did not suggest any significant differences in urinary arsenic metabolites between diabetic and non-diabetic subjects.",
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Differences in urinary arsenic metabolites between diabetic and non-diabetic subjects in Bangladesh. / Nizam, Saika; Kato, Masashi; Yatsuya, Hiroshi; Khalequzzaman, Md; Ohnuma, Shoko; Naito, Hisao; Nakajima, Tamie.

In: International Journal of Environmental Research and Public Health, Vol. 10, No. 3, 01.03.2013, p. 1006-1019.

Research output: Contribution to journalArticle

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T1 - Differences in urinary arsenic metabolites between diabetic and non-diabetic subjects in Bangladesh

AU - Nizam, Saika

AU - Kato, Masashi

AU - Yatsuya, Hiroshi

AU - Khalequzzaman, Md

AU - Ohnuma, Shoko

AU - Naito, Hisao

AU - Nakajima, Tamie

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