Differences of alteration in opioid systems induced by conditioned suppression and electric footshock in mice

Tsutomu Kameyama, Toshitaka Nabeshima, Kiyofumi Yamada

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The motility, pain-threshold and opioid receptor activities of the synaptic membrane in mice showing conditioned suppression of motility were compared with those in mice given only electric footshock. Electric footshock caused analgesia and a decrease in motility, both of which were partially reversed by administration of high doses of naloxone. In contrast, mice exhibited a marked suppression of motility (conditioned suppression) but not analgesia when placed in the same environment 24 hr after the electric footshock in which the animals received the electric footshock. In the electric footshock group, the [3H]-naloxone binding capacity at low affinity site was increased. These results suggest that the increase in [3H]-naloxone binding capacity may play an important role in the behavioral changes of electric footshock group, but not conditioned suppression group.

Original languageEnglish
Pages (from-to)249-254
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume22
Issue number2
DOIs
Publication statusPublished - 01-01-1985
Externally publishedYes

Fingerprint

Naloxone
Opioid Analgesics
Analgesia
Synaptic Membranes
Nociceptors
Pain Threshold
Opioid Receptors
Animals
Membranes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

@article{e50ff894a1db48f691c52b429917b641,
title = "Differences of alteration in opioid systems induced by conditioned suppression and electric footshock in mice",
abstract = "The motility, pain-threshold and opioid receptor activities of the synaptic membrane in mice showing conditioned suppression of motility were compared with those in mice given only electric footshock. Electric footshock caused analgesia and a decrease in motility, both of which were partially reversed by administration of high doses of naloxone. In contrast, mice exhibited a marked suppression of motility (conditioned suppression) but not analgesia when placed in the same environment 24 hr after the electric footshock in which the animals received the electric footshock. In the electric footshock group, the [3H]-naloxone binding capacity at low affinity site was increased. These results suggest that the increase in [3H]-naloxone binding capacity may play an important role in the behavioral changes of electric footshock group, but not conditioned suppression group.",
author = "Tsutomu Kameyama and Toshitaka Nabeshima and Kiyofumi Yamada",
year = "1985",
month = "1",
day = "1",
doi = "10.1016/0091-3057(85)90386-7",
language = "English",
volume = "22",
pages = "249--254",
journal = "Pharmacology Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "2",

}

Differences of alteration in opioid systems induced by conditioned suppression and electric footshock in mice. / Kameyama, Tsutomu; Nabeshima, Toshitaka; Yamada, Kiyofumi.

In: Pharmacology, Biochemistry and Behavior, Vol. 22, No. 2, 01.01.1985, p. 249-254.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Differences of alteration in opioid systems induced by conditioned suppression and electric footshock in mice

AU - Kameyama, Tsutomu

AU - Nabeshima, Toshitaka

AU - Yamada, Kiyofumi

PY - 1985/1/1

Y1 - 1985/1/1

N2 - The motility, pain-threshold and opioid receptor activities of the synaptic membrane in mice showing conditioned suppression of motility were compared with those in mice given only electric footshock. Electric footshock caused analgesia and a decrease in motility, both of which were partially reversed by administration of high doses of naloxone. In contrast, mice exhibited a marked suppression of motility (conditioned suppression) but not analgesia when placed in the same environment 24 hr after the electric footshock in which the animals received the electric footshock. In the electric footshock group, the [3H]-naloxone binding capacity at low affinity site was increased. These results suggest that the increase in [3H]-naloxone binding capacity may play an important role in the behavioral changes of electric footshock group, but not conditioned suppression group.

AB - The motility, pain-threshold and opioid receptor activities of the synaptic membrane in mice showing conditioned suppression of motility were compared with those in mice given only electric footshock. Electric footshock caused analgesia and a decrease in motility, both of which were partially reversed by administration of high doses of naloxone. In contrast, mice exhibited a marked suppression of motility (conditioned suppression) but not analgesia when placed in the same environment 24 hr after the electric footshock in which the animals received the electric footshock. In the electric footshock group, the [3H]-naloxone binding capacity at low affinity site was increased. These results suggest that the increase in [3H]-naloxone binding capacity may play an important role in the behavioral changes of electric footshock group, but not conditioned suppression group.

UR - http://www.scopus.com/inward/record.url?scp=0022000543&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022000543&partnerID=8YFLogxK

U2 - 10.1016/0091-3057(85)90386-7

DO - 10.1016/0091-3057(85)90386-7

M3 - Article

C2 - 2984703

AN - SCOPUS:0022000543

VL - 22

SP - 249

EP - 254

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

SN - 0091-3057

IS - 2

ER -