Differential effects of aging, drinking and exercise on serum cholesterol levels dependent on the PPARA-V227A polymorphism

Hisao Naito, Michihiro Kamijima, Osamu Yamanoshita, Ai Nakahara, Takahiko Katoh, Naoki Tanaka, Toshifumi Aoyama, Frank J. Gonzalez, Tamie Nakajima

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Peroxisome proliferator-activated receptor α (PPARα) plays a pivotal role in lipid metabolism. Our previous study reported that PPARA-V227A was a major polymorphism in Japanese, which was associated with markedly lower serum total cholesterol (TC) levels, which were significantly affected by alcohol drinking compared to subjects with the wild-type ( PPARA-WT) allele. However, serum lipids are also associated with aging and exercise frequency. The objective of the present study was to evaluate the relationship between PPARA-V227A and these factors. Genetic analysis of the polymorphism was performed in 1058 Japanese men and 281 women, and the relationship with aging, drinking and exercise on serum lipids was analyzed in 989 men and 245 women after exclusion criteria had been applied. In men, drinking increased high-density lipoprotein cholesterol (HDL-C) levels in both PPARA-WT and A227 carriers, but to a significantly higher degree in the latter. In women, TC and low-density lipoprotein cholesterol (LDL-C) levels in the A227 carriers drinking at least once a week were significantly higher than in PPARA-WT carriers. TC and LDL-C levels in males with PPARA-WT increased with aging regardless of drinking habit, while LDL-C levels in the A227 drinking carriers were significantly lower in 45-yr-old or older subjects than in 35- to 45-yr-olds. In addition, no effect of exercising was observed in the A227 carriers, while increase in the HDL-C of the PPARA-WT carriers was exercise frequency dependent. These results suggest that the influence of drinking, aging or exercise on TC, LDL-C and HDLC levels in the A227 carriers may be different from those in the PPARA-WT subjects.

Original languageEnglish
Pages (from-to)353-362
Number of pages10
JournalJournal of Occupational Health
Volume49
Issue number5
DOIs
Publication statusPublished - 01-09-2007

Fingerprint

Drinking
Cholesterol
Exercise
LDL Cholesterol
Serum
HDL Cholesterol
Lipids
Peroxisome Proliferator-Activated Receptors
Lipid Metabolism
Alcohol Drinking
Habits
Alleles

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

Naito, Hisao ; Kamijima, Michihiro ; Yamanoshita, Osamu ; Nakahara, Ai ; Katoh, Takahiko ; Tanaka, Naoki ; Aoyama, Toshifumi ; Gonzalez, Frank J. ; Nakajima, Tamie. / Differential effects of aging, drinking and exercise on serum cholesterol levels dependent on the PPARA-V227A polymorphism. In: Journal of Occupational Health. 2007 ; Vol. 49, No. 5. pp. 353-362.
@article{0399afb02fca46b8854c4585531611fc,
title = "Differential effects of aging, drinking and exercise on serum cholesterol levels dependent on the PPARA-V227A polymorphism",
abstract = "Peroxisome proliferator-activated receptor α (PPARα) plays a pivotal role in lipid metabolism. Our previous study reported that PPARA-V227A was a major polymorphism in Japanese, which was associated with markedly lower serum total cholesterol (TC) levels, which were significantly affected by alcohol drinking compared to subjects with the wild-type ( PPARA-WT) allele. However, serum lipids are also associated with aging and exercise frequency. The objective of the present study was to evaluate the relationship between PPARA-V227A and these factors. Genetic analysis of the polymorphism was performed in 1058 Japanese men and 281 women, and the relationship with aging, drinking and exercise on serum lipids was analyzed in 989 men and 245 women after exclusion criteria had been applied. In men, drinking increased high-density lipoprotein cholesterol (HDL-C) levels in both PPARA-WT and A227 carriers, but to a significantly higher degree in the latter. In women, TC and low-density lipoprotein cholesterol (LDL-C) levels in the A227 carriers drinking at least once a week were significantly higher than in PPARA-WT carriers. TC and LDL-C levels in males with PPARA-WT increased with aging regardless of drinking habit, while LDL-C levels in the A227 drinking carriers were significantly lower in 45-yr-old or older subjects than in 35- to 45-yr-olds. In addition, no effect of exercising was observed in the A227 carriers, while increase in the HDL-C of the PPARA-WT carriers was exercise frequency dependent. These results suggest that the influence of drinking, aging or exercise on TC, LDL-C and HDLC levels in the A227 carriers may be different from those in the PPARA-WT subjects.",
author = "Hisao Naito and Michihiro Kamijima and Osamu Yamanoshita and Ai Nakahara and Takahiko Katoh and Naoki Tanaka and Toshifumi Aoyama and Gonzalez, {Frank J.} and Tamie Nakajima",
year = "2007",
month = "9",
day = "1",
doi = "10.1539/joh.49.353",
language = "English",
volume = "49",
pages = "353--362",
journal = "Sangyo eiseigaku zasshi = Journal of occupational health",
issn = "1341-9145",
publisher = "Japan Society for Occupational Health",
number = "5",

}

Naito, H, Kamijima, M, Yamanoshita, O, Nakahara, A, Katoh, T, Tanaka, N, Aoyama, T, Gonzalez, FJ & Nakajima, T 2007, 'Differential effects of aging, drinking and exercise on serum cholesterol levels dependent on the PPARA-V227A polymorphism', Journal of Occupational Health, vol. 49, no. 5, pp. 353-362. https://doi.org/10.1539/joh.49.353

Differential effects of aging, drinking and exercise on serum cholesterol levels dependent on the PPARA-V227A polymorphism. / Naito, Hisao; Kamijima, Michihiro; Yamanoshita, Osamu; Nakahara, Ai; Katoh, Takahiko; Tanaka, Naoki; Aoyama, Toshifumi; Gonzalez, Frank J.; Nakajima, Tamie.

In: Journal of Occupational Health, Vol. 49, No. 5, 01.09.2007, p. 353-362.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Differential effects of aging, drinking and exercise on serum cholesterol levels dependent on the PPARA-V227A polymorphism

AU - Naito, Hisao

AU - Kamijima, Michihiro

AU - Yamanoshita, Osamu

AU - Nakahara, Ai

AU - Katoh, Takahiko

AU - Tanaka, Naoki

AU - Aoyama, Toshifumi

AU - Gonzalez, Frank J.

AU - Nakajima, Tamie

PY - 2007/9/1

Y1 - 2007/9/1

N2 - Peroxisome proliferator-activated receptor α (PPARα) plays a pivotal role in lipid metabolism. Our previous study reported that PPARA-V227A was a major polymorphism in Japanese, which was associated with markedly lower serum total cholesterol (TC) levels, which were significantly affected by alcohol drinking compared to subjects with the wild-type ( PPARA-WT) allele. However, serum lipids are also associated with aging and exercise frequency. The objective of the present study was to evaluate the relationship between PPARA-V227A and these factors. Genetic analysis of the polymorphism was performed in 1058 Japanese men and 281 women, and the relationship with aging, drinking and exercise on serum lipids was analyzed in 989 men and 245 women after exclusion criteria had been applied. In men, drinking increased high-density lipoprotein cholesterol (HDL-C) levels in both PPARA-WT and A227 carriers, but to a significantly higher degree in the latter. In women, TC and low-density lipoprotein cholesterol (LDL-C) levels in the A227 carriers drinking at least once a week were significantly higher than in PPARA-WT carriers. TC and LDL-C levels in males with PPARA-WT increased with aging regardless of drinking habit, while LDL-C levels in the A227 drinking carriers were significantly lower in 45-yr-old or older subjects than in 35- to 45-yr-olds. In addition, no effect of exercising was observed in the A227 carriers, while increase in the HDL-C of the PPARA-WT carriers was exercise frequency dependent. These results suggest that the influence of drinking, aging or exercise on TC, LDL-C and HDLC levels in the A227 carriers may be different from those in the PPARA-WT subjects.

AB - Peroxisome proliferator-activated receptor α (PPARα) plays a pivotal role in lipid metabolism. Our previous study reported that PPARA-V227A was a major polymorphism in Japanese, which was associated with markedly lower serum total cholesterol (TC) levels, which were significantly affected by alcohol drinking compared to subjects with the wild-type ( PPARA-WT) allele. However, serum lipids are also associated with aging and exercise frequency. The objective of the present study was to evaluate the relationship between PPARA-V227A and these factors. Genetic analysis of the polymorphism was performed in 1058 Japanese men and 281 women, and the relationship with aging, drinking and exercise on serum lipids was analyzed in 989 men and 245 women after exclusion criteria had been applied. In men, drinking increased high-density lipoprotein cholesterol (HDL-C) levels in both PPARA-WT and A227 carriers, but to a significantly higher degree in the latter. In women, TC and low-density lipoprotein cholesterol (LDL-C) levels in the A227 carriers drinking at least once a week were significantly higher than in PPARA-WT carriers. TC and LDL-C levels in males with PPARA-WT increased with aging regardless of drinking habit, while LDL-C levels in the A227 drinking carriers were significantly lower in 45-yr-old or older subjects than in 35- to 45-yr-olds. In addition, no effect of exercising was observed in the A227 carriers, while increase in the HDL-C of the PPARA-WT carriers was exercise frequency dependent. These results suggest that the influence of drinking, aging or exercise on TC, LDL-C and HDLC levels in the A227 carriers may be different from those in the PPARA-WT subjects.

UR - http://www.scopus.com/inward/record.url?scp=37549026824&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37549026824&partnerID=8YFLogxK

U2 - 10.1539/joh.49.353

DO - 10.1539/joh.49.353

M3 - Article

C2 - 17951966

AN - SCOPUS:37549026824

VL - 49

SP - 353

EP - 362

JO - Sangyo eiseigaku zasshi = Journal of occupational health

JF - Sangyo eiseigaku zasshi = Journal of occupational health

SN - 1341-9145

IS - 5

ER -