Differential diagnosis of pancreatic cancer and focal pancreatitis by using EUS-guided FNA

Kuniyuki Takahashi, Kenji Yamao, Kenji Okubo, Akira Sawaki, Nobumasa Mizuno, Reiko Ashida, Takashi Koshikawa, Yuji Ueyama, Kunio Kasugai, Satoshi Hase, Shinichi Kakumu

Research output: Contribution to journalArticlepeer-review

124 Citations (Scopus)

Abstract

Despite advances in diagnostic imaging techniques, the differentiation between pancreatic cancer and focal pancreatitis remains difficult. This study evaluated the effectiveness of EUS-guided FNA in the differential diagnosis between pancreatic cancer and focal pancreatitis, with particular reference to detection of the K-ras point mutation. The study included 62 consecutive patients with pancreatic ductal cancer and 15 patients with focal pancreatitis demonstrated as a pancreatic mass lesion by EUS. Sensitivity, specificity, overall accuracy, positive predictive value, and negative predictive value of cytopathologic diagnosis were 82%, 100%, 86%, 100%, and 58%, respectively. Sensitivity, specificity, overall accuracy, positive predictive value, and negative predictive value of histopathologic diagnosis were 44%, 100%, 55%, 100%, and 32%, respectively. The K-ras point mutation was found in 74% of pancreatic cancers and 0% of focal pancreatitis lesions. No complication of EUS-guided FNA was observed. EUS-guided FNA is useful for the differential diagnosis of pancreatic mass lesions caused by pancreatic cancer and focal pancreatitis. Analysis for the K-ras point mutation in specimens obtained by EUS-guided FNA may enhance diagnostic accuracy in indeterminate cases.

Original languageEnglish
Pages (from-to)76-79
Number of pages4
JournalGastrointestinal endoscopy
Volume61
Issue number1
DOIs
Publication statusPublished - 01-2005

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

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