TY - JOUR
T1 - Different changes by acute electric footshock of opioid agonist and antagonist receptors in rat brain
AU - Kameyama, Tsutomu
AU - Nabeshima, Toshitaka
AU - Matsuno, Kiyoshi
AU - Suzuki, Masahiko
PY - 1984/8/31
Y1 - 1984/8/31
N2 - Electric shock (ES) produces an opiate-like analgesia and catalepsy in rats, which may be mediated by endogenous opioid systems. The present study was designed to investigate the alterations of endogenous opioid receptors by an intermittent ES application. In a case of opiate agonists, [3H]dihydromorphine and [3H]d-Ala-Met-enkephalinamide, the application of ES produced a decrease of [3H]ligands' binding capacity. On the contrary, the binding capacity of the opiate antagonist [3H]naloxone was increased by the ES application. These results suggest that endogenous putative opioid agonist- and antagonist-type receptors are differently regulated in vivo.
AB - Electric shock (ES) produces an opiate-like analgesia and catalepsy in rats, which may be mediated by endogenous opioid systems. The present study was designed to investigate the alterations of endogenous opioid receptors by an intermittent ES application. In a case of opiate agonists, [3H]dihydromorphine and [3H]d-Ala-Met-enkephalinamide, the application of ES produced a decrease of [3H]ligands' binding capacity. On the contrary, the binding capacity of the opiate antagonist [3H]naloxone was increased by the ES application. These results suggest that endogenous putative opioid agonist- and antagonist-type receptors are differently regulated in vivo.
UR - https://www.scopus.com/pages/publications/0021226207
UR - https://www.scopus.com/inward/citedby.url?scp=0021226207&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(84)90307-0
DO - 10.1016/0304-3940(84)90307-0
M3 - Article
C2 - 6093006
AN - SCOPUS:0021226207
SN - 0304-3940
VL - 49
SP - 307
EP - 312
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 3
ER -