Different changes by acute electric footshock of opioid agonist and antagonist receptors in rat brain

Tsutomu Kameyama, Toshitaka Nabeshima, Kiyoshi Matsuno, Masahiko Suzuki

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Electric shock (ES) produces an opiate-like analgesia and catalepsy in rats, which may be mediated by endogenous opioid systems. The present study was designed to investigate the alterations of endogenous opioid receptors by an intermittent ES application. In a case of opiate agonists, [3H]dihydromorphine and [3H]d-Ala-Met-enkephalinamide, the application of ES produced a decrease of [3H]ligands' binding capacity. On the contrary, the binding capacity of the opiate antagonist [3H]naloxone was increased by the ES application. These results suggest that endogenous putative opioid agonist- and antagonist-type receptors are differently regulated in vivo.

Original languageEnglish
Pages (from-to)307-312
Number of pages6
JournalNeuroscience Letters
Issue number3
Publication statusPublished - 31-08-1984


All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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